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The protein encoded by PLEKHM1 is essential for bone resorption, and may play a critical role in vesicular transport in the osteoclast. Additionally we are shipping PLEKHM1 Antibodies (46) and many more products for this protein.
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identified PLEKHM1 as an endolysosomal adaptor platform that acts as a central hub to integrate endocytic and autophagic pathways at the lysosome
Authors show that Pleckstrin (show PLEK Proteins) homology domain-containing protein family member 1 (PLEKHM1), a lysosomal adaptor, is targeted by Salmonella through direct interaction with SifA.
PLEKHM1 regulates autophagosome-lysosome fusion through homotypic fusion and protein sorting complex and LC3 (show MAP1LC3A Proteins)/GABARAP (show GABARAP Proteins) proteins.
Rubicon (show KIAA0226 Proteins) and PLEKHM1 specifically and directly interact with Rab7 (show RAB7B Proteins) via their RH domain; this interaction is critical for their function; show Rubicon (show KIAA0226 Proteins) but not PLEKHM1 uniquely regulates membrane trafficking via simultaneously binding both Rab7 (show RAB7B Proteins) and PI3-kinase (show PIK3CA Proteins)
These data indicate that B2 is a novel, ubiquitously expressed protein with a putative adapter function. The protein has been named AP162.
PLEKHM1 is a novel gene implicated in the development of osteopetrosis (show CSF1 Proteins), with a putative critical function in vesicular transport in the osteoclast.
heterozygous mutation (R714C) of the osteopetrosis (show CSF1 Proteins) gene, pleckstrin (show PLEK Proteins) homolog domain containing family M (with run domain) member 1 (PLEKHM1), impairs vesicular acidification and increases TRACP (show ACP5 Proteins) secretion in osteoclasts
TRAFD1 (show TRAFD1 Proteins), in association with Plekhm1/Rab7 (show RAB7A Proteins)-positive late endosomes-early lysosomes, has a previously unknown role in vesicle trafficking, acidification, and resorption in osteoclasts
results indicate that LIS1 (show PAFAH1B1 Proteins) is a previously unrecognized regulator of osteoclast formation, microtubule organization, and lysosomal secretion by virtue of its ability to modulate dynein function and Plekhm1
The protein encoded by this gene is essential for bone resorption, and may play a critical role in vesicular transport in the osteoclast. Mutations in this gene are associated with autosomal recessive osteopetrosis type 6 (OPTB6). Alternatively spliced transcript variants have been found for this gene.
pleckstrin homology domain containing, family M (with RUN domain) member 1
, 162 kDa adapter protein
, PH domain-containing family M member 1
, pleckstrin homology domain-containing family M member 1