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PTAFR encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. Additionally we are shipping PTAFR Kits (27) and PTAFR Proteins (3) and many more products for this protein.
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PAFR is overexpressed in NSCLC as well as in breast, colorectal, and gastric carcinomas. PAFR expression correlates with clinical stages, survival time, and distant metastasis. PAF (show KIAA0101 Antibodies)/PAFR signaling also upregulated IL6 (show IL6 Antibodies) expression and STAT3 (show STAT3 Antibodies) activation.
we made the first demonstration that dysregulation of PAFR and the positive regulatory loop between PAFR and pAKT (show AKT1 Antibodies) contribute to malignant progression of esophageal squamous cell carcinoma
Data support an important role for PAFR in tumor growth and suggest that engagement of PAFR interferes with selected pathways in macrophages, changing their phenotype into that of a regulatory with suppressor activities. [review]
Epithelial PAFr expression is upregulated in smokers, especially in those with COPD (show ARCN1 Antibodies), and is not obviously affected by inhaled corticosteroid therapy.
Results suggest that WEB2086 and AG1478 are synergistic in ovarian cancer cells with high expression of both platelet-activating factor receptor (PAFR) and epidermal growth factor receptor (EGFR (show EGFR Antibodies)).
PAFR may have an important role in modulating the cisplatin sensitivity of ovarian cancer cells.
patients presenting elevated PAFR expression had significantly longer survival times compared to those with low PAFR expression (log-rank test, p<0.001).
oxLDL induces the recruitment of PAFR and CD36 (show CD36 Antibodies) into the same lipid rafts, which is important for oxLDL uptake and IL-10 (show IL10 Antibodies) production
Data suggest PAF/PAF (show KIAA0101 Antibodies) receptor signaling exerts proinflammatory effect on neutrophil via down-regulation of LXRa (liver X receptor alpha (show NR1H3 Antibodies)) and target genes (ATP-binding cassette transporter (show ABCA4 Antibodies) (ABC (show ABCB6 Antibodies)) A1, ABC (show ABCB6 Antibodies) G1, sterol response element binding protein 1c).
Inhibition of platelet aggregation by lipoteichoic acid was blocked using a monoclonal anti-PafR antibody and Ginkgolide B,a well-defined PafR antagonist, demonstrating that the LTA (show LTA Antibodies) inhibitory signal occurs via PafR.
In the absence of PAFR signalling, monocytes and macrophages acquire a pro-inflammatory phenotype, resulting in adipose tissue inflammation and metabolic dysfunction.
Data (including data from studies in knockout mice) suggest that signal transduction via platelet-activating factor (PAF (show KIAA0101 Antibodies)) and PAF receptor is involved in regulation of lipid metabolism/inflammation in liver of mice on high-refined carbohydrate diet.
ExoU activates NF-kappaB (show NFKB1 Antibodies) by PAFR signalling, which in turns enhances PAFR expression, highlighting an important mechanism of amplification of response to this P. aeruginosa toxin.
In PAF receptor-knockout mice, diet-induced obesity is exacerbated.
Bacteria did not associate with PAFR, indicating an indirect role of PAFR in pneumococcal adhesion to endothelial cells.
PAFR deficiency resulted in less inflammation in adipose tissue and improvement in glucose homeostasis in mice fed a high-carbohydrate diet
PAFR and CD36 (show CD36 Antibodies) coimmunoprecipitated with flotillin-1 (show FLOT1 Antibodies), a constitutive lipid raft protein, and disruption of these membrane microdomains by methyl-beta-cyclodextrin reduced apoptotic cells phagocytosis
Our findings establish the existence of a functional partnership PAF-R/eNOS (show NOS3 Antibodies) on endothelial cell plasma membrane.
Activation of PAF-receptor induces regulatory dendritic cells through PGE2 and IL-10 (show IL10 Antibodies).
PAFR signaling contributes to a pro-inflammatory environment in the model of obstructive nephropathy, favoring the fibrotic process.
The gene expression of PAFR was upregulated, as an effect of light exposure, in the third eyelid but not in the cornea.
PAF (show KIAA0101 Antibodies) and luteinizing hormone signaling plays an important role in regulating the production of excessive oxidants.
The results provide clear evidence for expression of PAFr in bovine granulosa cells and its functional involvement in PAF (show KIAA0101 Antibodies)/PAFr-mediated stimulation of cell recruitment.
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.
platelet-activating factor receptor
, PAF receptor