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Pleckstrin Homology Domain Containing, Family A (phosphoinositide Binding Specific) Member 1 (PLEKHA1) ELISA Kits

PLEKHA1 encodes a pleckstrin homology domain-containing adapter protein. Additionally we are shipping PLEKHA1 Antibodies (42) and PLEKHA1 Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Rat PLEKHA1 PLEKHA1 361659  
Anti-Human PLEKHA1 PLEKHA1 59338 Q9HB21
Anti-Mouse PLEKHA1 PLEKHA1 101476 Q8BUL6
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More ELISA Kits for PLEKHA1 Interaction Partners

Human Pleckstrin Homology Domain Containing, Family A (phosphoinositide Binding Specific) Member 1 (PLEKHA1) interaction partners

  1. Studies indicate that the high-risk allele of the 10q26 locus encompasses three genes, PLEKHA1, ARMS2 (show ARMS2 ELISA Kits), and HTRA1 (show HTRA1 ELISA Kits) with high linkage disequilibrium.

  2. CX3CR1 (show CX3CR1 ELISA Kits) (T280M and V249I) and PLEKHA1 (A320T) polymorphisms were not found to be associated with age-related macular degeneration in an Indian population.

  3. This study provides evidence of the joint contribution of genetic variants in PLEKHA1/ARMS2 (show ARMS2 ELISA Kits)/HTRA1 (show HTRA1 ELISA Kits) to age-related macular degeneration risk.

  4. TAPP1 binds to protein tyrosine phosphatase PTPL1 (show PTPN13 ELISA Kits).

  5. syntrophins regulate the localization of TAPP1, which may be important for remodeling the actin cytoskeleton in response to growth factor stimulation

  6. PLEKHA1 is strongly implicated as primarily responsible for the evidence of linkage of age-related maculopathy (ARM) to the 10q26 locus and as a major contributor to ARM.susceptibility.

  7. Although a role for PLEKHA1 could not be totally excluded, there was a four times higher age-related macular degeneration risk was associated with haplotype "A-T-A" involving "PLEKHA1-LOC387715-HTRA1 (show HTRA1 ELISA Kits)" risk alleles.

  8. Independent of CFH (show CFH ELISA Kits) genotype or smoking history, an individual's risk of AMD (show AMD1 ELISA Kits) (age-related macular degeneration) could be increased or decreased, depending on their genotype or haplotype in the 10q26 region.

Mouse (Murine) Pleckstrin Homology Domain Containing, Family A (phosphoinositide Binding Specific) Member 1 (PLEKHA1) interaction partners

  1. Results identify TAPP1 as an important negative regulator of oligodendrocyte precursor cells differentiation through the Mek (show MDK ELISA Kits)/Erk (show EPHB2 ELISA Kits) signaling pathway.

  2. interacts with phosphatidylinositol (3,4)-bisphosphate thus regulating B-cell activation (show BLNK ELISA Kits) and autoantibody production

PLEKHA1 Antigen Profile

Antigen Summary

This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.

Gene names and symbols associated with PLEKHA1

  • pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 (Plekha1) antibody
  • pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 (plekha1) antibody
  • pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 (PLEKHA1) antibody
  • AA960558 antibody
  • C920009D07Rik antibody
  • DKFZp459M1025 antibody
  • fc34a05 antibody
  • fc57h12 antibody
  • MGC83674 antibody
  • PLEKHA1 antibody
  • RGD1564153 antibody
  • TAPP1 antibody
  • wu:fc34a05 antibody
  • wu:fc57h12 antibody
  • zgc:55676 antibody

Protein level used designations for PLEKHA1

pleckstrin homology domain-containing family A member 1 , pleckstrin homology domain-containing protein family A member 1 , tandem PH domain containing protein-1 , pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 , tandem PH domain-containing protein 1 , PH domain-containing family A member 1 , TAPP-1

GENE ID SPECIES
361659 Rattus norvegicus
406745 Danio rerio
423940 Gallus gallus
446375 Xenopus laevis
450790 Pan troglodytes
477851 Canis lupus familiaris
513040 Bos taurus
549587 Xenopus (Silurana) tropicalis
100019790 Monodelphis domestica
100058481 Equus caballus
100174594 Pongo abelii
59338 Homo sapiens
101476 Mus musculus
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