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Pleckstrin Homology Domain Containing, Family M (With RUN Domain) Member 1 Proteins (PLEKHM1)

The protein encoded by PLEKHM1 is essential for bone resorption, and may play a critical role in vesicular transport in the osteoclast. Additionally we are shipping PLEKHM1 Antibodies (44) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PLEKHM1 9842 Q9Y4G2
PLEKHM1 353047 Q7TSI1
Rat PLEKHM1 PLEKHM1 303584 Q5PQS0
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Top PLEKHM1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PLEKHM1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Pleckstrin Homology Domain Containing, Family M (With RUN Domain) Member 1 (PLEKHM1) Interaction Partners

Human Pleckstrin Homology Domain Containing, Family M (With RUN Domain) Member 1 (PLEKHM1) interaction partners

  1. identified PLEKHM1 as an endolysosomal adaptor platform that acts as a central hub to integrate endocytic and autophagic pathways at the lysosome

  2. Authors show that Pleckstrin (show PLEK Proteins) homology domain-containing protein family member 1 (PLEKHM1), a lysosomal adaptor, is targeted by Salmonella through direct interaction with SifA.

  3. PLEKHM1 regulates autophagosome-lysosome fusion through homotypic fusion and protein sorting complex and LC3 (show MAP1LC3A Proteins)/GABARAP (show GABARAP Proteins) proteins.

  4. Rubicon (show KIAA0226 Proteins) and PLEKHM1 specifically and directly interact with Rab7 (show RAB7B Proteins) via their RH domain; this interaction is critical for their function; show Rubicon (show KIAA0226 Proteins) but not PLEKHM1 uniquely regulates membrane trafficking via simultaneously binding both Rab7 (show RAB7B Proteins) and PI3-kinase (show PIK3CA Proteins)

  5. These data indicate that B2 is a novel, ubiquitously expressed protein with a putative adapter function. The protein has been named AP162.

  6. PLEKHM1 is a novel gene implicated in the development of osteopetrosis (show CSF1 Proteins), with a putative critical function in vesicular transport in the osteoclast.

  7. heterozygous mutation (R714C) of the osteopetrosis (show CSF1 Proteins) gene, pleckstrin (show PLEK Proteins) homolog domain containing family M (with run domain) member 1 (PLEKHM1), impairs vesicular acidification and increases TRACP (show ACP5 Proteins) secretion in osteoclasts

Mouse (Murine) Pleckstrin Homology Domain Containing, Family M (With RUN Domain) Member 1 (PLEKHM1) interaction partners

  1. TRAFD1 (show TRAFD1 Proteins), in association with Plekhm1/Rab7 (show RAB7A Proteins)-positive late endosomes-early lysosomes, has a previously unknown role in vesicle trafficking, acidification, and resorption in osteoclasts

  2. identified PLEKHM1 as an endolysosomal adaptor platform that acts as a central hub to integrate endocytic and autophagic pathways at the lysosome

  3. results indicate that LIS1 (show PAFAH1B1 Proteins) is a previously unrecognized regulator of osteoclast formation, microtubule organization, and lysosomal secretion by virtue of its ability to modulate dynein function and Plekhm1

PLEKHM1 Protein Profile

Protein Summary

The protein encoded by this gene is essential for bone resorption, and may play a critical role in vesicular transport in the osteoclast. Mutations in this gene are associated with autosomal recessive osteopetrosis type 6 (OPTB6). Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with PLEKHM1

  • pleckstrin homology domain containing, family M (with RUN domain) member 1 (PLEKHM1)
  • pleckstrin homology domain containing, family M (with RUN domain) member 1 (Plekhm1)
  • AP162 protein
  • B2 protein
  • BC038943 protein
  • D330036J23Rik protein
  • OPTB6 protein

Protein level used designations for PLEKHM1

pleckstrin homology domain containing, family M (with RUN domain) member 1 , 162 kDa adapter protein , PH domain-containing family M member 1 , pleckstrin homology domain-containing family M member 1

GENE ID SPECIES
454754 Pan troglodytes
490925 Canis lupus familiaris
9842 Homo sapiens
353047 Mus musculus
303584 Rattus norvegicus
100523462 Sus scrofa
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