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Plxna2 encodes a member of the plexin-A family of semaphorin co-receptors. Additionally we are shipping Plexin A2 Antibodies (39) and Plexin A2 Kits (8) and many more products for this protein.
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Sema6a (show SEMA6A Proteins) and Plxna2 have roles in promoting eye vesicle cohesion through mediating spatially regulated repulsion within the developing zebrafish eye
Data indicate that plexin A1 (show PLXNA1 Proteins)-4 (PLXNA1 (show PLXNA1 Proteins)-4) mediation of neuroanatomical traits can be detected using in vivo neuroimaging techniques.
although plexin-A4 (show PLXNA4 Proteins) overexpression restored Sema3A (show SEMA3A Proteins) signaling in plexin-A1 (show PLXNA1 Proteins)-silenced cells, it failed to restore Sema3B (show SEMA3B Proteins) signaling in plexin-A2-silenced cells.
PLXNA2 upregulation contributes to TMPRSS2 (show TMPRSS2 Proteins):ERG (show ERG Proteins)-mediated enhancements of PC3c cell migration and invasion.
PLXNA2 has been identified as a new rare copy number variations gene for tetralogy of Fallot.
results of our study reveal that PlxnA2 has a pro-osteogenic function by modulating BMP2 (show BMP2 Proteins) signaling
PLXNA2 polymorphisms show association with ankylosing spondylitis.
in vitro analysis of PLXNA2 revealed that the gene has higher expression in more aggressive breast cancer cell types.
An association is identified between variants in the PLXNA2 gene and schizophrenia in two collections of schizophrenia cases and controls. High-density SNP mapping showed that the region of association spans approximately 60 kb of the PLXNA2 gene.
results suggest that PLXNA2 may not play a major role in the development of schizophrenia in our Japanese sample
PLXNA2 confers a varying genetic risk for schizophrenia among different populations.
Plexin A2 is expressed in both On and Off starburst amacrine cell.
crystal structures of cognate complexes of the semaphorin-binding regions of plexins B1 and A2 with semaphorin ectodomains (human PLXNB1 (show PLXNB1 Proteins)(1-2)-SEMA4D (show SEMA4D Proteins)(ecto (show TRIM33 Proteins)) and murine PlxnA2(1-4)-Sema6A (show SEMA6A Proteins)(ecto (show TRIM33 Proteins))), plus unliganded structures of PlxnA2(1-4) and Sema6A (show SEMA6A Proteins)(ecto (show TRIM33 Proteins))
crystal structures of the semaphorin 6A (Sema6A (show SEMA6A Proteins)) receptor-binding fragment and the plexin A2 (PlxnA2) ligand-binding fragment in both their pre-signalling (that is, before binding) and signalling (after complex formation) states
This study demonstrated that Sema6B (show SEMA6B Proteins), another class 6 transmembrane semaphorin, is expressed in CA3 (show CA3 Proteins) and repels mossy fibers in a PlxnA4 (show PLXNA4 Proteins)-dependent manner in vitro.
In plexin-A2-deficient mice many granule cells remained in the molecular layer; mouse chimera studies further suggested that plexin-A2 acts in a cell-autonomous manner.
mutations in GATA6 (show GATA6 Proteins) are genetic causes of congenital heart diseases involving outflow tract defects, as a result of the disruption of the direct regulation of semaphorin 3C (show SEMA3C Proteins)-plexin A2 signaling
This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C.
, plexin A2
, plexin 2
, semaphorin receptor OCT
, transmembrane protein OCT
, plex 2