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Pleiomorphic Adenoma Gene-Like 1 Proteins (PLAGL1)

PLAGL1 encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities. Additionally we are shipping PLAGL1 Antibodies (50) and PLAGL1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PLAGL1 5325 Q9UM63
Mouse PLAGL1 PLAGL1 22634  
Rat PLAGL1 PLAGL1 25157  
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Top PLAGL1 Proteins at

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 16 Days

PLAGL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for Pleiomorphic Adenoma Gene-Like 1 (PLAGL1) Interaction Partners

Human Pleiomorphic Adenoma Gene-Like 1 (PLAGL1) interaction partners

  1. High PLAGL1 mRNA and protein levels were associated with Clear Cell Renal Cell Carcinoma (show MOK Proteins).

  2. Results suggest that dysregulation of PLAGL1 expression may be involved in the progression of colorectal cancer (CRC (show CALR Proteins)) but the patient survival data do not confirm applicability of the PLAGL1 expression level as a prognostic factor in CRC (show CALR Proteins).

  3. Fetal growth can be influenced by altered expression of the PLAGL1 gene network in human placenta.

  4. DNA deletion and promoter hyper-methylation both contribute to the down-regulation of PLAGL1 in gastric adenocarcinoma

  5. There is positive correlations between the ZAC1 DMR (show WDR20 Proteins) methylation index (MI) and estimated fetal weight (EFW) at 32 weeks of gestation, weight at birth and weight at one year of age (respectively, r = 0.15, 0.09, 0.14; P values = 0.01, 0.15, 0.03).

  6. ZAC1 and SSTR2 (show SSTR2 Proteins) are down-regulated in non-functioning pituitary adenomas but not in somatotropinomas.

  7. Paternal methylation aberrations at imprinting control regions of DLK1 (show DLK1 Proteins)-GTL2, MEST (PEG1 (show MEST Proteins)), and ZAC (PLAGL1) and global methylation levels are not associated with idiopathic recurrent spontaneous miscarriages.

  8. The imprinted PLAGL1 domain is flanked by CTCF (show CTCF Proteins)-binding sites conserved between species in both expressing and non-expressing cells.

  9. Based on these findings we conclude that the imprinted gene expression of KCNQ1OT1, CDKN1C (show CDKN1C Proteins), H19 (show NCKAP1 Proteins), and PLAGL1 are conserved between human and bovine

  10. detected a synonymous variation in the protein-coding exon-2 of PLAGL1 in isolated VSD patients. It is possible that the etiology of isolated VSD might not be directly linked with this mutation

Pig (Porcine) Pleiomorphic Adenoma Gene-Like 1 (PLAGL1) interaction partners

  1. PLAGL1 is maternally imprinted in swine. Expression profiling using short-oligonucleotide microarrays of parthenotes and control fetal tissues supports imprinted isoform-specific expression.

  2. The expression patterns of PLAGL1 and PEG10 (show PEG10 Proteins) genes in two breeds of swine are reported.

Mouse (Murine) Pleiomorphic Adenoma Gene-Like 1 (PLAGL1) interaction partners

  1. expression levels of Zac1 need to be kept under strict control to avoid premature cell cycle exit, disrupted neurogenesis and aberrant expression of non-neuronal genes including pluripotency associated factors.

  2. Transcription factor MEF2 (show MEF2C Proteins) and Zac1 mediate MIF (show MIF Proteins)-induced GLUT4 (show SLC2A4 Proteins) expression through CD74 (show CD74 Proteins)-dependent AMPK (show PRKAA1 Proteins) activation in cardiomyocytes

  3. we show that the maternally imprinted gene Zac1 is a critical regulator of neocortical development

  4. Zac1 interacts with two cis (show CISH Proteins)-regulatory elements in the Tcf4 (show TCF4 Proteins) gene locus.

  5. results indicate ZAC is a negative regulator of the acute stimulatory effects of glucose on beta-cells. It provides an explanation for both insulin (show INS Proteins) deficiency in the neonate and the later relapse of diabetes in patients with transient neonatal diabetes mellitus cases

  6. Hymai and Plagl1it RNAs both have potentially high affinity for Trithorax (show MLLT1 Proteins) chromatin regulators.

  7. identified the guanine nucleotide exchange factor Rasgrf1 (show RASGRF1 Proteins) as a direct Zac1/Plagl1 target gene in beta cells

  8. Zac1 inhibits nuclear factor Kappa B activity by interacting with the C-terminus of the p65 (show NFkBP65 Proteins) subunit, which suppresses the phosphorylation of p65 (show NFkBP65 Proteins) at Ser468 and Ser536 residues

  9. the different expression pattern of Zac1 in mice from human may explain the much milder phenotype in the mouse model of ZAC double dose

  10. The Zac1 is a critical regulator of normal cerebellar development, adding a new transcriptional regulator to the growing list of factors involved in generating neuronal diversity in the developing cerebellum.

PLAGL1 Protein Profile

Protein Summary

This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities. It has been shown to have anti-proliferative properties, and thus thought to function as a tumor suppressor. In addition, overexpression of this gene during fetal development is believed to underlie the rare disorder, transient neonatal diabetes mellitus (TNDM). This gene is imprinted, with preferential expression of the paternal allele in many tissues, however, biallelic expression has been noted in peripheral blood leucocytes. A recent study reports that tissue-specific imprinting results from variable utilization of monoallelic and biallelic promoters. Many transcript variants differing in the 5' UTR and encoding two different isoforms, have been found for this gene.

Gene names and symbols associated with PLAGL1

  • pleiomorphic adenoma gene-like 1 (PLAGL1)
  • pleiomorphic adenoma gene-like 1 (LOC100219396)
  • pleiomorphic adenoma gene-like 1 (LOC100350914)
  • pleiomorphic adenoma gene-like 1 (Plagl1)
  • Lot1 protein
  • PLAGL1 protein
  • ZAC protein
  • Zac1 protein

Protein level used designations for PLAGL1

pleiomorphic adenoma gene-like 1 , zinc finger protein PLAGL1-like , LOT-1 , PLAG-like 1 , lost on transformation 1 , pleiomorphic adenoma-like protein 1 , tumor suppressor ZAC , tumor supressor ZAC , zinc finger protein PLAGL1 , zinc finger protein Zac 1 , zinc finger protein regulator of apoptosis and cell cycle arrest , Lost on transformation 1

463042 Pan troglodytes
699985 Macaca mulatta
100219396 Taeniopygia guttata
100350914 Oryctolagus cuniculus
100407778 Callithrix jacchus
100441551 Pongo abelii
100584649 Nomascus leucogenys
5325 Homo sapiens
484018 Canis lupus familiaris
733596 Sus scrofa
539761 Bos taurus
22634 Mus musculus
25157 Rattus norvegicus
421664 Gallus gallus
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