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anti-Plakophilin 2 (PKP2) Antibodies

PKP2 encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Additionally we are shipping Plakophilin 2 Kits (21) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PKP2 5318 Q99959
PKP2 67451  
PKP2 287925  
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Top anti-Plakophilin 2 Antibodies at antibodies-online.com

Showing 10 out of 71 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-PKP2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: COLO205 cell lysate WB Suggested Anti-PKP2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: COLO205 cell lysate  PKP2 is supported by BioGPS gene expression data to be expressed in COLO205 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue reacte with Plakophilin-2 Antibody (C-term) followed whcih was peroxidase conjugated to the secondary antibody and followed by DAB staining.This data demonstrates the use of PKP2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. Western blot analysis of Plakophilin-2 Antibody (C-term) in K562 cell line lysates (35ug/lane). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HeLa/HepG2 cells, using PKP2 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Mouse Mouse Un-conjugated IHC (p), IP, WB 0.1 mL Log in to see 5 to 6 Days
$455.84
Details
Human Mouse Un-conjugated IF, IP, IHC, WB Western blot analysis of Plakophilin 2 on a HepG2 cell lysate (Human hepatocellular carcinoma, ATCC HB-8065). Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the mouse anti-human Plakophilin 2 antibody. Immunofluorescence staining of HL-60 cells (Human promyelocytic leukemia, ATCC CCL-240). 50 μg Log in to see 5 to 6 Days
$205.42
Details
Cow Mouse Un-conjugated IHC (fro), IHC (p), IP, WB   5 mL Log in to see 6 to 8 Days
$313.50
Details
Human Rabbit Un-conjugated IHC (p), WB PKP2 Antibody (C-term)  western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the PKP2 antibody detected the PKP2 protein (arrow). PKP2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PKP2 Antibody (C-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Cow Goat Un-conjugated EIA, WB AP23756PU-N Plakophilin-2 antibody staining of Mouse Heart lysate at 0.3 µg/ml (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Mouse Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$200.00
Details

PKP2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Plakophilin 2 Antibodies

  1. Cow (Bovine) Monoclonal Plakophilin 2 Primary Antibody for IHC (fro), IHC (p) - ABIN112248 : Akat, Mennel, Kremer, Gassler, Bleck, Kartenbeck: Molecular characterization of desmosomes in meningiomas and arachnoidal tissue. in Acta neuropathologica 2003 (PubMed)
    Show all 7 references for ABIN112248

  2. Human Polyclonal Plakophilin 2 Primary Antibody for EIA, IHC (p) - ABIN954172 : Fressart, Duthoit, Donal, Probst, Deharo, Chevalier, Klug, Dubourg, Delacretaz, Cosnay, Scanu, Extramiana, Keller, Hidden-Lucet, Simon, Bessirard, Roux-Buisson, Hebert, Azarine, Casset-Senon, Rouzet, Lecarpentier, Fontaine, Coirault, Frank, Hainque, Charr: Desmosomal gene analysis in arrhythmogenic right ventricular dysplasia/cardiomyopathy: spectrum of mutations and clinical impact in practice. in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2010 (PubMed)
    Show all 4 references for ABIN954172

  3. Human Polyclonal Plakophilin 2 Primary Antibody for ELISA, WB - ABIN1535176 : Rikova, Guo, Zeng, Possemato, Yu, Haack, Nardone, Lee, Reeves, Li, Hu, Tan, Stokes, Sullivan, Mitchell, Wetzel, Macneill, Ren, Yuan, Bakalarski, Villen, Kornhauser, Smith, Li, Zhou, Gygi, Gu et al.: Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. ... in Cell 2007 (PubMed)
    Show all 2 references for ABIN1535176

  4. Human Polyclonal Plakophilin 2 Primary Antibody for WB - ABIN2786784 : Bass-Zubek, Hobbs, Amargo, Garcia, Hsieh, Chen, Wahl, Denning, Green: Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly. in The Journal of cell biology 2008 (PubMed)

  5. Human Monoclonal Plakophilin 2 Primary Antibody for IF, IP - ABIN968178 : Mertens, Kuhn, Franke: Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque. in The Journal of cell biology 1997 (PubMed)

  6. Mouse (Murine) Monoclonal Plakophilin 2 Primary Antibody for IHC (p), IP - ABIN1169700 : Sobolik-Delmaire, Reddy, Pashaj, Roberts, Wahl: Plakophilin-1 localizes to the nucleus and interacts with single-stranded DNA. in The Journal of investigative dermatology 2010 (PubMed)

More Antibodies against Plakophilin 2 Interaction Partners

Human Plakophilin 2 (PKP2) interaction partners

  1. Extreme variability in clinical penetrance for a splice-site PKP2 mutation was found in a Bangladeshi family. Some family members were affected by arrhythmogenic right ventricular cardiomyopathy, and some are asymptomatic.

  2. Data suggest juxtamembrane regions/domains of desmocollin-2 (DSC2 (show DSC2 Antibodies)), plakophilin 2 (PKP2), and plakophilin 3 (PKP3 (show PKP3 Antibodies)) are involved in desmosome formation in epithelial cells; DSC2 (show DSC2 Antibodies) participates in desmosome formation in absence of desmoglein 2 (DSG2 (show DSG2 Antibodies)).

  3. PKP2 regulates Wnt (show WNT2 Antibodies) activity during adipogenic and cardiomyogenic differentiation in arrhythmogenic right ventricular cardiomyopathy.

  4. A heterozygous pathogenic variant in the plakophilin-2 (c.2392A>G, p.T798A) gene was found in an arrhythmogenic LV cardiomyopathy patient and his deceased mother who had had arrhythmogenic cardiomyopathy affecting both ventricles.

  5. Six variants of uncertain clinical significance in the PKP2, JUP (show JUP Antibodies), and DSG2 (show DSG2 Antibodies) genes showed a deleterious effect on mRNA splicing, indicating these are ARVD (show TGFB3 Antibodies)/C-related pathogenic splice site mutations.

  6. Exercise test is valuable for the diagnosis of ARVC in patients with PKP2 gene mutation.

  7. Case Report: PKP2/DSP (show DSP Antibodies) mutations in patient with Brugada syndrome and ventricular tachycardia.

  8. The introduction of the PKP2 R735X mutation into mice resulted in an exercise-dependent arrhythmogenic right ventricular cardiomyopathy.

  9. PKP2 haploinsufficiency contributes to pathogenesis in arrhythmogenic cardiomyopathy.

  10. mutations in PKP2 are associated with a later age of onset of arrhythmogenic right ventricular cardiomyopathy

Mouse (Murine) Plakophilin 2 (PKP2) interaction partners

  1. Plakophilin-2 loss promotes TGF-beta1 (show TGFB1 Antibodies)/p38 MAPK (show MAPK14 Antibodies)-dependent fibrotic gene expression in cardiomyocytes.

  2. Missense mutations in plakophilin-2 cause sodium current deficit and associate with a Brugada syndrome phenotype.

  3. PKP2 haploinsufficiency leads to I(Na) deficit in murine hearts which may contribute to generation and/or maintenance of arrhythmias.

  4. plakophilin 2 is important for the assembly of junctional proteins and represents an essential morphogenic factor and architectural component of the heart

  5. By providing an extra link between the cadherin-catenin complex and intermediate filaments, the binding of alphaT-catenin to plakophilin-2 is proposed to be a means of modulating and strengthening cell-cell adhesion between cardiac muscle cells.

Cow (Bovine) Plakophilin 2 (PKP2) interaction partners

  1. PKP2 increased connexin 43 (show GJA1 Antibodies), a gap junction protein, while its knockdown inhibited embryo implantation in mice.

Plakophilin 2 (PKP2) Antigen Profile

Protein Summary

This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13.

Gene names and symbols associated with anti-Plakophilin 2 (PKP2) Antibodies

  • plakophilin 2 (PKP2) antibody
  • plakophilin 2 (Pkp2) antibody
  • plakophilin 2 (LOC100347738) antibody
  • 1200008D14Rik antibody
  • 1200012P04Rik antibody
  • AA516617 antibody
  • ARVD9 antibody
  • Pkp2l antibody

Protein level used designations for anti-Plakophilin 2 (PKP2) Antibodies

plakophilin-2

GENE ID SPECIES
100070065 Equus caballus
5318 Homo sapiens
67451 Mus musculus
287925 Rattus norvegicus
537784 Bos taurus
486613 Canis lupus familiaris
100347738 Oryctolagus cuniculus
100728409 Cavia porcellus
100526169 Sus scrofa
418130 Gallus gallus
101104733 Ovis aries
Selected quality suppliers for anti-Plakophilin 2 (PKP2) Antibodies
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