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anti-Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) Antibodies

Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). Additionally we are shipping Pleckstrin Homology Domain Containing, Family O Member 1 Proteins (7) and Pleckstrin Homology Domain Containing, Family O Member 1 Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PLEKHO1 51177 Q53GL0
PLEKHO1 67220 Q9JIY0
PLEKHO1 310674 Q5BJM5
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Top anti-Pleckstrin Homology Domain Containing, Family O Member 1 Antibodies at antibodies-online.com

Showing 10 out of 45 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of CKIP-1 Antibody (N-term) (ABIN652439) in 293 cell line lysates (35 µg/lane). CKIP-1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human skeletal muscle reacted with CKIP-1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of CKIP1 in human lung tissue lysate with AP30235PU-N CKIP1 antibody at (A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-PLEKHO1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: COLO205 cell lysate WB Suggested Anti-PLEKHO1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: COLO205 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE) Western blot analysis of CKIP1 in human lung tissue lysate with CKIP1 antibody at (A) 1 and (B) 2 µg/ml. 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti CKIP-1 Polyclonal Antibody, Unconjugated (ABIN675039) at 1:200 followed by conjugation to the secondary antibody and DAB staining Lane 1: mouse heart lysates Lane 2: mouse kidney lysates probed with Anti CKIP-1 Polyclonal Antibody, Unconjugated (ABIN675039) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 45kD. Observed band size: 45kD. 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IHC, ELISA, WB CKIP-1 staining in human lung cancer tissue. Formalin-fixed paraffin-embedded human lung cancer tissue is stained with CKIP-1 Antibody used at 1:200 dilution. 0.1 mg Log in to see 2 to 6 Days
$359.70
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (70.73 KDa) . 200 μL Log in to see 9 Days
$430.00
Details

PLEKHO1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
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Mouse (Murine) , ,


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Top referenced anti-Pleckstrin Homology Domain Containing, Family O Member 1 Antibodies

  1. Human Polyclonal PLEKHO1 Primary Antibody for EIA, WB - ABIN499637 : Zhang, Tie, Tian, Xing, Song, Zhu, Sun, He: CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM. in Cellular signalling 2006 (PubMed)
    Show all 4 references for ABIN499637

  2. Human Polyclonal PLEKHO1 Primary Antibody for EIA, WB - ABIN452845 : Barrios-Rodiles, Brown, Ozdamar, Bose, Liu, Donovan, Shinjo, Liu, Dembowy, Taylor, Luga, Przulj, Robinson, Suzuki, Hayashizaki, Jurisica, Wrana: High-throughput mapping of a dynamic signaling network in mammalian cells. in Science (New York, N.Y.) 2005 (PubMed)

More Antibodies against Pleckstrin Homology Domain Containing, Family O Member 1 Interaction Partners

Human Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) interaction partners

  1. There is a major role of the CK2alpha-interacting protein CKIP-1 in activation of PAK1 (show PAK1 Antibodies) for neoplastic prostate cells transformation.

  2. CKIP-1 interacts with CARMA1 (show CARD11 Antibodies) and has an inhibitory effect on PKCtheta (show PRKCQ Antibodies);-CBM-NF-kappaB (show NFKB1 Antibodies) signaling.

  3. CKIP-1 controlled Smurf1 (show SMURF1 Antibodies) expression in colon cancer

  4. overexpression triggers classical monocyte activation and transactivation of the TNF (show TNF Antibodies) promoter

  5. CKIP-1, through its leucine zipper, interacts with the Rpt6 and mediates the Smurf1 (show SMURF1 Antibodies)-Rpt6 interaction.

  6. CKIP-1 is involved in various important signaling pathways, controlling cell growth, apoptosis, differentiation, cytoskeleton and bone formation--REVIEW

  7. The N-terminal PH domain and C-terminal auto-inhibitory region of CKIP-1 coordinate to determine its subcellular localization and the nucleus-plasma membrane shuttling.

  8. examination of CK2alpha for a region that mediates interactions with CKIP-1 revealed a putative HIKE domain; this motif by itself may not be sufficient to mediate interactions.

  9. CKIP-1 plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (show TMOD4 Antibodies).

  10. CKIP-1 could interact with ATM (show ATM Antibodies) and recruits nuclear ATM (show ATM Antibodies) proteins partially to the plasma membrane. The results provide the first evidence that ATM (show ATM Antibodies), a predominantly nuclear kinase, could be re-localized to the plasma membrane.

Mouse (Murine) Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) interaction partners

  1. CKIP-1 is a novel inhibitor of MSC (show MSC Antibodies)-originated adipogenesis by enhancing HDAC1 (show HDAC1 Antibodies)-associated repression of C/EBPalpha (show CEBPA Antibodies).

  2. CKIP-1 interacts with TRAF6 (show TRAF6 Antibodies), a ubiquitin ligase (show RNF123 Antibodies) required for K63-linked ubiquitination and plasma membrane recruitment of Akt (show AKT1 Antibodies), and terminates TRAF6 (show TRAF6 Antibodies)-mediated Akt (show AKT1 Antibodies) activation.

  3. Knockdown of CKIP-1 in RAW264.7 macrophage cells resulted in impaired cell migration.

  4. CKIP-1 was found to be an inhibitor of cardiac hypertrophy by upregulating the dephosphorylation of HDAC4 through the recruitment of protein phosphatase 2A.

  5. CKIP-1 has a role in cell morphology that depends on its interaction with actin-capping protein (show TMOD4 Antibodies)

  6. CKIP-1 functions as the first auxiliary factor to enhance the activation of Smurf1 (show SMURF1 Antibodies).

Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) Antigen Profile

Protein Summary

Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation (By similarity).

Gene names and symbols associated with PLEKHO1

  • pleckstrin homology domain containing, family O member 1 (PLEKHO1) antibody
  • pleckstrin homology domain containing, family O member 1 (Plekho1) antibody
  • 2810052M02Rik antibody
  • CKIP-1 antibody
  • Ckip1 antibody
  • JZA-20 antibody
  • Jza2 antibody
  • OC120 antibody
  • RGD1311487 antibody

Protein level used designations for PLEKHO1

pleckstrin homology domain containing, family O member 1 , OC120 , 2810052M02Rik , C-Jun-binding protein , CK2 interacting protein 1; HQ0024c protein , CK2-interacting protein 1 , JBP , PH domain-containing family O member 1 , casein kinase 2-interacting protein 1 , osteoclast maturation-associated gene 120 protein , pleckstrin homology domain-containing family O member 1 , CK2 interacting protein 1 , Jun zipper-associated 2 , TNF intracellular domain-interacting protein

GENE ID SPECIES
457268 Pan troglodytes
607927 Canis lupus familiaris
706145 Macaca mulatta
100152184 Sus scrofa
100347162 Oryctolagus cuniculus
100444299 Pongo abelii
51177 Homo sapiens
67220 Mus musculus
310674 Rattus norvegicus
788251 Bos taurus
426108 Gallus gallus
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