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Plasminogen Activator, Urokinase Proteins (PLAU)

PLAU encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. Additionally we are shipping PLAU Antibodies (334) and PLAU Kits (99) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PLAU 5328 P00749
PLAU 18792 P06869
PLAU 25619  
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Top PLAU Proteins at antibodies-online.com

Showing 10 out of 57 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
$173.80
Details
HOST_HEK-293 Human His tag 50 μg Log in to see 2 to 3 Days
$966.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_HEK-293 Cells Human His tag 50 μg Log in to see 2 to 3 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 50 μg Log in to see 2 to 3 Days
$441.00
Details
HOST_Human Human Un-conjugated   0.1 mg Log in to see 2 to 3 Days
$324.50
Details
HOST_Human Human Fluorescein   0.1 mg Log in to see 2 to 3 Days
$528.00
Details
HOST_Escherichia coli (E. coli) Wild boar His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$915.20
Details
Insect Cells Mouse Fluorescein   0.1 mg Log in to see 2 to 3 Days
$1,012.00
Details
Insect Cells Human Un-conjugated   0.1 mg Log in to see 2 to 3 Days
$528.00
Details

PLAU Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , , ,
, , , , ,
Mouse (Murine) ,
, , , ,
Rat (Rattus) , ,

Top referenced PLAU Proteins

  1. Human PLAU Protein expressed in Human - ABIN491612 : Reichel, Uhl, Lerchenberger, Puhr-Westerheide, Rehberg, Liebl, Khandoga, Schmalix, Zahler, Deindl, Lorenzl, Declerck, Kanse, Krombach: Urokinase-type plasminogen activator promotes paracellular transmigration of neutrophils via mac-1, but independently of urokinase-type plasminogen activator receptor. in Circulation 2011 (PubMed)
    Show all 6 references for ABIN491612

  2. Human PLAU Protein expressed in Human Cells - ABIN2003435 : Nagai, Hiramatsu, Kanéda, Hayasuke, Arimura, Nishida, Suyama: Molecular cloning of cDNA coding for human preprourokinase. in Gene 1985 (PubMed)
    Show all 4 references for ABIN2003435

  3. Mouse (Murine) PLAU Protein expressed in Insect Cells - ABIN2544534 : Bryer, Fantuzzi, Van Rooijen, Koh: Urokinase-type plasminogen activator plays essential roles in macrophage chemotaxis and skeletal muscle regeneration. in Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed)

  4. Human PLAU Protein expressed in Insect Cells - ABIN491607 : Wu, Catano, Echeverry, Torre, Haile, An, Chen, Cheng, Nicholson, Tong, Park, Yepes: Urokinase-type plasminogen activator promotes dendritic spine recovery and improves neurological outcome following ischemic stroke. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 (PubMed)

  5. Human PLAU Protein expressed in Human - ABIN491028 : Komissarov, Florova, Idell: Effects of extracellular DNA on plasminogen activation and fibrinolysis. in The Journal of biological chemistry 2011 (PubMed)

More Proteins for Plasminogen Activator, Urokinase (PLAU) Interaction Partners

Human Plasminogen Activator, Urokinase (PLAU) interaction partners

  1. Resveratrol inhibited hypoxia-induced HIF-1alpha (show HIF1A Proteins) protein expression. Resveratrol also suppressed hypoxiainduced expression of metastatic-related factors, uPA (show PRAP1 Proteins) and MMP2 (show MMP2 Proteins).

  2. Significance of the urokinase-type plasminogen activator and its receptor in the progression of focal segmental glomerulosclerosis in clinical and mouse models.

  3. These findings strongly support the use of uPA (show PRAP1 Proteins)/PAI-1 (show SERPINE1 Proteins) together with clinic-pathological parameters as an evidence-based, clinically relevant and inexpensive decision tool in the routine of a breast center.

  4. Data suggest that enhanced levels of uPA (show PRAP1 Proteins) in breast cancer modulate the mitogenic effects of EGF (show EGF Proteins) which helps to better understand breast cancer pathogenesis.

  5. Results found high levels of uPA (show PRAP1 Proteins) and uPAR (show PLAUR Proteins) exclusively in metastatic osteosarcoma (OS)cells and suggest that malignant conversion of OS cells to uPA (show PRAP1 Proteins)/uPAR (show PLAUR Proteins) axis in an autocrine and paracrine fashion.

  6. The morphologically normal tissue adjacent to the tumor shows the substantial expression of MMP-2 (show MMP2 Proteins) and MMP-9 (show MMP9 Proteins) and in some cases the enhanced activity of uPA (show PRAP1 Proteins) and ACE (show ACE Proteins), which makes an additional contribution to the increased invasive potential of tumor

  7. Crystal structure of uPA (show PRAP1 Proteins) bound with cyclic peptidic inhibitors.

  8. data on the stromal macrophages immunoreactivity of uPAR (show PLAUR Proteins), MMP-2 (show MMP2 Proteins), and MMP-9 (show MMP9 Proteins) in a few small cell lung cancer (SCLC) and lung squamous cell carcinoma (SCC (show CYP11A1 Proteins)) biopsies was included. uPAR (show PLAUR Proteins), MMP-2 (show MMP2 Proteins), and MMP-9 (show MMP9 Proteins) were confirmed in stromal cells including macrophages

  9. u-PA is a dysregulated gene involved in the tumorigenesis, bio-pathological features and outcomes of EEC.

  10. High cytoplasmic expression of uPA (show PRAP1 Proteins) is associated with cells of rectal cancer and metastases of perienteric lymph nodes.

Mouse (Murine) Plasminogen Activator, Urokinase (PLAU) interaction partners

  1. Significance of the urokinase-type plasminogen activator and its receptor in the progression of focal segmental glomerulosclerosis in clinical and mouse models.

  2. GM-CSF (show CSF2 Proteins) and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model.

  3. Plau deficiency does not worsen controlled cortical impact-induced brain pathology or epileptogenesis caused by TBI (show TBPL1 Proteins).

  4. we have firstly shown a fundamental mechanism of urokinase system(uPa and uPAR (show PLAUR Proteins))-dependent regulation of the trajectory of growth and branching of blood vessels in early embryogenesis and in adults during the repair/regeneration of tissues.

  5. Pharmacological inhibition of either uPA or selected MMPs decreased atherosclerosis in transgenic uPA mice.

  6. Study shows that the competitive expression or activity of tPA (show PLAT Proteins) and/or PAI-1 (show SERPINE1 Proteins), rather than an altered uPA expression, determines the plasmin (show PLG Proteins)-mediated Abeta (show APP Proteins) proteolysis in brains affected by Alzheimer's disease

  7. Porphyromonas gingivalis-derived RgpA-Kgp complex activates the macrophage uPA.

  8. beta-elemene downregulates expression of uPA, uPAR (show PLAUR Proteins), MMP-2 (show MMP2 Proteins), and MMP-9 (show MMP9 Proteins) in a murine intraocular melanoma model

  9. Data indicate that closed head trauma sequentially releases tissue-type plasminogen activator (tPA (show PLAT Proteins)) followed by delayed synthesis and release of urokinase plasminogen (show PLG Proteins) activator (uPA) from injured brain.

  10. Binding of urokinase to urokinase plasminogen activator receptor (show PLAUR Proteins) promotes dendritic spine recovery and functional outcome after ischemic stroke.

Rabbit Plasminogen Activator, Urokinase (PLAU) interaction partners

  1. uPA-mediated arterial constriction is a vasomotor process that is mediated by uPA catalytic activity, not by the NH(2)-terminal domains.

Cow (Bovine) Plasminogen Activator, Urokinase (PLAU) interaction partners

  1. uPA/uPAR (show PLAUR Proteins) binding is involved in signaling pathways that activate transcription factors that regulate the synthesis of molecules concerned with the arrangement of a particular oviductal microenvironment.

  2. These data indicated that E. coli LPS (show IRF6 Proteins) led to an increase in u-PA activity and RNA expression of u-PA and u-PAR (show PLAUR Proteins) in BME-UV1 cells, thus strengthening the role of the PA system during pathological processes.

  3. The plasminogen/plasminogen (show PLG Proteins) activator/plasmin (show PLG Proteins) system is activated during gamete interaction and regulates the sperm entry into the oocyte.

  4. stage-dependent regulation of granulosa cell PA and SerpinE2 (show SERPINE2 Proteins) production, consistent with a role in extracellular matrix remodeling during follicle growth.

Pig (Porcine) Plasminogen Activator, Urokinase (PLAU) interaction partners

  1. The plasminogen/plasminogen (show PLG Proteins) activator/plasmin (show PLG Proteins) system is activated during gamete interaction and regulates the sperm entry into the oocyte.

PLAU Protein Profile

Protein Summary

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PLAU

  • plasminogen activator, urokinase (PLAU)
  • urokinase-type plasminogen activator (CpipJ_CPIJ002131)
  • urokinase-type plasminogen activator (CpipJ_CPIJ006543)
  • urokinase-type plasminogen activator (CpipJ_CPIJ013396)
  • urokinase-type plasminogen activator (CpipJ_CPIJ013623)
  • plasminogen activator, urokinase (Plau)
  • ATF protein
  • BDPLT5 protein
  • PLAU protein
  • QPD protein
  • u-PA protein
  • uPA protein
  • UPAM protein
  • URK protein

Protein level used designations for PLAU

urokinase-type plasminogen activator , U-plasminogen activator , uPA , plasminogen activator, urokinase , plasminogen activator, urinary , Urinary plasminogen activator, urokinase , urokinase plasminogen activator preproprotein

GENE ID SPECIES
403426 Canis lupus familiaris
100171578 Pongo abelii
100302501 Ovis aries
6032874 Culex quinquefasciatus
6038214 Culex quinquefasciatus
6046380 Culex quinquefasciatus
6047199 Culex quinquefasciatus
5328 Homo sapiens
18792 Mus musculus
25619 Rattus norvegicus
100008633 Oryctolagus cuniculus
281408 Bos taurus
396424 Gallus gallus
396985 Sus scrofa
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