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Pleckstrin Homology Domain Containing, Family A (phosphoinositide Binding Specific) Member 1 Proteins (PLEKHA1)

PLEKHA1 encodes a pleckstrin homology domain-containing adapter protein. Additionally we are shipping PLEKHA1 Antibodies (39) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat PLEKHA1 PLEKHA1 361659  
PLEKHA1 59338 Q9HB21
PLEKHA1 101476 Q8BUL6
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Top PLEKHA1 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$806.30
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$983.48
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PLEKHA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Pleckstrin Homology Domain Containing, Family A (phosphoinositide Binding Specific) Member 1 (PLEKHA1) Interaction Partners

Human Pleckstrin Homology Domain Containing, Family A (phosphoinositide Binding Specific) Member 1 (PLEKHA1) interaction partners

  1. Studies indicate that the high-risk allele of the 10q26 locus encompasses three genes, PLEKHA1, ARMS2 (show ARMS2 Proteins), and HTRA1 (show HTRA1 Proteins) with high linkage disequilibrium.

  2. CX3CR1 (show CX3CR1 Proteins) (T280M and V249I) and PLEKHA1 (A320T) polymorphisms were not found to be associated with age-related macular degeneration in an Indian population.

  3. This study provides evidence of the joint contribution of genetic variants in PLEKHA1/ARMS2 (show ARMS2 Proteins)/HTRA1 (show HTRA1 Proteins) to age-related macular degeneration risk.

  4. TAPP1 binds to protein tyrosine phosphatase PTPL1 (show PTPN13 Proteins).

  5. syntrophins regulate the localization of TAPP1, which may be important for remodeling the actin cytoskeleton in response to growth factor stimulation

  6. PLEKHA1 is strongly implicated as primarily responsible for the evidence of linkage of age-related maculopathy (ARM) to the 10q26 locus and as a major contributor to ARM.susceptibility.

  7. Although a role for PLEKHA1 could not be totally excluded, there was a four times higher age-related macular degeneration risk was associated with haplotype "A-T-A" involving "PLEKHA1-LOC387715-HTRA1 (show HTRA1 Proteins)" risk alleles.

  8. Independent of CFH (show CFH Proteins) genotype or smoking history, an individual's risk of AMD (show AMD1 Proteins) (age-related macular degeneration) could be increased or decreased, depending on their genotype or haplotype in the 10q26 region.

Mouse (Murine) Pleckstrin Homology Domain Containing, Family A (phosphoinositide Binding Specific) Member 1 (PLEKHA1) interaction partners

  1. Results identify TAPP1 as an important negative regulator of oligodendrocyte precursor cells differentiation through the Mek (show MDK Proteins)/Erk (show EPHB2 Proteins) signaling pathway.

  2. interacts with phosphatidylinositol (3,4)-bisphosphate thus regulating B-cell activation (show BLNK Proteins) and autoantibody production

PLEKHA1 Protein Profile

Protein Summary

This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.

Gene names and symbols associated with PLEKHA1

  • pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 (Plekha1)
  • pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 (plekha1)
  • pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 (PLEKHA1)
  • AA960558 protein
  • C920009D07Rik protein
  • DKFZp459M1025 protein
  • fc34a05 protein
  • fc57h12 protein
  • MGC83674 protein
  • PLEKHA1 protein
  • RGD1564153 protein
  • TAPP1 protein
  • wu:fc34a05 protein
  • wu:fc57h12 protein
  • zgc:55676 protein

Protein level used designations for PLEKHA1

pleckstrin homology domain-containing family A member 1 , pleckstrin homology domain-containing protein family A member 1 , tandem PH domain containing protein-1 , pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 , tandem PH domain-containing protein 1 , PH domain-containing family A member 1 , TAPP-1

GENE ID SPECIES
361659 Rattus norvegicus
406745 Danio rerio
423940 Gallus gallus
446375 Xenopus laevis
450790 Pan troglodytes
477851 Canis lupus familiaris
513040 Bos taurus
549587 Xenopus (Silurana) tropicalis
100019790 Monodelphis domestica
100058481 Equus caballus
100174594 Pongo abelii
59338 Homo sapiens
101476 Mus musculus
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