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PLAT encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Additionally we are shipping PLAT Kits (78) and PLAT Proteins (72) and many more products for this protein.
Showing 10 out of 321 products:
Human Monoclonal PLAT Primary Antibody for ELISA (Detection), WB - ABIN491295
Bestman, Cline: The RNA binding protein CPEB regulates dendrite morphogenesis and neuronal circuit assembly in vivo. in Proceedings of the National Academy of Sciences of the United States of America 2008
Human Polyclonal PLAT Primary Antibody for EIA, IHC (fro) - ABIN191536
Coy, Jiménez-Movilla, García-Vázquez, Mondéjar, Grullón, Romar: Oocytes use the plasminogen-plasmin system to remove supernumerary spermatozoa. in Human reproduction (Oxford, England) 2012
Human Polyclonal PLAT Primary Antibody for IF (p), IHC (p) - ABIN731123
Balaoing, Post, Liu, Minn, Grande-Allen: Age-related changes in aortic valve hemostatic protein regulation. in Arteriosclerosis, thrombosis, and vascular biology 2013
Human Polyclonal PLAT Primary Antibody for EIA, WB - ABIN453432
de Vos, Ultsch, Kelley, Padmanabhan, Tulinsky, Westbrook, Kossiakoff: Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution. in Biochemistry 1992
we reviewed current knowledge of mechanisms by which tPA can influence brain function in physiological and pathological conditions--REVIEW}
This study examines the complexes of PAI-1 (show SERPINE1 Antibodies) with tissue-type and urokinase-type plasminogen activator (show PLAU Antibodies) and vitronectin (show VTN Antibodies) revealed by changes in the conformation and dynamics of the reactive center loop.
Data suggest that baseline levels of adiponectin, C-reactive protein, TPA, and fibrinogen or changes in these levels do not explain increased risk of diabetes type 2 in overweight women with glucose intolerance and histories of gestational diabetes.
Tissue plasminogen activator (tPA) may be a general factor in the immunological response to viruses.
tPA has a role in progression of periventricular white matter hyperintensities
These data indicate that oxygen-glucose deprivation-triggered Cav-1 (show CAV1 Antibodies) S-nitrosylation interacts with tPA-induced ERK (show EPHB2 Antibodies) activation to augment MMP2 (show MMP2 Antibodies) and 9 secretion and subsequent extracellular matrix degradation.
tPA-dependent activation of EGFRs leads to downregulation of NMDAR (show GRIN1 Antibodies) signaling and to subsequent neurotrophic effects.
Among patients with elevated concentrations of the CA 15-3, CEA (show CEACAM5 Antibodies), and TPA concordance could be observed between serial changes of the hypermethylated RASSF1A (show RASSF1 Antibodies) gene and the protein markers
Patients in the acute stage of ischemic stroke had significantly increased levels of t-PA activity and beta-TG (show PPBP Antibodies) content, but PAI-1 (show SERPINE1 Antibodies) activity was significantly decreased
Tissue-type plasminogen activator-binding RNA aptamers inhibiting low-density lipoprotein receptor (show LDLR Antibodies) family-mediated internalization may improve safety of thrombolytic therapy.
strategies contributing to promote either endogenous production of tPA or its associated EGFR (show EGFR Antibodies)-linked signaling pathway may have beneficial effects following brain injuries such as stroke.
Plasminogen (show PLG Antibodies) activation contributes to wound repair and suggest that adenosine A2A receptor (show ADORA2A Antibodies) activation promotes wound closure by a mechanism that depends on tPA.
Myeloid-derived Tissue-type plasminogen activator (tPA) promotes macrophage migration through a novel signaling cascade involving FAK (show PTK2 Antibodies), Rac-1, and NF-kappaB (show NFKB1 Antibodies).
the protective effect of neuroserpin (show SERPINI1 Antibodies) maybe independent from its canonical interaction with a tissue-type plasminogen activator
Erythropoietin (show EPO Antibodies) protects mouse renal tubular basement membrane by promoting bone marrow cells to generate and secrete miR (show MLXIP Antibodies)-144, which, in turn, inhibits activation of the tPA/MMP9 (show MMP9 Antibodies)-mediated proteolytic network.
tPA activity in V1 can be unmasked following 4 d of monocular deprivation when mice older than 2 months are raised in standard cages by the genetic removal of Lynx1 (show LYNX1 Antibodies), a negative regulator of adult plasticity.
Study shows that the competitive expression or activity of tPA and/or PAI-1 (show SERPINE1 Antibodies), rather than an altered uPA (show PLAU Antibodies) expression, determines the plasmin (show PLG Antibodies)-mediated Abeta (show APP Antibodies) proteolysis in brains affected by Alzheimer's disease
Results demonstrate that synaptic potentiation results in tissue plasminogen activator-dependent reelin (show RELN Antibodies) processing and suggest that extracellular proteolysis of reelin (show RELN Antibodies) may regulate reelin (show RELN Antibodies) signaling in the adult brain
data implicate MCP-1 (show CPT1B Antibodies) as the key molecule governing tPA-induced fluid accumulation. The role of MCP-1 (show CPT1B Antibodies) in the development of other exudative effusions warrants examination.
Data indicated that suggest that tPA modulates emotion in a social context through the function of the prefrontal cortex.
The plasminogen/plasminogen (show PLG Antibodies) activator/plasmin (show PLG Antibodies) system is activated during gamete interaction and regulates the sperm entry into the oocyte.
Mild experimental hypothermia markedly reduces ischemia-related coronary tissue plasminogen activator release, which may contribute to the cardioprotective effect of hypothermia.
a fast beta2 agonist-mediated local release of t-PA into the coronary vasculature was demonstrated. For total t-PA, this response was characterised by a biphasic release profile
ADP acting on the endothelial P2Y(1) M receptor may mediate release of t-PA during ischemia and post-ischemic hyperemia, an effect that may counteract some of the platelet activating effects of ADP
stage-dependent regulation of granulosa cell PA and SerpinE2 (show SERPINE2 Antibodies) production, consistent with a role in extracellular matrix remodeling during follicle growth
These results suggest that Neovastat induces tPA gene transcription through activation of the JNK (show MAPK8 Antibodies) and NFkappaB signaling pathways, leading to an increase of tPA secretion by endothelial cells.
This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding\; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
plasminogen activator, tissue
, plasminogen activator, tissue type
, tissue-type plasminogen activator
, t-plasminogen activator
, tissue-type plasminogen activator-like
, tissue plasminogen activator (t-PA)
, tissue plasminogen activator
, T-plasminogen activator