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Involved in TGN-to-plasma membrane transport and in the formation of post-Golgi constitutive carriers. Additionally we are shipping Pleckstrin Homology Domain Containing, Family A (Phosphoinositide Binding Specific) Member 8 Proteins (3) and many more products for this protein.
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Human Polyclonal PLEKHA8 Primary Antibody for IHC (p) - ABIN374369
Dowler, Currie, Campbell, Deak, Kular, Downes, Alessi: Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. in The Biochemical journal 2001
Altogether, this study implies that hepatitis C virus coopts FAPP2 for virus genome replication via phosphatidylinositol 4-phosphate binding and glycosphingolipid transport to the hepatitis C virus replication complex.
FAPP2 functions in both membrane trafficking and lipid metabolism in a fashion that integrates its activities in membrane trafficking and in lipid transfer. (Review)
Data demonstrate FAPP2 is required for cilium formation in polarized MDCK cells.
Data show that FAPP2 is present in tubules forming from the trans-Golgi in epithelial MDCK cells.
Data show that FAPP1 (show PLEKHA3 Antibodies) and 2 are essential components of a phosphatidylinositol 4-phosphate- and ADP-ribosylation factor (show ARF1 Antibodies)-regulated machinery that controls generation of constitutive post-Golgi carriers.
FAPP2 plays a specific role in apical transport in MDCK cells.
by coupling the synthesis of glycosphingolipids with their export to the cell surface, FAPP2 emerges as crucial in determining the lipid identity and composition of the plasma membrane
These data demonstrate a previously unknown role for FAPP2 in conferring resistance to apoptosis and indicate that FAPP2 may be a target for cancer therapy.
Involved in TGN-to-plasma membrane transport and in the formation of post-Golgi constitutive carriers. May play a role in ensuring the coordination of the budding and the fission reactions (By similarity).
PH domain-containing family A member 8
, phosphatidylinositol-four-phosphate adapter protein 2
, phosphoinositol 4-phosphate adapter protein 2
, pleckstrin homology domain-containing family A member 8
, pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
, pleckstrin homology domain-containing family A member 8-like
, serologically defined breast cancer antigen NY-BR-86