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Pleckstrin Homology Domain Containing, Family M (With RUN Domain) Member 1 (PLEKHM1) ELISA Kits

The protein encoded by PLEKHM1 is essential for bone resorption, and may play a critical role in vesicular transport in the osteoclast. Additionally we are shipping PLEKHM1 Antibodies (44) and PLEKHM1 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human PLEKHM1 PLEKHM1 9842 Q9Y4G2
Anti-Mouse PLEKHM1 PLEKHM1 353047 Q7TSI1
Anti-Rat PLEKHM1 PLEKHM1 303584 Q5PQS0
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More ELISA Kits for PLEKHM1 Interaction Partners

Human Pleckstrin Homology Domain Containing, Family M (With RUN Domain) Member 1 (PLEKHM1) interaction partners

  1. identified PLEKHM1 as an endolysosomal adaptor platform that acts as a central hub to integrate endocytic and autophagic pathways at the lysosome

  2. Authors show that Pleckstrin (show PLEK ELISA Kits) homology domain-containing protein family member 1 (PLEKHM1), a lysosomal adaptor, is targeted by Salmonella through direct interaction with SifA.

  3. PLEKHM1 regulates autophagosome-lysosome fusion through homotypic fusion and protein sorting complex and LC3 (show MAP1LC3A ELISA Kits)/GABARAP (show GABARAP ELISA Kits) proteins.

  4. Rubicon and PLEKHM1 specifically and directly interact with Rab7 (show RAB7B ELISA Kits) via their RH domain; this interaction is critical for their function; show Rubicon but not PLEKHM1 uniquely regulates membrane trafficking via simultaneously binding both Rab7 (show RAB7B ELISA Kits) and PI3-kinase (show PIK3CA ELISA Kits)

  5. These data indicate that B2 is a novel, ubiquitously expressed protein with a putative adapter function. The protein has been named AP162.

  6. PLEKHM1 is a novel gene implicated in the development of osteopetrosis (show CSF1 ELISA Kits), with a putative critical function in vesicular transport in the osteoclast.

  7. heterozygous mutation (R714C) of the osteopetrosis (show CSF1 ELISA Kits) gene, pleckstrin (show PLEK ELISA Kits) homolog domain containing family M (with run domain) member 1 (PLEKHM1), impairs vesicular acidification and increases TRACP (show ACP5 ELISA Kits) secretion in osteoclasts

Mouse (Murine) Pleckstrin Homology Domain Containing, Family M (With RUN Domain) Member 1 (PLEKHM1) interaction partners

  1. TRAFD1 (show TRAFD1 ELISA Kits), in association with Plekhm1/Rab7 (show RAB7A ELISA Kits)-positive late endosomes-early lysosomes, has a previously unknown role in vesicle trafficking, acidification, and resorption in osteoclasts

  2. identified PLEKHM1 as an endolysosomal adaptor platform that acts as a central hub to integrate endocytic and autophagic pathways at the lysosome

  3. results indicate that LIS1 (show PAFAH1B1 ELISA Kits) is a previously unrecognized regulator of osteoclast formation, microtubule organization, and lysosomal secretion by virtue of its ability to modulate dynein function and Plekhm1

PLEKHM1 Antigen Profile

Antigen Summary

The protein encoded by this gene is essential for bone resorption, and may play a critical role in vesicular transport in the osteoclast. Mutations in this gene are associated with autosomal recessive osteopetrosis type 6 (OPTB6). Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with PLEKHM1

  • pleckstrin homology domain containing, family M (with RUN domain) member 1 (PLEKHM1) antibody
  • pleckstrin homology domain containing, family M (with RUN domain) member 1 (Plekhm1) antibody
  • AP162 antibody
  • B2 antibody
  • BC038943 antibody
  • D330036J23Rik antibody
  • OPTB6 antibody

Protein level used designations for PLEKHM1

pleckstrin homology domain containing, family M (with RUN domain) member 1 , 162 kDa adapter protein , PH domain-containing family M member 1 , pleckstrin homology domain-containing family M member 1

GENE ID SPECIES
454754 Pan troglodytes
490925 Canis lupus familiaris
9842 Homo sapiens
353047 Mus musculus
303584 Rattus norvegicus
100523462 Sus scrofa
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