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Plasminogen Activator, Tissue Proteins (PLAT)

PLAT encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Additionally we are shipping PLAT Antibodies (295) and PLAT Kits (94) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PLAT 5327 P00750
PLAT 18791 P11214
PLAT 25692 P19637
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Top PLAT Proteins at antibodies-online.com

Showing 10 out of 64 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Fc Tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Insect Cells Human Un-conjugated   0.1 mg Log in to see 2 to 3 Days
$385.00
Details
Insect Cells Mouse Un-conjugated   0.1 mg Log in to see 2 to 3 Days
$385.00
Details
HOST_CHO Human FITC   0.1 mg Log in to see 2 to 3 Days
$506.00
Details
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 11 to 13 Days
$739.20
Details
HOST_Human Cells Mouse Fc Tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_CHO Human Un-conjugated   0.1 mg Log in to see 2 to 3 Days
$264.00
Details

PLAT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
, , , , , ,
Mouse (Murine) , ,
, , , ,
Rat (Rattus) , ,
,

Top referenced PLAT Proteins

  1. Mouse (Murine) PLAT Protein expressed in Insect Cells - ABIN491605 : Lin, Jin, Mars, Reeves, Hu: Myeloid-derived tissue-type plasminogen activator promotes macrophage motility through FAK, Rac1, and NF-?B pathways. in The American journal of pathology 2014 (PubMed)
    Show all 9 references for ABIN491605

  2. Human PLAT Protein expressed in CHO - ABIN491596 : Harr, Moore, Chin, Chapman, Ghasabyan, Stringham, Banerjee, Silliman: Viscoelastic hemostatic fibrinogen assays detect fibrinolysis early. in European journal of trauma and emergency surgery : official publication of the European Trauma Society 2015 (PubMed)
    Show all 5 references for ABIN491596

  3. Human PLAT Protein expressed in Human Cells - ABIN2002195 : Boose, Kuismanen, Gerard, Sambrook, Gething: The single-chain form of tissue-type plasminogen activator has catalytic activity: studies with a mutant enzyme that lacks the cleavage site. in Biochemistry 1989 (PubMed)
    Show all 5 references for ABIN2002195

  4. Human PLAT Protein expressed in Insect Cells - ABIN491598 : Mantuano, Lam, Shibayama, Campana, Gonias: The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration. in Journal of cell science 2015 (PubMed)
    Show all 2 references for ABIN491598

  5. Human PLAT Protein expressed in CHO - ABIN491026 : Komissarov, Florova, Idell: Effects of extracellular DNA on plasminogen activation and fibrinolysis. in The Journal of biological chemistry 2011 (PubMed)

More Proteins for Plasminogen Activator, Tissue (PLAT) Interaction Partners

Human Plasminogen Activator, Tissue (PLAT) interaction partners

  1. Data suggest that baseline levels of adiponectin, C-reactive protein, TPA, and fibrinogen or changes in these levels do not explain increased risk of diabetes type 2 in overweight women with glucose intolerance and histories of gestational diabetes.

  2. Tissue plasminogen activator (tPA) may be a general factor in the immunological response to viruses.

  3. tPA has a role in progression of periventricular white matter hyperintensities

  4. These data indicate that oxygen-glucose deprivation-triggered Cav-1 (show CAV1 Proteins) S-nitrosylation interacts with tPA-induced ERK (show EPHB2 Proteins) activation to augment MMP2 (show MMP2 Proteins) and 9 secretion and subsequent extracellular matrix degradation.

  5. tPA-dependent activation of EGFRs leads to downregulation of NMDAR (show GRIN1 Proteins) signaling and to subsequent neurotrophic effects.

  6. Among patients with elevated concentrations of the CA 15-3, CEA (show CEACAM5 Proteins), and TPA concordance could be observed between serial changes of the hypermethylated RASSF1A (show RASSF1 Proteins) gene and the protein markers

  7. Patients in the acute stage of ischemic stroke had significantly increased levels of t-PA activity and beta-TG (show PPBP Proteins) content, but PAI-1 (show SERPINE1 Proteins) activity was significantly decreased

  8. Tissue-type plasminogen activator-binding RNA aptamers inhibiting low-density lipoprotein receptor (show LDLR Proteins) family-mediated internalization may improve safety of thrombolytic therapy.

  9. report the crystal structure of the tPA.PAI-1 Michaelis complex, which shows significant differences from the structure of its urokinase-type plasminogen activator (show PLAU Proteins) analogue, the uPA.PAI-1 Michaelis complex

  10. Intravenous tissue plasminogen activator therapy was associated with improved clinical outcomes without significant increase in risk of hemorrhagic complications in very old patients (aged>80 years) with acute ischemic stroke.

Mouse (Murine) Plasminogen Activator, Tissue (PLAT) interaction partners

  1. strategies contributing to promote either endogenous production of tPA or its associated EGFR (show EGFR Proteins)-linked signaling pathway may have beneficial effects following brain injuries such as stroke.

  2. Plasminogen (show PLG Proteins) activation contributes to wound repair and suggest that adenosine A2A receptor (show ADORA2A Proteins) activation promotes wound closure by a mechanism that depends on tPA.

  3. Myeloid-derived Tissue-type plasminogen activator (tPA) promotes macrophage migration through a novel signaling cascade involving FAK (show PTK2 Proteins), Rac-1, and NF-kappaB (show NFKB1 Proteins).

  4. the protective effect of neuroserpin (show SERPINI1 Proteins) maybe independent from its canonical interaction with a tissue-type plasminogen activator

  5. Erythropoietin (show EPO Proteins) protects mouse renal tubular basement membrane by promoting bone marrow cells to generate and secrete miR (show MLXIP Proteins)-144, which, in turn, inhibits activation of the tPA/MMP9 (show MMP9 Proteins)-mediated proteolytic network.

  6. tPA activity in V1 can be unmasked following 4 d of monocular deprivation when mice older than 2 months are raised in standard cages by the genetic removal of Lynx1 (show LYNX1 Proteins), a negative regulator of adult plasticity.

  7. Study shows that the competitive expression or activity of tPA and/or PAI-1 (show SERPINE1 Proteins), rather than an altered uPA (show PLAU Proteins) expression, determines the plasmin (show PLG Proteins)-mediated Abeta (show APP Proteins) proteolysis in brains affected by Alzheimer's disease

  8. Results demonstrate that synaptic potentiation results in tissue plasminogen activator-dependent reelin (show RELN Proteins) processing and suggest that extracellular proteolysis of reelin (show RELN Proteins) may regulate reelin (show RELN Proteins) signaling in the adult brain

  9. data implicate MCP-1 (show CPT1B Proteins) as the key molecule governing tPA-induced fluid accumulation. The role of MCP-1 (show CPT1B Proteins) in the development of other exudative effusions warrants examination.

  10. Data indicated that suggest that tPA modulates emotion in a social context through the function of the prefrontal cortex.

Pig (Porcine) Plasminogen Activator, Tissue (PLAT) interaction partners

  1. The plasminogen/plasminogen (show PLG Proteins) activator/plasmin (show PLG Proteins) system is activated during gamete interaction and regulates the sperm entry into the oocyte.

  2. Mild experimental hypothermia markedly reduces ischemia-related coronary tissue plasminogen activator release, which may contribute to the cardioprotective effect of hypothermia.

  3. a fast beta2 agonist-mediated local release of t-PA into the coronary vasculature was demonstrated. For total t-PA, this response was characterised by a biphasic release profile

  4. ADP acting on the endothelial P2Y(1) M receptor may mediate release of t-PA during ischemia and post-ischemic hyperemia, an effect that may counteract some of the platelet activating effects of ADP

Cow (Bovine) Plasminogen Activator, Tissue (PLAT) interaction partners

  1. The plasminogen/plasminogen (show PLG Proteins) activator/plasmin (show PLG Proteins) system is activated during gamete interaction and regulates the sperm entry into the oocyte.

  2. stage-dependent regulation of granulosa cell PA and SerpinE2 (show SERPINE2 Proteins) production, consistent with a role in extracellular matrix remodeling during follicle growth

  3. These results suggest that Neovastat induces tPA gene transcription through activation of the JNK (show MAPK8 Proteins) and NFkappaB signaling pathways, leading to an increase of tPA secretion by endothelial cells.

PLAT Protein Profile

Protein Summary

This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding\; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with PLAT

  • plasminogen activator, tissue (PLAT)
  • plasminogen activator, tissue (plat)
  • tissue-type plasminogen activator (tpa)
  • plasminogen activator, tissue (Plat)
  • AU020998 protein
  • AW212668 protein
  • D8Ertd2e protein
  • PATISS protein
  • Plat protein
  • T-PA protein
  • tPA protein

Protein level used designations for PLAT

plasminogen activator, tissue , plasminogen activator, tissue type , tissue-type plasminogen activator , t-PA , t-plasminogen activator , tPA , tissue-type plasminogen activator-like , alteplase , reteplase , tissue plasminogen activator (t-PA) , tissue plasminogen activator , T-plasminogen activator

GENE ID SPECIES
374183 Gallus gallus
472748 Pan troglodytes
594962 Xenopus (Silurana) tropicalis
704475 Macaca mulatta
100049466 Oryzias latipes
100050239 Equus caballus
100173068 Pongo abelii
100391990 Callithrix jacchus
100542402 Meleagris gallopavo
100586515 Nomascus leucogenys
5327 Homo sapiens
18791 Mus musculus
25692 Rattus norvegicus
397121 Sus scrofa
100725281 Cavia porcellus
100009556 Oryctolagus cuniculus
281407 Bos taurus
482840 Canis lupus familiaris
426791 Gallus gallus
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