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Pleckstrin Homology-Like Domain, Family A, Member 3 Proteins (PHLDA3)

p53/TP53-regulated repressor of Akt/AKT1 signaling. Additionally we are shipping PHLDA3 Antibodies (31) and PHLDA3 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PHLDA3 23612 Q9Y5J5
PHLDA3 27280 Q9WV95
Rat PHLDA3 PHLDA3 363989 Q5PQT7
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Top PHLDA3 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,258.67
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PHLDA3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3) Interaction Partners

Human Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3) interaction partners

  1. Low PHLDA3 expression in ESCC may be predictive of tumor recurrence suggesting that Akt (show AKT1 Proteins) activation may be a therapeutic target in ESCCs

  2. Results indicate that tumor suppressor PHLDA3-mediated pathway is important in the development of pancreatic neuroendocrine tumors (PanNETs).

  3. findings indicate somatic mutation of PHLDA3 is rare in common cancer types; PHLDA3 expression was lost in 22% of prostate cancers; these results indicate that PHLDA3 are altered in prostate cancers by loss of expression

  4. Study identifies PHLDA3 as a p53 (show TP53 Proteins) target gene that encodes a PH domain-only protein and finds that PHLDA3 competes with the PH domain of Akt (show AKT1 Proteins) for binding of membrane lipids, inhibiting Akt (show AKT1 Proteins) translocation to the cellular membrane and activation.

Mouse (Murine) Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3) interaction partners

  1. Phlda3 may cause p53 (show TP53 Proteins) accumulation through a feedforward pathway, facilitating tubular injury and its urine excretion.

  2. Data indicate that tumor suppressor PHLDA3-deficient mice develop islet hyperplasia.

  3. Ipl (show PHLDA2 Proteins) and Tih1 are bona fide PH domain proteins, with broad specificity and moderate affinity for PIPs (show GPRASP1 Proteins).

PHLDA3 Protein Profile

Protein Summary

p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its directs transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May acts as a tumor suppressor (By similarity).

Gene names and symbols associated with PHLDA3

  • pleckstrin homology-like domain, family A, member 3 (PHLDA3)
  • pleckstrin homology-like domain, family A, member 3 (Phlda3)
  • pleckstrin homology-like domain, family A, member 3 (phlda3)
  • si:dz182n13.5 protein
  • Tih1 protein
  • zgc:92333 protein

Protein level used designations for PHLDA3

pleckstrin homology-like domain, family A, member 3 , TDAG51/Ipl homolog 1 , pleckstrin homology-like domain family A member 3 , pleckstrin homology-like domain, family A, member 2 , TDAG/lpl homolog 1

GENE ID SPECIES
457620 Pan troglodytes
23612 Homo sapiens
27280 Mus musculus
363989 Rattus norvegicus
368779 Danio rerio
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