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May play a role in placental development (By similarity).. Additionally we are shipping Placenta-Specific 1 Kits (6) and Placenta-Specific 1 Proteins (4) and many more products for this protein.
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Optimized protocol for soluble prokaryotic expression, purification and structural analysis of human placenta specific-1(PLAC1).
we show that PLAC1 transcript number is significantly negatively correlated with patient survival in our samples. Thus, we suggest that characterizing tumors for TP53 (show TP53 Antibodies) mutation status, p53 (show TP53 Antibodies) protein status and PLAC1 transcription could be used to predict likely prognosis and inform treatment options in patients diagnosed with serous ovarian cancer.
This study demonstrated that the protein expression of PLAC1 was significantly associated with decreased overall survival in patients with pancreatic ductal adenocarcinoma, indicating that it was a valuable prognostic marker for pancreatic ductal adenocarcinoma and might be a potential target for immunotherapy.
Plac1 plays a pivotal role in the progression of HCC (show FAM126A Antibodies), and may serve as a novel therapeutic target for Hepatocellular carcinoma.
PLAC1 was mainly expressed in the human villous syncytiotrophoblast (STB) layer throughout gestation, and the expression level of PLAC1 was significantly elevated during human trophoblast syncytialization.
PLAC1/CP1 provides a marker for identifying gastric cancers with poor prognosis, and suggest that PLAC1/CP1 may provide a useful target for immunotherapy.
Data suggests that PLAC1 plays an important role in human placental trophoblast invasion and migration.
This data suggests that the Epstein-Barr virus-induced PLAC1 is a member of the cancer/testis group of tumor antigens.
PLAC1/CP1 antigen is a possible prognostic marker of colorectal carcinoma, and PLAC1/CP1 p41 (show EPB41 Antibodies)-50 and PLAC1/CP1 p69 (show ICA1 Antibodies)-77 are novel HLA-A*0201-restricted CD8 (show CD8A Antibodies)+ T cell epitopes
NCOA3 (show NCOA3 Antibodies) is a selective co-activator of estrogen receptor alpha (show ESR1 Antibodies)-mediated transactivation of PLAC1.
Our findings suggest that Plac1 is involved in trophoblast cell proliferation, differentiation, and migration
Plac1 (placenta-specific 1) is widely expressed during fetal development and is associated with a lethal form of hydrocephalus.
Plac1 is a paternally imprinted, X-linked gene essential for normal placental and embryonic development.
May play a role in placental development (By similarity).
, placenta-specific protein 1
, cancer/testis antigen 92
, ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 26