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PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008].. Additionally we are shipping PIWIL4 Antibodies (53) and PIWIL4 Proteins (3) and many more products for this protein.
PIWIL4 is highly expressed in both breast cancer tissues and the cytoplasm of MDA-MB-231 cells derived from breast cancer. Reducing PIWIL4 expression drastically impairs the migration ability of MDA-MB-231 cells, significantly increases their apoptosis, and mildly affects their proliferation.
Results show that three CpG loci within FYN (show FYN ELISA Kits) were hypermethylated in obese individuals, while obesity was associated with lower methylation of CpG loci within PIWIL4 and TAOK3 (show TAOK3 ELISA Kits).
study to evaluate frequency of PIWIL4 genetic variants in order to better define the relationship between PIWIL4 SNPs and defective spermatogenesis and specific spermatogenic disorders; results suggest genetic and epigenetic alterations that affect the PIWI pathway contribute to unsuccessful sperm production
Data suggest that MIWI2 and MIWI2-associated piRNAs have functions beyond TE suppression.
associations were determined between the Piwi-like family member expression levels and clinicopathological parameters of ccRCC, suggesting a potential role for these genes/proteins in ccRCC diagnostics and tumorigenesis
we identified a significant association between the expression of Piwi-like 2 (show PIWIL2 ELISA Kits) and 4 mRNAs and the tumor-specific survival of soft tissue sarcoma patients.
PIWIL4 might play an oncogenic role in cervical cancer
An SNP in the 3'untranslated region of HIWI2 and a non-synonymous SNP in HIWI3 were significantly associated with an altered risk of oligozoospermia.
EIF2C2 (show EIF2C2 ELISA Kits)-4 and PIWIL4 appear increased in advanced tumors with distant metastasis, suggesting they may promote tumor invasion
PIWIL4 plays important roles in the chromatin-modifying pathway in human somatic cells
Miwi2 deficiency had only a minor impact on piRNA biogenesis. Miwi2-knockout mice indicated overexpression of several LINE1 TE families.
piRNA biogenesis triggered by PIWI slicing, and promoted by EXD1, ensures that the same guides instruct PIWI proteins in the nucleus and cytoplasm.
MIWI2 is not solely necessary for hematopoiesis within the normal life span of a mouse.
Mice with a global deletion of all three piwi (show PIWIL1 ELISA Kits) genes, Miwi (show PIWIL1 ELISA Kits), Mili (show PIWIL2 ELISA Kits), and Miwi2, are able to maintain long-term hematopoiesis with no observable effect on the homeostatic hematopoietic stem cells compartment in adult mice.
Icariin induced a decrease in piwil4 protein expression and piwil4 silencing significantly enhanced the cytotoxic effects of icariin in MLTC-1 cells.
Results identify TDRD9 as a functional partner of MIWI2 and indicate that the tudor-piwi association is a conserved feature, while two separate axes, TDRD9-MIWI2 and TDRD1-MILI, cooperate in the piwi-small RNA pathway in the mouse male germline.
Data strongly suggest that MILI (show PIWIL2 ELISA Kits) and MIWI2 play essential roles in establishing de novo DNA methylation (show HELLS ELISA Kits) of retrotransposons in fetal male germ cells.
purified the three murine Piwi (show PIWIL1 ELISA Kits) family proteins, MILI (show PIWIL2 ELISA Kits), MIWI (show PIWIL1 ELISA Kits), and MIWI2, from mouse germ cells and characterized their interacting protein partners
PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003
, piwi-like protein 4
, piwi-like homolog 4