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Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3) ELISA Kits

p53/TP53-regulated repressor of Akt/AKT1 signaling. Additionally we are shipping PHLDA3 Antibodies (31) and PHLDA3 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
PHLDA3 23612 Q9Y5J5
Anti-Mouse PHLDA3 PHLDA3 27280 Q9WV95
Anti-Rat PHLDA3 PHLDA3 363989 Q5PQT7
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Top PHLDA3 ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human
96 Tests Log in to see 11 to 13 Days
$910.56
Details

More ELISA Kits for PHLDA3 Interaction Partners

Human Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3) interaction partners

  1. Low PHLDA3 expression in ESCC may be predictive of tumor recurrence suggesting that Akt (show AKT1 ELISA Kits) activation may be a therapeutic target in ESCCs

  2. Results indicate that tumor suppressor PHLDA3-mediated pathway is important in the development of pancreatic neuroendocrine tumors (PanNETs).

  3. findings indicate somatic mutation of PHLDA3 is rare in common cancer types; PHLDA3 expression was lost in 22% of prostate cancers; these results indicate that PHLDA3 are altered in prostate cancers by loss of expression

  4. Study identifies PHLDA3 as a p53 (show TP53 ELISA Kits) target gene that encodes a PH domain-only protein and finds that PHLDA3 competes with the PH domain of Akt (show AKT1 ELISA Kits) for binding of membrane lipids, inhibiting Akt (show AKT1 ELISA Kits) translocation to the cellular membrane and activation.

Mouse (Murine) Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3) interaction partners

  1. Phlda3 may cause p53 (show TP53 ELISA Kits) accumulation through a feedforward pathway, facilitating tubular injury and its urine excretion.

  2. Data indicate that tumor suppressor PHLDA3-deficient mice develop islet hyperplasia.

  3. Ipl (show PHLDA2 ELISA Kits) and Tih1 are bona fide PH domain proteins, with broad specificity and moderate affinity for PIPs (show GPRASP1 ELISA Kits).

PHLDA3 Antigen Profile

Antigen Summary

p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its directs transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May acts as a tumor suppressor (By similarity).

Gene names and symbols associated with PHLDA3

  • pleckstrin homology-like domain, family A, member 3 (PHLDA3) antibody
  • pleckstrin homology-like domain, family A, member 3 (Phlda3) antibody
  • pleckstrin homology-like domain, family A, member 3 (phlda3) antibody
  • si:dz182n13.5 antibody
  • Tih1 antibody
  • zgc:92333 antibody

Protein level used designations for PHLDA3

pleckstrin homology-like domain, family A, member 3 , TDAG51/Ipl homolog 1 , pleckstrin homology-like domain family A member 3 , pleckstrin homology-like domain, family A, member 2 , TDAG/lpl homolog 1

GENE ID SPECIES
457620 Pan troglodytes
23612 Homo sapiens
27280 Mus musculus
363989 Rattus norvegicus
368779 Danio rerio
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