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anti-Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3) Antibodies

p53/TP53-regulated repressor of Akt/AKT1 signaling. Additionally we are shipping PHLDA3 Proteins (6) and PHLDA3 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PHLDA3 23612 Q9Y5J5
PHLDA3 27280 Q9WV95
PHLDA3 363989 Q5PQT7
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Top anti-PHLDA3 Antibodies at antibodies-online.com

Showing 10 out of 28 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-PHLDA3 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: 293T cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated EIA, WB HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human PHLDA3 with C-terminal MYC tag probed with AP23766PU-N (1 µg/ml) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with AP23766PU-N (1 mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Mouse Un-conjugated WB 100 μg Log in to see 7 to 8 Days
$434.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using PHLDA3 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Goat Un-conjugated ELISA   100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated IHC (p), ELISA 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated IHC, ELISA 100 μg Log in to see 11 to 16 Days
$412.86
Details
Human Rabbit Un-conjugated WB PHLDA3 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details

PHLDA3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
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Mouse (Murine) ,
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Rat (Rattus) ,
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Top referenced anti-PHLDA3 Antibodies

  1. Human Monoclonal PHLDA3 Primary Antibody for WB - ABIN2452076 : Kawase, Ohki, Shibata, Tsutsumi, Kamimura, Inazawa, Ohta, Ichikawa, Aburatani, Tashiro, Taya: PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt. in Cell 2009 (PubMed)
    Show all 2 references for ABIN2452076

  2. Human Polyclonal PHLDA3 Primary Antibody for WB - ABIN2785939 : Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in 2007 (PubMed)

  3. Human Polyclonal PHLDA3 Primary Antibody for ELISA - ABIN185126 : Frank, Mendelsohn, Ciccone, Svensson, Ohlsson, Tycko: A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting. in Mammalian genome : official journal of the International Mammalian Genome Society 2000 (PubMed)

More Antibodies against PHLDA3 Interaction Partners

Human Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3) interaction partners

  1. Low PHLDA3 expression in ESCC may be predictive of tumor recurrence suggesting that Akt (show AKT1 Antibodies) activation may be a therapeutic target in ESCCs

  2. Results indicate that tumor suppressor PHLDA3-mediated pathway is important in the development of pancreatic neuroendocrine tumors (PanNETs).

  3. findings indicate somatic mutation of PHLDA3 is rare in common cancer types; PHLDA3 expression was lost in 22% of prostate cancers; these results indicate that PHLDA3 are altered in prostate cancers by loss of expression

  4. Study identifies PHLDA3 as a p53 (show TP53 Antibodies) target gene that encodes a PH domain-only protein and finds that PHLDA3 competes with the PH domain of Akt (show AKT1 Antibodies) for binding of membrane lipids, inhibiting Akt (show AKT1 Antibodies) translocation to the cellular membrane and activation.

Mouse (Murine) Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3) interaction partners

  1. Phlda3 may cause p53 (show TP53 Antibodies) accumulation through a feedforward pathway, facilitating tubular injury and its urine excretion.

  2. Data indicate that tumor suppressor PHLDA3-deficient mice develop islet hyperplasia.

  3. Ipl (show PHLDA2 Antibodies) and Tih1 are bona fide PH domain proteins, with broad specificity and moderate affinity for PIPs (show GPRASP1 Antibodies).

PHLDA3 Antigen Profile

Protein Summary

p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its directs transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May acts as a tumor suppressor (By similarity).

Gene names and symbols associated with PHLDA3

  • pleckstrin homology-like domain, family A, member 3 (PHLDA3) antibody
  • pleckstrin homology-like domain, family A, member 3 (Phlda3) antibody
  • pleckstrin homology-like domain, family A, member 3 (phlda3) antibody
  • si:dz182n13.5 antibody
  • Tih1 antibody
  • zgc:92333 antibody

Protein level used designations for PHLDA3

pleckstrin homology-like domain, family A, member 3 , TDAG51/Ipl homolog 1 , pleckstrin homology-like domain family A member 3 , pleckstrin homology-like domain, family A, member 2 , TDAG/lpl homolog 1

GENE ID SPECIES
457620 Pan troglodytes
23612 Homo sapiens
27280 Mus musculus
363989 Rattus norvegicus
368779 Danio rerio
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