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Pleckstrin Homology Domain Interacting Protein Proteins (PHIP)

PHIP binds the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS1\; MIM 147545), modulates insulin signaling, and plays a role in pancreatic beta cell growth and survival (Farhang-Fallah et al., 2000 [PubMed 11018022]\; Podcheko et al., 2007 [PubMed 17636024]).[supplied by OMIM, Jun 2009].. Additionally we are shipping Pleckstrin Homology Domain Interacting Protein Antibodies (16) and Pleckstrin Homology Domain Interacting Protein Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PHIP 55023 Q8WWQ0
Mouse PHIP PHIP 83946  
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Top Pleckstrin Homology Domain Interacting Protein Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag,DYKDDDDK Tag Recombinant PHIP (1302-1434) protein gel. PHIP (1302-1434) protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 100 μg Log in to see 1 to 2 Days
$460.83
Details

PHIP Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

More Proteins for Pleckstrin Homology Domain Interacting Protein (PHIP) Interaction Partners

Human Pleckstrin Homology Domain Interacting Protein (PHIP) interaction partners

  1. These results provide further support for PHIP as a molecular prognostic marker of melanoma, and reveal a significant linkage between PHIP levels and ulceration.

  2. The PHIP gene resides on 6q14.1, and although 6q loss has been observed in melanoma, the PHIP locus was preserved in melanoma cell lines and patient samples, and its overexpression was an independent adverse predictor of survival in melanoma patients.

Mouse (Murine) Pleckstrin Homology Domain Interacting Protein (PHIP) interaction partners

  1. Systemic, plasmid-based shRNA targeting of Phip inhibited the metastatic progression of melanoma, whereas stable suppression of Phip in melanoma cell lines suppressed metastatic potential and prolonged the survival of tumor-bearing mice.

  2. Together these results suggest that PHIP1 regulates postnatal growth in an IGF-1 (show IGF1 Proteins)/AKT (show AKT1 Proteins) pathway-independent manner.

  3. Identification of a WD40 (show DCAF12L2 Proteins) repeat-containing isoform of Phip as a novel regulator of beta-cell growth and survival.

Pleckstrin Homology Domain Interacting Protein (PHIP) Protein Profile

Protein Summary

PHIP binds the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS1\; MIM 147545), modulates insulin signaling, and plays a role in pancreatic beta cell growth and survival (Farhang-Fallah et al., 2000

Gene names and symbols associated with PHIP

  • pleckstrin homology domain interacting protein (PHIP)
  • pleckstrin homology domain interacting protein (phip)
  • pleckstrin homology domain interacting protein (Phip)
  • 2810004D21Rik protein
  • 4632404O06Rik protein
  • BRWD2 protein
  • DCAF14 protein
  • Ndrp protein
  • PHIP protein
  • Wdr11 protein

Protein level used designations for PHIP

pleckstrin homology domain interacting protein , WD repeat domain 11 , bromodomain and WD repeat domain containing 2 , WD repeat-containing protein 11-like , DDB1 and CUL4 associated factor 14 , IRS-1 PH domain-binding protein , PH-interacting protein , WD repeat-containing protein 11 , neuronal differentiation related protein , neuronal differentiation-related protein

GENE ID SPECIES
472253 Pan troglodytes
474976 Canis lupus familiaris
523186 Bos taurus
100158567 Xenopus (Silurana) tropicalis
100359323 Oryctolagus cuniculus
100389472 Callithrix jacchus
100482484 Ailuropoda melanoleuca
100597802 Nomascus leucogenys
55023 Homo sapiens
83946 Mus musculus
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