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May help orchestrate cytoskeletal arrangement. Additionally we are shipping Pleckstrin 2 Antibodies (12) and many more products for this protein.
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expression of PLEK2, the strongest gene to classify melanoma patients, in CD45 (show PTPRC Proteins)(-) subsets illustrates the importance of analyzing whole blood cells for biomarker studies
Pleckstrin 2 was cloned; its mRNA is widely expressed in a variety of cell lines.
pleckstrin-2 uses its modular domains to bind to membrane-associated phosphatidylinositols generated by PI3K, whereby it coordinates with the actin cytoskeleton in lymphocyte spreading and immune synapse formation.
These results suggest that PLEK2 is involved in actin rearrangement in a PI 3 (show PI3 Proteins)-kinase dependent manner.
our study identified a dual function of pleckstrin-2 in the early and late stages of terminal erythropoiesis through its regulations of actin dynamics and cofilin's mitochondrial localization.
May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation.
, pleckstrin 2 homolog