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Pituitary Tumor-Transforming 1 Proteins (PTTG1)

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. Additionally we are shipping PTTG1 Antibodies (70) and PTTG1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTTG1 9232 O95997
PTTG1 64193 P97613
PTTG1 30939 Q9CQJ7
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Top PTTG1 Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,240.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,480.50
Details
Yeast Pan troglodytes His tag   1 mg Log in to see 56 to 66 Days
$2,489.67
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,489.67
Details
Yeast Schizosaccharomyces pombe His tag   1 mg Log in to see 56 to 66 Days
$2,799.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$467.86
Details

PTTG1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

Mouse (Murine)

Top referenced PTTG1 Proteins

  1. Human PTTG1 Protein expressed in Escherichia coli (E. coli) - ABIN666649 : Chien, Pei: A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product. in The Journal of biological chemistry 2000 (PubMed)
    Show all 2 references for ABIN666649

More Proteins for Pituitary Tumor-Transforming 1 (PTTG1) Interaction Partners

Human Pituitary Tumor-Transforming 1 (PTTG1) interaction partners

  1. Pttg1 may increase BC cell growth through nuclear exclusion of p27 (show PAK2 Proteins), which highlights a novel molecular regulatory machinery in tumorigenesis of BC.

  2. Data show that overexpression of c-myc proto-oncogene (show MYC Proteins) protein (show MYC Proteins) could prevent the metabolic shift induced by pituitary tumor-transforming gene (PTTG) knockwown.

  3. Report feedback loop between PTTG1 targeting miRNAs, PTTG1 and p53 (show TP53 Proteins) that promotes pituitary tumorigenesis.

  4. knockdown of PTTG1 increased expression of integrin alpha 4 (ITGA4 (show ITGA4 Proteins)), ITGA5 (show ITGA5 Proteins), and integrin beta 1 (ITGB1 (show ITGB1 Proteins)); otherwise, RhoA (show RHOA Proteins) expression was significantly decreased

  5. Data show that pituitary tumor-transforming 1 protein (PTTG1) is over-expressed in multiple myeloma (MM) patients and is associated with poor survival.

  6. Silencing of PTTG could also inhibit tumor growth, invasion, and angiogenesis in vivo. Our data indicated that PTTG might be a potential target for glioma treatment

  7. FoxM1 (show FOXM1 Proteins) binds to PTTG1 promoter to enhance PTTG1 transcription, and FoxM1 (show FOXM1 Proteins)-PTTG1 pathway promotes colorectal cancer migration and invasion

  8. we demonstrated here the inhibitory effect of CACP (show PRG4 Proteins) on the growth of H22 cells in vitro and in vivo, which may be through, at least partly, repression of PTTG1 and then followed by the inactivation of P13/Akt (show AKT1 Proteins) and activation of p38 (show CRK Proteins) MARK signaling pathways

  9. our data suggest that Pttg1 may increase CC cell metastasis, which is negatively regulated by miR (show MLXIP Proteins)-494

  10. PTTG1 enhances HBV replication through suppression of P53 (show TP53 Proteins).

Pig (Porcine) Pituitary Tumor-Transforming 1 (PTTG1) interaction partners

  1. PTTG1 is a new candidate maternal effect gene that may participate in the processes of oocyte maturation and zygotic genome activation during embryogenesis

Mouse (Murine) Pituitary Tumor-Transforming 1 (PTTG1) interaction partners

  1. PTTG is functionally required for hepatic fibrosis progression in an animal model of chronic liver injury, and thus a potential treatment target.

  2. RasGrf1 (show RASGRF1 Proteins) is an important upstream component of signal transduction pathways regulating Pttg1 expression and controlling beta cell development and physiological responses.

  3. these results implicate Pttg1 in the regulation of homotypic spacing between specific types of retinal neurons.

  4. Pttg1/securin has roles in branching morphogenesis of the mammary gland and suppression of mammary tumorigenesis

  5. PBF (show PTTG1IP Proteins) is the first protein to interact with the critical TH transporter MCT8 (show MCT8 Proteins) and modulate its function in vivo

  6. CSN3 (show CSN3 Proteins) and CSN5 (show COPS5 Proteins) are involved in oocyte meiosis by regulating degradation of Cyclin B1 (show CCNB1 Proteins) and Securin via APC (show APC Proteins)/C.

  7. The genetically deleting Tff3 (show TFF3 Proteins) in mice altered down-regulated Pttg1 and up-regulated serpina3n (show SERPINA3N Proteins) expression, indicating a potential role of these factors during the development of presbyacusis.

  8. data reveal that up to 9 months of age, Pttg1(-/-) retinas have a healthy morphology and normal photoreceptor function

  9. Pituitary tumor transforming gene 1 (PTTG1), an oncogene (show RAB1A Proteins), was the most up-regulated transcript in KLF6 (show KLF6 Proteins)+/- liver. PTTG1 downregulation represents a novel tumor suppressor pathway of KLF6 (show KLF6 Proteins).

  10. Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes.

PTTG1 Protein Profile

Protein Summary

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.

Gene names and symbols associated with PTTG1

  • pituitary tumor-transforming 1 (PTTG1)
  • pituitary tumor-transforming 1 (Pttg1)
  • pituitary tumor-transforming gene 1 (Pttg1)
  • AW555095 protein
  • C87862 protein
  • EAP1 protein
  • HPTTG protein
  • Pttg protein
  • PTTG1 protein
  • Pttg3 protein
  • Securin protein
  • TUTR1 protein

Protein level used designations for PTTG1

pituitary tumor-transforming protein 1 , securin , pituitary tumor-transforming 1 , ESP1-associated protein 1 , pituitary tumor-transforming gene 1 protein , tumor-transforming protein 1 , Pituitary tumor transforming

GENE ID SPECIES
416158 Gallus gallus
479307 Canis lupus familiaris
510673 Bos taurus
539883 Bos taurus
696143 Macaca mulatta
9232 Homo sapiens
64193 Rattus norvegicus
397015 Sus scrofa
508043 Bos taurus
462238 Pan troglodytes
30939 Mus musculus
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