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Pituitary Tumor-Transforming 1 Interacting Protein Proteins (PTTG1IP)

The encoded protein, which directly binds to pituitary tumor-transforming gene 1 protein (PTTG1), facilitates the nuclear translocation of PTTG1 and potentiates the transcriptional activation of basic fibroblast growth factor by PTTG1. Additionally we are shipping PTTG1IP Antibodies (25) and PTTG1IP Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTTG1IP 108705 Q8R143
Rat PTTG1IP PTTG1IP 365548 Q6P767
PTTG1IP 754 P53801
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Top PTTG1IP Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,062.50
Details

PTTG1IP Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Pituitary Tumor-Transforming 1 Interacting Protein (PTTG1IP) Interaction Partners

Mouse (Murine) Pituitary Tumor-Transforming 1 Interacting Protein (PTTG1IP) interaction partners

  1. protooncogene PBF is a negative regulator of p53 (show TP53 Proteins) function in thyroid tumorigenesis, in which PBF is generally overexpressed and p53 (show TP53 Proteins) mutations are rare compared with other tumor types

Human Pituitary Tumor-Transforming 1 Interacting Protein (PTTG1IP) interaction partners

  1. these results demonstrate an emerging role for PBF in colorectal tumorigenesis through regulating p53 (show TP53 Proteins) activity, with implications for PBF as a prognostic indicator for invasive tumors.

  2. These findings indicate that miR (show MLXIP Proteins)-584 suppresses glioma cell growth by negatively regulating the expression of PTTG1IP, suggesting that miR (show MLXIP Proteins)-584 has a tumor suppressive role in human glioma pathogenesis.

  3. protooncogene PBF is a negative regulator of p53 (show TP53 Proteins) function in thyroid tumorigenesis, in which PBF is generally overexpressed and p53 (show TP53 Proteins) mutations are rare compared with other tumor types

  4. Data from mutant recombinant proteins suggest that proto-oncogene PBF is a phosphoprotein and highlight importance of tyrosine residue Y174 in both endocytosis of PBF and its interaction/co-localization with NIS/SLC5A5 (sodium-iodide symporter).

  5. PBF expression may be a promising biomarker for prognostic and therapeutic purposes in papillary thyroid carcinoma patients.

  6. Authors identified pituitary tumor-transforming gene 1 (PTTG1 (show PTTG1 Proteins)) binding factor (PBF) as a target of miR (show MLXIP Proteins)-122 and demonstrated that hepatitis B virus replication causes an obvious increase in PBF levels.

  7. The present study provides the first epidemiological evidence that functional regulatory variants of PTTG1IP were associated with the risk of ER-positive breast cancer, further supporting its relevance as one proto-oncogene (show RAB1A Proteins) in breast cancer.

  8. overexpression of PBF causes thyroid cell proliferation, macrofollicular lesions, and hyperplasia, as well as repression of the critical therapeutic route for radioiodide uptake

  9. PTTG (show PTTG1 Proteins) expression was higher in malignant cells than in primary astrocytes, whereas PTTG-binding factor was not in astrocytoma

  10. overexpression of PTTG and PBF in differentiated thyroid cancer has profound implications for activity of the NIS gene, and hence significantly impacts upon the efficacy of radioiodine treatment.

PTTG1IP Protein Profile

Protein Summary

The encoded protein, which directly binds to pituitary tumor-transforming gene 1 protein (PTTG1), facilitates the nuclear translocation of PTTG1 and potentiates the transcriptional activation of basic fibroblast growth factor by PTTG1. The gene product localizes to both the cytoplasm and nucleus. Its NLS is required for its own nuclear localization, the nuclear localization of PTTG1, and its interaction with PTTG1.

Gene names and symbols associated with PTTG1IP

  • pituitary tumor-transforming 1 interacting protein (Pttg1ip)
  • pituitary tumor-transforming 1 interacting protein (PTTG1IP)
  • pituitary tumor-transforming gene 1 protein-interacting protein-like (LOC100624320)
  • 1810010L20Rik protein
  • AI314311 protein
  • AU018448 protein
  • C21orf1 protein
  • C21orf3 protein
  • C79540 protein
  • PBF protein

Protein level used designations for PTTG1IP

PBF , PTTG-binding factor , pituitary tumor-transforming gene 1 protein-interacting protein , pituitary tumor-transforming gene protein-binding factor

GENE ID SPECIES
108705 Mus musculus
365548 Rattus norvegicus
754 Homo sapiens
100717897 Cavia porcellus
617245 Bos taurus
420545 Gallus gallus
100174140 Pongo abelii
100624320 Sus scrofa
Selected quality suppliers for PTTG1IP Proteins (PTTG1IP)
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