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Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. Additionally we are shipping Plastin 3 Antibodies (56) and many more products for this protein.
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PLS3 is a genuine spinal muscular atrophy protective modifier in SMN1 (show SMN1 Proteins)-deleted individuals
Measurements of SMN (show STMN1 Proteins) and PLS3 transcript and protein levels in induced pluripotent stem cell-derived motor neurons show limited value as Spinal muscular atrophy biomarkers.
High levels of recombinant hPLS3 mRNA were expressed in motor neurons of SMA (show SMN1 Proteins) mice and an increased level of PLS3 protein in total spinal cord, yet neither survival nor the fundamental electrophysiological aspects of the neuromuscular junction improved.
results confirm the role of PLS3 mutations in early onset osteoporosis. The mechanism whereby PLS3 affects bone health is unclear, but it may be linked to osteocyte dendrite function and skeletal mechanosensing
plastin 3 is a regulator of actin microfilament bundles at the ES in which it dictates the configuration of the filamentous actin network
PLS3 was expressed in circulating tumor cells undergoing the epithelial-mesenchymal transition in patients with breast cancer; an excellent biomarker for identifying groups at risk of recurrence or with a poor prognosis
PLS3 overexpression is associated with colorectal cancer.
T-plastin expression downstream to the calcineurin (show PPP3CA Proteins)/NFAT (show NFATC1 Proteins) pathway is involved in keratinocyte migration.
Data suggest that several single-nucleotide polymorphisms (SNPs) of the plastin genes PLS3 and LCP1 (show LCP1 Proteins) could serve as gender- and/or stage-specific molecular predictors of tumor recurrence in stage II/III colorectal cancer as well as therapeutic targets.
Loss of PLS3 is associated with spinal muscular atrophy.
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.
, plastin 3 (T isoform)
, T fimbrin
, T plastin
, plastin 3 (T-isoform)
, plastin 3, T