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May be a transforming oncogene with exchange activity for CDC42. Additionally we are shipping PLEKHG2 Antibodies (11) and many more products for this protein.
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Role of PLEKHG2 in actin polymerization and clinical and radiological findings in PLEKHG2 deficiency.
Autoantibodies binding to Plekhg2 were found in 19 of 29 patients (66%) with active mycobacterial infections.
The tyrosine phosphorylation of PLEKHG2 plays an important role in EphB2 (show EPHB2 Proteins) signaling, which is closely related to cell growth and the proliferation of tumor.
results provide evidence that stimulation of the Ras/MAPK (show MAPK1 Proteins) pathway by EGFR (show EGFR Proteins) results in FLJ00018 phosphorylation at Thr (show TRH Proteins)-680, which in turn controls changes in cell shape.
PLEKHG2 may serve as a key Gbeta-gamma-stimulated RhoGEF that regulates lymphocyte chemotaxis via Rac and Cdc42 activation and actin polymerization.
These results suggest that FLJ00018 is targeted via its pleckstrin (show PLEK Proteins) homology domain to cellular membranes.
The binding of Rho family specific guanine nucleotide exchange factor(FLJ00018), at least two actin binding regions of FLJ00018, and actin negatively regulates for FLJ00018 function.
Activation of clg (show MMP1 Proteins), a novel dbl (show MCF2 Proteins) family guanine nucleotide exchange factor (show RASGRF1 Proteins) gene, by proviral insertion at evi24, a common integration site in B cell and myeloid leukemias
signaling pathway by which G(i)-coupled receptor specifically induces Rac (show AKT1 Proteins) and Cdc42 (show CDC42 Proteins) activation through direct interaction of Gbetagamma with FLJ00018.
May be a transforming oncogene with exchange activity for CDC42. May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (By similarity).
PH domain-containing family G member 2
, common-site lymphoma/leukemia guanine nucleotide exchange factor
, pleckstrin homology domain-containing family G member 2
, common site lymphoma/leukemia GEF
, common site lymphoma/leukemia guanine nucleotide exchange factor
, common-site lymphoma/leukemia GEF