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anti-Pleckstrin Homology Domain Containing, Family M (With RUN Domain) Member 1 (PLEKHM1) Antibodies

The protein encoded by PLEKHM1 is essential for bone resorption, and may play a critical role in vesicular transport in the osteoclast. Additionally we are shipping PLEKHM1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PLEKHM1 9842 Q9Y4G2
PLEKHM1 353047 Q7TSI1
PLEKHM1 303584 Q5PQS0
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Top anti-PLEKHM1 Antibodies at antibodies-online.com

Showing 10 out of 44 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of PLEKHM1 Antibody (N-term) in K562 cell line lysates (35ug/lane). This demonstrates the PLEKHM1 antibody detected the PLEKHM1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of PLEKHM1 in human lung tissue with this product at 5 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated WB PLEKHM1 Antibody (N-term) (ABIN656973) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the PLEKHM1 antibody detected the PLEKHM1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged PLEKHM1 is approximately 1 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 100 μg Log in to see 8 to 10 Days
$522.50
Details
Human Rabbit Alkaline Phosphatase (AP) ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged PLEKHM1 is approximately 1ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

PLEKHM1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-PLEKHM1 Antibodies

  1. Human Polyclonal PLEKHM1 Primary Antibody for EIA, WB - ABIN954203 : Edwards, Scott, Almonte, Burt, Powell, Beecham, Wang, Züchner, Konidari, Wang, Singer, Nahab, Scott, Stajich, Pericak-Vance, Haines, Vance, Martin: Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. in Annals of human genetics 2010 (PubMed)
    Show all 3 references for ABIN954203

  2. Human Polyclonal PLEKHM1 Primary Antibody for EIA, IHC (p) - ABIN500509 : van Wesenbeeck, Odgren, Mackay, Van Hul: Localization of the gene causing the osteopetrotic phenotype in the incisors absent (ia) rat on chromosome 10q32.1. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004 (PubMed)
    Show all 3 references for ABIN500509

More Antibodies against PLEKHM1 Interaction Partners

Human Pleckstrin Homology Domain Containing, Family M (With RUN Domain) Member 1 (PLEKHM1) interaction partners

  1. identified PLEKHM1 as an endolysosomal adaptor platform that acts as a central hub to integrate endocytic and autophagic pathways at the lysosome

  2. Authors show that Pleckstrin (show PLEK Antibodies) homology domain-containing protein family member 1 (PLEKHM1), a lysosomal adaptor, is targeted by Salmonella through direct interaction with SifA.

  3. PLEKHM1 regulates autophagosome-lysosome fusion through homotypic fusion and protein sorting complex and LC3 (show MAP1LC3A Antibodies)/GABARAP (show GABARAP Antibodies) proteins.

  4. Rubicon (show KIAA0226 Antibodies) and PLEKHM1 specifically and directly interact with Rab7 (show RAB7B Antibodies) via their RH domain; this interaction is critical for their function; show Rubicon (show KIAA0226 Antibodies) but not PLEKHM1 uniquely regulates membrane trafficking via simultaneously binding both Rab7 (show RAB7B Antibodies) and PI3-kinase (show PIK3CA Antibodies)

  5. These data indicate that B2 is a novel, ubiquitously expressed protein with a putative adapter function. The protein has been named AP162.

  6. PLEKHM1 is a novel gene implicated in the development of osteopetrosis (show CSF1 Antibodies), with a putative critical function in vesicular transport in the osteoclast.

  7. heterozygous mutation (R714C) of the osteopetrosis (show CSF1 Antibodies) gene, pleckstrin (show PLEK Antibodies) homolog domain containing family M (with run domain) member 1 (PLEKHM1), impairs vesicular acidification and increases TRACP (show ACP5 Antibodies) secretion in osteoclasts

Mouse (Murine) Pleckstrin Homology Domain Containing, Family M (With RUN Domain) Member 1 (PLEKHM1) interaction partners

  1. TRAFD1 (show TRAFD1 Antibodies), in association with Plekhm1/Rab7 (show RAB7A Antibodies)-positive late endosomes-early lysosomes, has a previously unknown role in vesicle trafficking, acidification, and resorption in osteoclasts

  2. identified PLEKHM1 as an endolysosomal adaptor platform that acts as a central hub to integrate endocytic and autophagic pathways at the lysosome

  3. results indicate that LIS1 (show PAFAH1B1 Antibodies) is a previously unrecognized regulator of osteoclast formation, microtubule organization, and lysosomal secretion by virtue of its ability to modulate dynein function and Plekhm1

PLEKHM1 Antigen Profile

Protein Summary

The protein encoded by this gene is essential for bone resorption, and may play a critical role in vesicular transport in the osteoclast. Mutations in this gene are associated with autosomal recessive osteopetrosis type 6 (OPTB6). Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with PLEKHM1

  • pleckstrin homology domain containing, family M (with RUN domain) member 1 (PLEKHM1) antibody
  • pleckstrin homology domain containing, family M (with RUN domain) member 1 (Plekhm1) antibody
  • AP162 antibody
  • B2 antibody
  • BC038943 antibody
  • D330036J23Rik antibody
  • OPTB6 antibody

Protein level used designations for PLEKHM1

pleckstrin homology domain containing, family M (with RUN domain) member 1 , 162 kDa adapter protein , PH domain-containing family M member 1 , pleckstrin homology domain-containing family M member 1

GENE ID SPECIES
454754 Pan troglodytes
490925 Canis lupus familiaris
9842 Homo sapiens
353047 Mus musculus
303584 Rattus norvegicus
100523462 Sus scrofa
Selected quality suppliers for anti-PLEKHM1 (PLEKHM1) Antibodies
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