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PKP3 encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Additionally we are shipping Plakophilin 3 Antibodies (92) and Plakophilin 3 Proteins (4) and many more products for this protein.
Children with low 25-hydroxyvitamin D and TMEM16J (show ANO9 ELISA Kits) rs7111432-AA or PKP3 rs10902158-GG polymorphisms were at increased risk for tuberculosis or death.
Data suggest juxtamembrane regions/domains of desmocollin-2 (DSC2 (show DSC2 ELISA Kits)), plakophilin 2 (PKP2 (show PKP2 ELISA Kits)), and plakophilin 3 (PKP3) are involved in desmosome formation in epithelial cells; DSC2 (show DSC2 ELISA Kits) participates in desmosome formation in absence of desmoglein 2 (DSG2 (show DSG2 ELISA Kits)).
The results suggest that MMP7 (show MMP7 ELISA Kits) over-expression may be one of the mechanisms by which PKP3 loss leads to increased cell invasion and tumor formation.
reactive oxygen species (ROS (show ROS1 ELISA Kits)) trigger the c-Src kinase (show CSK ELISA Kits)-mediated tyrosine (Tyr (show TYR ELISA Kits))-195 phosphorylation of PKP3.
These findings reveal Pkp3 as a coordinator of desmosome and adherens junction assembly and maturation through its functional association with Rap1.
cytoplasmic PKP1 (show PKP1 ELISA Kits)/3 are components of mRNA ribonucleoprotein (show RBP31 ELISA Kits) particles and act as posttranscriptional regulators of gene expression.
Pemphigus vulgaris (show DSG3 ELISA Kits) autoimmune globulin induces Src (show SRC ELISA Kits)-dependent tyrosine-phosphorylation of PKP3 and its detachment from DSG3 (show DSG3 ELISA Kits).
The study describes a new protein variant of the human PKP3 gene, namely PKP3b, which differs from the published PKP3a only at the amino-terminus by the splicing in of the newly identified exon 1b.
stratifin (show SFN ELISA Kits) plays a role in regulating plakophilin-3 incorporation into the desmosomal plaque by forming a plakophilin-3 stratifin (show SFN ELISA Kits) complex in the cytosol and thereby affecting desmosome dynamics in squamous epithelial cells.
In breast cancer, compared with normal tissue, PKP1 (show PKP1 ELISA Kits) and PKP2 (show PKP2 ELISA Kits) expressions were indifferent (P > 0.05), but PKP3 expression was significantly increased
data highlight a novel role for hematopoietic PKP3 in the regulation of both locally and systemically induced immune responses.
PKP3 gene down regulation is associated with bladder cancer invasion.
PKP3 plays a critical role in morphogenesis of HFs and shafts and in limiting inflammatory responses in the skin
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways.
, plakophilin 3b