You are viewing an incomplete version of our website. Please click to reload the website as full version.

Pleckstrin Homology-Like Domain, Family A, Member 2 Proteins (PHLDA2)

PHLDA2 is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Additionally we are shipping Pleckstrin Homology-Like Domain, Family A, Member 2 Antibodies (81) and Pleckstrin Homology-Like Domain, Family A, Member 2 Kits (30) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PHLDA2 7262 Q53GA4
PHLDA2 22113 O08969
Rat PHLDA2 PHLDA2 293637  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Pleckstrin Homology-Like Domain, Family A, Member 2 Proteins at antibodies-online.com

Showing 10 out of 21 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$827.20
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 Days
$385.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,253.17
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,286.17
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,286.17
Details
Yeast REACT_Atlantic Salmon His tag   1 mg Log in to see 56 to 66 Days
$2,293.50
Details

PHLDA2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)
,

Top referenced Pleckstrin Homology-Like Domain, Family A, Member 2 Proteins

  1. Human PHLDA2 Protein expressed in Escherichia coli (E. coli) - ABIN667784 : Lee, Feinberg: Genomic imprinting of a human apoptosis gene homologue, TSSC3. in Cancer research 1998 (PubMed)
    Show all 2 references for ABIN667784

More Proteins for Pleckstrin Homology-Like Domain, Family A, Member 2 (PHLDA2) Interaction Partners

Human Pleckstrin Homology-Like Domain, Family A, Member 2 (PHLDA2) interaction partners

  1. TSSC3 downregulation promotes the Epithelial to mesenchymal transition (EMT) of osteosarcoma cells by regulating EMT markers via a signal transduction pathway that involves Snail, Wnt-beta-catenin/TCF, and GSK-3beta

  2. Placental PHLDA2 expression was significantly 2.3 fold higher in reduced fetal movements pregnancies resulting in delivery of a growth restricted compared with a normal birth weight infant.

  3. PHLDA2 may promote the occurrence/development of preeclampsia by inhibiting proliferation/migration/invasion of trophoblasts.

  4. The gene expression pattern of CDKN1C (show CDKN1C Proteins), H19 (show NCKAP1 Proteins), IGF2, KCNQ1 (show KCNQ1 Proteins) and PHLDA2 genes was evaluated using RT-PCR.

  5. results suggest upregulated pleckstrin homology-like domain family A member 2 (PHLDA2) in placenta of monozygotic twins may be associated with the pathogenesis of singleton intrauterine growth restriction

  6. TSSC3 overexpression suppressed osteosarcoma cell growth and increased apoptosis through caspase-3 (show CASP3 Proteins) upregulation, suggesting that TSSC3 may play a pro-apoptosis role to maintain the normal balance of growth

  7. TSSC3 inhibits osteosarcoma tumorigenicity through reducing stemness and promoting apoptosis of tumor inducing cells

  8. A luciferase reporter assay was used to identify in the PHLDA2 promoter a 15 bp repeat sequence variant that significantly reduces PHLDA2-promoter efficiency. Maternal inheritance of the variant resulted in a significant increase in birth weight.

  9. The results suggest that placental PHLDA2 may provide a biomarker for suboptimal skeletal growth in pregnancies uncomplicated by overt fetal growth restriction.

  10. TSSC3 has a potent tumor suppressor role in osteosarcoma, probably by inhibition of growth and induction of apoptosis via the mitochondrial apoptosis pathway.

Mouse (Murine) Pleckstrin Homology-Like Domain, Family A, Member 2 (PHLDA2) interaction partners

  1. Phlda2 manipulates the placenta's demands for maternal resources, a process that must be tightly regulated by epigenetic marks to ensure optimal foetal growth.

  2. data support a direct role for elevated Phlda2 in limiting fetal growth but also suggest that growth restriction only manifests when there is limited placental reserve

  3. TSSC3 plays an important role in the differentiation from trophoblast stem cell to trophoblast progenitors and/or labyrinth trophoblasts through the TSSC3/PI3K/AKT (show AKT1 Proteins)/MASH2 (show ASCL2 Proteins) signaling pathway.

  4. Phlda2 gene is imprinted, with preferential expression from the maternal allele in placenta. It acts as a rheostat for placental growth, with overgrowth after gene deletion and growth retardation after loss of imprinting.

  5. A critical role for the imprinted Phlda2 gene in regulating glycogen (show GYS1 Proteins) storage in the eutherian placenta is identified.

  6. Embryonic expression of Ipl in mice

  7. Ipl and Tih1 (show PHLDA3 Proteins) are bona fide PH domain proteins, with broad specificity and moderate affinity for PIPs (show GPRASP1 Proteins).

Pig (Porcine) Pleckstrin Homology-Like Domain, Family A, Member 2 (PHLDA2) interaction partners

  1. In the present study, a 259 base pair-specific sequence for IPL gene of the domestic pig was obtained and a novel SNP, a T/C transition, was identified in IPL exon 1. Variable imprinting status of this gene was observed in different developmental stages.

  2. Quantitative allelic sequencing supports maternal expression of PHLDA2 in fetal liver and placental tissues using an interbreed swine model.

Cow (Bovine) Pleckstrin Homology-Like Domain, Family A, Member 2 (PHLDA2) interaction partners

  1. imprinting status of four cattle genes (Tssc4 (show TSSC4 Proteins),Nap1l4 (show NAP1L4 Proteins), Phlda2 and Osbpl5 (show OSBPL5 Proteins)) in seven types of tissues, were assessed in cattle.

  2. proper expression levels of the imprinted genes CDKN1C (show CDKN1C Proteins) and PHLDA2 are critical for embryo development

  3. Pleckstrin homology-like domain family A member 2 (PHLDA2) gene is expressed across a range of cattle fetal tissues and stages. It provides the first evidence that PHLDA2 is a monoallelically expressed imprinted gene in cattle fetal tissues and placenta.

Pleckstrin Homology-Like Domain, Family A, Member 2 (PHLDA2) Protein Profile

Protein Summary

This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver.

Gene names and symbols associated with PHLDA2

  • pleckstrin homology-like domain, family A, member 2 (PHLDA2)
  • Pleckstrin homology-like domain family A member 2 (phla2)
  • pleckstrin homology-like domain, family A, member 2 (Phlda2)
  • pleckstrin homology-like domain, family A, member 2 (phlda2)
  • BRW1C protein
  • BWR1C protein
  • HLDA2 protein
  • Ipl protein
  • phlda2 protein
  • Tssc3 protein
  • zgc:110459 protein

Protein level used designations for PHLDA2

pleckstrin homology-like domain, family A, member 2 , pleckstrin homology-like domain family A member 2 , Imprinted in placenta and liver protein , beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein , imprinted in placenta and liver protein , p17-BWR1C , p17-Beckwith-Wiedemann region 1 C , p17-Beckwith-Wiedemann region 1C , tumor suppressing subchromosomal transferable fragment cDNA 3 , tumor suppressing subtransferable candidate 3 , tumor-suppressing STF cDNA 3 protein , tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein , tumor-supressing STF cDNA 3 , protein 50C15 , tumor-suppressing subchromosomal transferable fragment 3

GENE ID SPECIES
743049 Pan troglodytes
100196497 Salmo salar
7262 Homo sapiens
22113 Mus musculus
293637 Rattus norvegicus
100719774 Cavia porcellus
100379631 Sus scrofa
618810 Bos taurus
423088 Gallus gallus
100036975 Xenopus laevis
553622 Danio rerio
Selected quality suppliers for Pleckstrin Homology-Like Domain, Family A, Member 2 Proteins (PHLDA2)
Did you look for something else?