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PLAU encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. Additionally we are shipping PLAU Antibodies (334) and PLAU Kits (99) and many more products for this protein.
Showing 10 out of 56 products:
Human PLAU Protein expressed in Human - ABIN491612
Reichel, Uhl, Lerchenberger, Puhr-Westerheide, Rehberg, Liebl, Khandoga, Schmalix, Zahler, Deindl, Lorenzl, Declerck, Kanse, Krombach: Urokinase-type plasminogen activator promotes paracellular transmigration of neutrophils via mac-1, but independently of urokinase-type plasminogen activator receptor. in Circulation 2011
Show all 6 references for ABIN491612
Human PLAU Protein expressed in Human Cells - ABIN2003433
Nagai, Hiramatsu, Kanéda, Hayasuke, Arimura, Nishida, Suyama: Molecular cloning of cDNA coding for human preprourokinase. in Gene 1985
Show all 4 references for ABIN2003433
Mouse (Murine) PLAU Protein expressed in Insect Cells - ABIN2544534
Bryer, Fantuzzi, Van Rooijen, Koh: Urokinase-type plasminogen activator plays essential roles in macrophage chemotaxis and skeletal muscle regeneration. in Journal of immunology (Baltimore, Md. : 1950) 2008
Human PLAU Protein expressed in Insect Cells - ABIN491607
Wu, Catano, Echeverry, Torre, Haile, An, Chen, Cheng, Nicholson, Tong, Park, Yepes: Urokinase-type plasminogen activator promotes dendritic spine recovery and improves neurological outcome following ischemic stroke. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
Human PLAU Protein expressed in Human - ABIN491028
Komissarov, Florova, Idell: Effects of extracellular DNA on plasminogen activation and fibrinolysis. in The Journal of biological chemistry 2011
Data suggest that enhanced levels of uPA (show PRAP1 Proteins) in breast cancer modulate the mitogenic effects of EGF (show EGF Proteins) which helps to better understand breast cancer pathogenesis.
Results found high levels of uPA (show PRAP1 Proteins) and uPAR (show PLAUR Proteins) exclusively in metastatic osteosarcoma (OS)cells and suggest that malignant conversion of OS cells to uPA (show PRAP1 Proteins)/uPAR (show PLAUR Proteins) axis in an autocrine and paracrine fashion.
The morphologically normal tissue adjacent to the tumor shows the substantial expression of MMP-2 (show MMP2 Proteins) and MMP-9 (show MMP9 Proteins) and in some cases the enhanced activity of uPA (show PRAP1 Proteins) and ACE (show ACE Proteins), which makes an additional contribution to the increased invasive potential of tumor
Crystal structure of uPA (show PRAP1 Proteins) bound with cyclic peptidic inhibitors.
data on the stromal macrophages immunoreactivity of uPAR (show PLAUR Proteins), MMP-2 (show MMP2 Proteins), and MMP-9 (show MMP9 Proteins) in a few small cell lung cancer (SCLC) and lung squamous cell carcinoma (SCC (show CYP11A1 Proteins)) biopsies was included. uPAR (show PLAUR Proteins), MMP-2 (show MMP2 Proteins), and MMP-9 (show MMP9 Proteins) were confirmed in stromal cells including macrophages
u-PA is a dysregulated gene involved in the tumorigenesis, bio-pathological features and outcomes of EEC.
High cytoplasmic expression of uPA (show PRAP1 Proteins) is associated with cells of rectal cancer and metastases of perienteric lymph nodes.
DIM can influence the cell migratory and invasive properties of human colorectal cancer cells and may decrease the invasive capacity of colorectal cancer through downregulation of uPA (show PRAP1 Proteins) and MMP9 (show MMP9 Proteins) mediated by suppression of the transcription factor FOXM1 (show FOXM1 Proteins)
Porphyromonas gingivalis-derived RgpA-Kgp complex activates the macrophage uPA (show PRAP1 Proteins).
Taking uPA (show PRAP1 Proteins)(1-43) amino acids specifically binding to uPAR (show PLAUR Proteins) as targeted part of fusion protein, and making use of antitumor activity of melittin, the recombinant fusion protein it (show KRT20 Proteins) was able to inhibit growth of ovarian tumors .
GM-CSF (show CSF2 Proteins) and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model.
Plau deficiency does not worsen controlled cortical impact-induced brain pathology or epileptogenesis caused by TBI (show TBPL1 Proteins).
we have firstly shown a fundamental mechanism of urokinase system(uPa and uPAR (show PLAUR Proteins))-dependent regulation of the trajectory of growth and branching of blood vessels in early embryogenesis and in adults during the repair/regeneration of tissues.
Pharmacological inhibition of either uPA or selected MMPs decreased atherosclerosis in transgenic uPA mice.
Study shows that the competitive expression or activity of tPA (show PLAT Proteins) and/or PAI-1 (show SERPINE1 Proteins), rather than an altered uPA expression, determines the plasmin (show PLG Proteins)-mediated Abeta (show APP Proteins) proteolysis in brains affected by Alzheimer's disease
Porphyromonas gingivalis-derived RgpA-Kgp complex activates the macrophage uPA.
beta-elemene downregulates expression of uPA, uPAR (show PLAUR Proteins), MMP-2 (show MMP2 Proteins), and MMP-9 (show MMP9 Proteins) in a murine intraocular melanoma model
Data indicate that closed head trauma sequentially releases tissue-type plasminogen activator (tPA (show PLAT Proteins)) followed by delayed synthesis and release of urokinase plasminogen (show PLG Proteins) activator (uPA) from injured brain.
Binding of urokinase to urokinase plasminogen activator receptor (show PLAUR Proteins) promotes dendritic spine recovery and functional outcome after ischemic stroke.
Protein kinase C-delta (show PKCd Proteins) mediates sepsis-induced activation of complement 5a and urokinase-type plasminogen activator signaling in macrophages
uPA-mediated arterial constriction is a vasomotor process that is mediated by uPA catalytic activity, not by the NH(2)-terminal domains.
uPA/uPAR (show PLAUR Proteins) binding is involved in signaling pathways that activate transcription factors that regulate the synthesis of molecules concerned with the arrangement of a particular oviductal microenvironment.
These data indicated that E. coli LPS (show IRF6 Proteins) led to an increase in u-PA activity and RNA expression of u-PA and u-PAR (show PLAUR Proteins) in BME-UV1 cells, thus strengthening the role of the PA system during pathological processes.
The plasminogen/plasminogen (show PLG Proteins) activator/plasmin (show PLG Proteins) system is activated during gamete interaction and regulates the sperm entry into the oocyte.
stage-dependent regulation of granulosa cell PA and SerpinE2 (show SERPINE2 Proteins) production, consistent with a role in extracellular matrix remodeling during follicle growth.
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
urokinase-type plasminogen activator
, U-plasminogen activator
, plasminogen activator, urokinase
, plasminogen activator, urinary
, Urinary plasminogen activator, urokinase
, urokinase plasminogen activator preproprotein