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Pleiomorphic adenoma gene-like 2 is a zinc-finger protein that recognizes DNA and/or RNA. Additionally we are shipping PLAGL2 Antibodies (11) and many more products for this protein.
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PLAGL2 expression induces lamellipodia formation and disruption of stress fiber formation.
PLAGL2 regulate cell cycle and apoptosis via activation of the p53 (show TP53 Proteins) family member, p73 (show TP73 Proteins), in human promonocytic U937 cells.
Transcriptome analysis revealed that these differentiation-suppressive activities are attributable in part to PLAGL2 modulation of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling
The data identify PC2 (show KRT6B Proteins) as a novel PLAGL2-binding protein and important mediator of PLAGL2 transactivation.
PLAGL2 may modulate SP-C (show SFTPC Proteins) expression during lung development.
Plag1 (show PLAG1 Proteins) and Plagl2 are novel leukemia oncogenes that act by expanding hematopoietic progenitors expressing CbF beta (show CBFB Proteins)-SMMHC (show MYH11 Proteins).
These data clearly identify PLAGL2 as a novel regulator of NCF2/p67phox (show NCF2 Proteins) gene expression as well as NADPH oxidase (show NOX1 Proteins) activity and contribute to a greater understanding of the transcriptional regulation of NCF2 (show NCF2 Proteins).
Coexpression of Tip60 (show KAT5 Proteins) and PLAGL2 completely abolishes the sumoylation of PLAGL2.
Nuclear PLAGL2 occupied and transactivated the endogenous SP-C (show SFTPC Proteins) promoter in hypoxic lung cells.These results further suggest that PLAGL2 is an oxidative stress responding regulator in lung cells.
This study thus uncovers a novel function of PLAGL2 as an oncoprotein through regulating the stability of Pirh2 (show RCHY1 Proteins).
induces the expression of a proapoptotic protein Nip3, leading to cellular apoptosis.
PlagL2 regulates important aspects of dietary lipid absorption, and the PlagL2(-/-) animal model has implications for the amelioration of obesity and the metabolic syndrome.
Increased cell injury and/or death could be caused directly by the upregulation of bNip3 (show BNIP3 Proteins), a preapoptotic molecule that dimerizes with Bcl-2 (show BCL2 Proteins), or indirectly by the aberrant expression of SP-C (show SFTPC Proteins)-induced endoplasmic reticulum stress in epithelial cells.
Pleiomorphic adenoma gene-like 2 is a zinc-finger protein that recognizes DNA and/or RNA.
zinc finger protein PLAGL2
, pleiomorphic adenoma gene-like 2
, zinc finger protein PLAGL2-like
, C2H2-type zinc finger protein
, pleiomorphic adenoma-like protein 2
, pleomorphic adenoma gene like 2