Plastin 3 Proteins (PLS3)

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. Additionally we are shipping Plastin 3 Antibodies (61) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PLS3 5358 P13797
PLS3 81748  
PLS3 102866 Q99K51
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Top Plastin 3 Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$730.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$768.00
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 20 to 21 Days
$437.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,822.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$935.00
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$976.25
Details

PLS3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Rat (Rattus)

Mouse (Murine) ,

More Proteins for Plastin 3 (PLS3) Interaction Partners

Human Plastin 3 (PLS3) interaction partners

  1. PLS3 mutation plays a role in low turnover osteoporosis pathophysiology.

  2. In this study, the authors found that the actin filament bundling abilities of PLS1 (show PLS1 Proteins) and PLS2 (show LCP1 Proteins) were similarly sensitive to Ca(2 (show CA2 Proteins)+) (pCa50 ~6.4), whereas PLS3 was less sensitive (pCa50 ~5.9).

  3. Patients with PLS3 mutation-related osteoporosis respond to teriparatide treatment.

  4. We show that genes of the classical apoptosis pathway are involved in the smn-1 (show SMN1 Proteins)-mediated neuronal death, and that this phenotype can be rescued by the expression of human SMN1 (show SMN1 Proteins), indicating a functional conservation between the two orthologs. Finally, we determined that Plastin3/plst-1 genetically interacts with smn-1 (show SMN1 Proteins) to prevent degeneration, and that treatment with valproic acid is able to rescue the degenerative phenotype

  5. PLS3 expression does not always modify SMA (show SMN1 Proteins) phenotype

  6. findings emphasize the power of genetic modifiers, PLS3 and CORO1C (show CORO1C Proteins), to unravel the cellular pathomechanisms underlying spinal muscular atrophy (SMA (show SMN1 Proteins))--and the power of combinatorial therapy based on splice correction of SMN2 (show SMN1 Proteins) and endocytosis improvement to efficiently treat SMA (show SMN1 Proteins)

  7. PLS3 is a genuine spinal muscular atrophy protective modifier in SMN1 (show SMN1 Proteins)-deleted individuals

  8. Measurements of SMN (show STMN1 Proteins) and PLS3 transcript and protein levels in induced pluripotent stem cell-derived motor neurons show limited value as Spinal muscular atrophy biomarkers.

  9. High levels of recombinant hPLS3 mRNA were expressed in motor neurons of SMA (show SMN1 Proteins) mice and an increased level of PLS3 protein in total spinal cord, yet neither survival nor the fundamental electrophysiological aspects of the neuromuscular junction improved.

  10. results confirm the role of PLS3 mutations in early onset osteoporosis. The mechanism whereby PLS3 affects bone health is unclear, but it may be linked to osteocyte dendrite function and skeletal mechanosensing

Plastin 3 (PLS3) Protein Profile

Protein Summary

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with Plastin 3 Proteins (PLS3)

  • plastin 3 (pls3)
  • plastin 3 (PLS3)
  • plastin 3 (T isoform) (pls3)
  • plastin 3 (Pls3)
  • plastin 3 (T-isoform) (Pls3)
  • T-plastin (LOC100689375)
  • AI115446 protein
  • AL024105 protein
  • DKFZp459D0939 protein
  • MGC68681 protein
  • MGC106020 protein
  • Plastin-3 protein
  • PLS3 protein
  • T-fimbrin protein
  • T-plastin protein

Protein level used designations for Plastin 3 Proteins (PLS3)

plastin 3 , plastin 3 (T isoform) , plastin-3 , plastin-3-like , T fimbrin , T plastin , T-plastin , plastin 3 (T-isoform) , plastin 3, T

GENE ID SPECIES
399002 Xenopus laevis
465817 Pan troglodytes
481025 Canis lupus familiaris
595091 Xenopus (Silurana) tropicalis
709055 Macaca mulatta
100053927 Equus caballus
100158187 Sus scrofa
100172754 Pongo abelii
100403677 Callithrix jacchus
100475279 Ailuropoda melanoleuca
100545275 Meleagris gallopavo
100602943 Nomascus leucogenys
5358 Homo sapiens
81748 Rattus norvegicus
505687 Bos taurus
102866 Mus musculus
100689375 Cricetulus griseus
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