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PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation (Nanda et al., 2005 [PubMed 15851471]).[supplied by OMIM, Mar 2008].. Additionally we are shipping PEAR1 Antibodies (46) and PEAR1 Kits (3) and many more products for this protein.
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PEAR1 genetic variations were strongly associated with platelet reactivity in a Chinese patient population with coronary heart disease undergoing dual antiplatelet therapy with aspirin and clopidogrel.
A considerable portion of Chinese ischemic stroke patients are insensitive to aspirin treatment, which may be correlated with the MDR1 C3435T, TBXA2R (show TBXA2R Proteins) (rs1131882), and PLA2G7 (show Lp-PLA2 Proteins) (rs1051931-rs7756935) polymorphisms.
Platelet endothelial aggregation receptor-1: a novel modifier of neoangiogenesis.
Results suggest that genetic variation of PEAR1 is a significant determinant of endothelial function through pathways implicated in cardiovascular disease.
FcepsilonRI (show FCER1G Proteins) alpha-chain (show FCGRT Proteins) is an activating platelet endothelium aggregation receptor 1 (PEAR1) ligand.
genetic variability of GAS6 (show GAS6 Proteins) and PEAR1 genes may be associated with platelet hyperaggregability
A common genetic variant in PEAR1 (rs12041331) reproducibly influenced platelet aggregation in aspirin-treated patients with coronary artery disease.
study suggests that PEAR1 is not a hypertension susceptibility gene in humans.
The SNPs in two regions of the PEAR1 gene, from rs3737224 to rs822442, and from rs1214331 to rs12566888, probably play important roles in prasugrel pharmacodynamics
additional exonic variants in PEAR1 that may also determine variability in platelet aggregation, were identified.
Jedi-1 signals through recruitment of GULP (show GULP1 Proteins), which promotes phagocytosis through a noncanonical phosphoclathrin-dependent mechanism.
These results indicated that both Jedi-1 and MEGF10 (show MEGF10 Proteins) can mediate phagocytosis independently through the recruitment of Syk (show SYK Proteins).
Jedi is involved in the fine regulation of the early stages of hematopoietic differentiation, presumably through the Notch (show NOTCH1 Proteins) signaling pathway.
a cellular and molecular mechanism by which neuronal corpses are culled during dorsal root ganglia development involves Jedi protein
PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation (Nanda et al., 2005
platelet endothelial aggregation receptor 1
, multiple EGF-like-domains 12
, platelet endothelial aggregation receptor 1-like
, multiple EGF-like domains protein 12
, multiple epidermal growth factor-like domains protein 12
, jagged and Delta protein
, protein Jedi