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PLAU Proteins

(Plasminogen Activator, Urokinase (PLAU))

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009].

recommended

PLAU Protein (AA 21-431) (His tag) (ABIN7275455)

PLAU Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

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recommended

PLAU Protein (AA 21-430) (His tag) (ABIN7275453)

PLAU Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

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recommended

PLAU Protein (AA 21-431) (His-Avi Tag,Biotin) (ABIN7275460)

PLAU Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

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PLAU Proteins by Grade

Find PLAU Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

PLAU Proteins by Origin

Find PLAU Proteins for a variety of species such as anti-Human PLAU, anti-Rat PLAU, anti-Chicken PLAU. The species listed below are among those available. Click on a link to go to the corresponding products.

PLAU Proteins by Source

Here you will find PLAU Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

PLAU Proteins by Protein Type

Here you can find PLAU Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

PLAU Proteins by Application

Find PLAU Proteins validated for a specific application such as SDS, WB, ELISA, Imm. Some of the available applications are listed below. Click on a link to go to the corresponding products.

PLAU Proteins by Biological Activity

Find PLAU Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular PLAU Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

PLAU Protein (AA 21-431) (His tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN7275455

Quantity 100 μg

Datasheet Datasheet

PLAU Protein (AA 21-430) (His tag)

Reactivity Cynomolgus

Source HEK-293 Cells

Validations

Cat. No. ABIN7275453

Quantity 100 μg

Datasheet Datasheet

PLAU Protein (AA 21-431) (His-Avi Tag,Biotin)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN7275460

Quantity 100 μg

Datasheet Datasheet

PLAU Protein (AA 179-298) (His-IF2DI Tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7124470

Quantity 50 μg

Datasheet Datasheet

PLAU Protein (AA 16-115) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1315318

Quantity 10 μg

Datasheet Datasheet

PLAU Protein (AA 21-177) (His tag)

Reactivity Human

Source Insect Cells

Validations

Cat. No. ABIN3075302

Quantity 1 mg

Datasheet Datasheet

PLAU Protein (AA 21-431) (His tag)

Reactivity Human

Source Insect Cells

Validations

Cat. No. ABIN3075301

Quantity 1 mg

Datasheet Datasheet

PLAU Protein (AA 179-431) (His tag)

Reactivity Human

Source Insect Cells

Validations

Cat. No. ABIN3075303

Quantity 1 mg

Datasheet Datasheet

PLAU Protein (AA 1-431) (His tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN7505721

Quantity 100 μg

Datasheet Datasheet

PLAU Protein (AA 21-433) (His-Avi Tag)

Reactivity Mouse

Source HEK-293 Cells

Validations

Cat. No. ABIN7454200

Quantity 100 μg

Datasheet Datasheet

PLAU Protein

Reactivity Human

Source Human

Validations

Cat. No. ABIN7508085

Quantity 3 kU

Datasheet Datasheet

PLAU Protein (AA 20-432) (His tag)

Reactivity Rat

Source HEK-293 Cells

Validations

Cat. No. ABIN7504511

Quantity 100 μg

Datasheet Datasheet

PLAU Protein (AA 21-433) (Biotin,His-Avi Tag)

Reactivity Mouse

Source HEK-293 Cells

Validations

Cat. No. ABIN7454201

Quantity 100 μg

Datasheet Datasheet

PLAU Protein (AA 21-431) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7388882

Quantity 100 μg

Datasheet Datasheet

PLAU Protein (His tag)

Reactivity Rabbit

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7388894

Quantity 100 μg

Datasheet Datasheet

Latest Publications for our PLAU Proteins

Ambrosetti, Paoletti, Bosco, Parisse, Scaini, Tagliabue, de Marco, Casalis: "Quantification of Circulating Cancer Biomarkers via Sensitive Topographic Measurements on Single Binder Nanoarrays." in: ACS omega, Vol. 2, Issue 6, pp. 2618-2629, (2017) (PubMed).

Kim, Tirloni, Radulovic, Lewis, Bakshi, Hill, da Silva Vaz, Logullo, Termignoni, Mulenga: "Conserved Amblyomma americanum tick Serpin19, an inhibitor of blood clotting factors Xa and XIa, trypsin and plasmin, has anti-haemostatic functions." in: International journal for parasitology, Vol. 45, Issue 9-10, pp. 613-27, (2015) (PubMed).

Wu, Catano, Echeverry, Torre, Haile, An, Chen, Cheng, Nicholson, Tong, Park, Yepes: "Urokinase-type plasminogen activator promotes dendritic spine recovery and improves neurological outcome following ischemic stroke." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 43, pp. 14219-32, (2014) (PubMed).

Komissarov, Florova, Azghani, Karandashova, Kurdowska, Idell: "Active ?-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 305, Issue 10, pp. L682-92, (2013) (PubMed).

Sanderson-Smith, Zhang, Ly, Donahue, Hollands, Nizet, Ranson, Ploplis, Walker, Castellino: "A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection." in: PLoS pathogens, Vol. 9, Issue 7, pp. e1003469, (2013) (PubMed).

Larusch, Merkulova, Mahdi, Shariat-Madar, Sitrin, Cines, Schmaier: "Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through ?1-integrin and VEGFR2." in: American journal of physiology. Heart and circulatory physiology, Vol. 305, Issue 3, pp. H305-20, (2013) (PubMed).

Ilkovitch, Carrio, Lopez: "uPA and uPA-receptor are involved in cancer-associated myeloid-derived suppressor cell accumulation." in: Anticancer research, Vol. 32, Issue 10, pp. 4263-70, (2012) (PubMed).

Botkjaer, Deryugina, Dupont, Gårdsvoll, Bekes, Thuesen, Chen, Chen, Ploug, Quigley, Andreasen: "Targeting tumor cell invasion and dissemination in vivo by an aptamer that inhibits urokinase-type plasminogen activator through a novel multifunctional mechanism." in: Molecular cancer research : MCR, Vol. 10, Issue 12, pp. 1532-43, (2012) (PubMed).

Novak, Bryer, Cheng, Nguyen, Conley, Cunningham, Xue, Sisson, You, Hornberger, Koh: "Macrophage-specific expression of urokinase-type plasminogen activator promotes skeletal muscle regeneration." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 3, pp. 1448-57, (2011) (PubMed).

Hosseini, Jiang, Sørensen, Jensen, Christensen, Fogh, Yuan, Andersen, Huang, Andreasen, Jensen: "Elucidation of the contribution of active site and exosite interactions to affinity and specificity of peptidylic serine protease inhibitors using non-natural arginine analogs." in: Molecular pharmacology, Vol. 80, Issue 4, pp. 585-97, (2011) (PubMed).

Aliases for PLAU Proteins

plasminogen activator, urokinase (PLAU) Proteins
urokinase-type plasminogen activator (CpipJ_CPIJ002131) Proteins
urokinase-type plasminogen activator (CpipJ_CPIJ006543) Proteins
urokinase-type plasminogen activator (CpipJ_CPIJ013396) Proteins
urokinase-type plasminogen activator (CpipJ_CPIJ013623) Proteins
plasminogen activator, urokinase (Plau) Proteins
ATF Proteins
BDPLT5 Proteins
PLAU Proteins
QPD Proteins
u-PA Proteins
UPA Proteins
uPA Proteins
UPAM Proteins
URK Proteins

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PLAU Proteins by Grade

PLAU Proteins by Origin

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PLAU Proteins by Protein Type

PLAU Proteins by Application

PLAU Proteins by Biological Activity

Popular PLAU Proteins

Latest Publications for our PLAU Proteins

Aliases for PLAU Proteins

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