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PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008].. Additionally we are shipping PIWIL2 Antibodies (59) and and many more products for this protein.
zili might have some effect on the formation of the ectoderm, mesoderm and endoderm during early embryogenesis
Tdrd1 binds both zebrafish Piwi (show PIWIL1 ELISA Kits) proteins, Ziwi (show PIWIL1 ELISA Kits) and Zili, and reveals sequence specificity in the interaction between Tdrd1 tudor domains and symmetrically dimethylated arginines (sDMAs) in Zili.
These results indicate that zili regulates dorsal-ventral patterning by antagonizing Bmp signaling during early embryogenesis in zebrafish.
Zebrafish piwil2 is a mediator of Fgf signals in gastrula period.
data presented show that Zili suppresses TGF-beta (show TGFB1 ELISA Kits) signaling by physically associating with Smad4 (show SMAD4 ELISA Kits) and preventing the formation of Smad2 (show SMAD2 ELISA Kits)/3/4 and Smad1 (show SMAD1 ELISA Kits)/5/9/4 complexes
Ziwi (show PIWIL1 ELISA Kits) and Zili bind piRNAs of opposite polarity
MILI is responsible for DNA methylation (show HELLS ELISA Kits) of a larger subset of TE families than MIWI2 (show PIWIL4 ELISA Kits).
piRNA biogenesis triggered by PIWI slicing, and promoted by EXD1, ensures that the same guides instruct PIWI proteins in the nucleus and cytoplasm.
Knockdown of MILI in B16 cell line could activate MAGEA expression and increase the cell migration ability, whereas the overexpression of MILI in B16BL6 cell line could inhibit MAGEA expression and decrease the cell migration ability.
Report shows that fly Aub, Bombyx mori Siwi, and mouse MILI select targets bearing a t1A (show PDPN ELISA Kits) nucleotide irrespective of the identity of the g1 nucleotide of their piRNA guide.
Mice with a global deletion of all three piwi (show PIWIL1 ELISA Kits) genes, Miwi (show PIWIL1 ELISA Kits), Mili, and Miwi2 (show PIWIL4 ELISA Kits), are able to maintain long-term hematopoiesis with no observable effect on the homeostatic hematopoietic stem cells compartment in adult mice.
The in vitro studies show estrogen can downregulate the expression of miwi (show PIWIL1 ELISA Kits) and mili.
characterize the genome-wide target RNA repertoire of Mili (Piwil2) and Miwi (Piwil1 (show PIWIL1 ELISA Kits)), two Piwi (show PIWIL1 ELISA Kits) proteins expressed in postnatal testis
a new role for Piwil2 in DNA repair
cycles of intra-Mili secondary piRNA biogenesis fuel piRNA amplification that is absolutely required for LINE1 silencing
The results suggest broader roles for Piwil2 in genome surveillance beyond the germ line and a possible role in regulating the cell cycle of mesenchymal stem cells.
MMP9 (show MMP9 ELISA Kits) and PIWIL2 expression levels in cancerous tissues were significantly higher than the adjacent normal tissues
PIWIL2 has a role in promoting progression of non-small cell lung cancer by inducing CDK2 (show CDK2 ELISA Kits) and Cyclin A (show CCNA2 ELISA Kits) expression
Piwil 2 expression is correlated with disease-specific and progression-free survival of chemotherapy-treated bladder cancer patients
Univariate analysis demonstrated that high PIWIL2 expression was associated with shorter survival time after radical resection.
Knockdown of Piwil2 gene in SiHa cells inhibited cell growth and invasion, and downregulated matrix metalloproteinase-9 (MMP-9 (show MMP9 ELISA Kits)) compared to scrambled shRNA transfected cells
Results show that both PIWIL2 protein isoforms are expressed in testicular germ cell lines but in the tumors, the short protein and mRNA are predominant and highly expressed in undifferentiated tumors.
Our results indicate a reciprocal regulation between HIWI (show PIWIL1 ELISA Kits), HILI and some CSCs markers in colorectal cancer
PIWIL2 modulates tumor cell proliferation and F-actin filaments by interacting with NME2 and regulating c-Myc (show MYC ELISA Kits) expression.
This study revealed critical negative regulation of TGF-beta (show TGFB1 ELISA Kits) signalling by PIWIL2 in HepG2 tumour cells.
Study indicates that Piwil2 plays a role in Fas (show FAS ELISA Kits)-mediated apoptosis and can affect p53 (show TP53 ELISA Kits) phosphorylation in tumor cells, revealing a novel mechanism of Piwil2 in apoptosis, and supports that Piwil2 plays an active role in tumorigenesis.
PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003
piwi-like protein 2
, piwi like 2
, Miwi like
, Miwi likw
, piwi like homolog 2
, piwi-like homolog 2
, cancer/testis antigen 80
, piwi-like 2
, piwil2-like protein