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Involved in the development of primary sensory neurons especially in branching of the peripheral axons. Additionally we are shipping Plexin A4 Antibodies (42) and Plexin A4 Kits (1) and many more products for this protein.
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Data indicate that plexin A1 (show PLXNA1 Proteins)-4 (PLXNA1 (show PLXNA1 Proteins)-4) mediation of neuroanatomical traits can be detected using in vivo neuroimaging techniques.
There is a significant association between Alzheimer's disease risk and SNPs in PLXNA4.
Rare variants in PLXNA4 and Parkinson's disease.
Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF (show VEGFA Proteins) and bFGF (show FGF2 Proteins) signaling.
Distinct cytoplasmic domains in Plexin-A4 mediate diverse responses to semaphorin 3A (show SEMA3A Proteins) in developing mammalian neurons.
results suggest that Plexin-A4 is involved in the precise positioning of oligodendrocyte precursor cells in developing cerebral cortex.
null mutations in Sema6A (show SEMA6A Proteins) or PlexinA4 (PlexA4) exhibit a pronounced defect in OPL (show ZIC1 Proteins) stratification of horizontal cell axons without any apparent deficits in bipolar cell dendrite or photoreceptor axon targeting.
Findings suggest plexin-A4 and Sema3A (show SEMA3A Proteins) as new intervention points for treating sepsis.
suggesting that a Semaphorin6A-Plexin-A4 cis (show CISH Proteins) interaction serves as an inhibitory mechanism.
plexin-A4 was expressed in the developing nervous system with a pattern different to that of other members of the plexin-A subfamily (plexin-A1 (show PLXNA1 Proteins), plexin-A2 (show Plxna2 Proteins) and plexin-A3 (show PLXNA3 Proteins))
PlexA4 expressed in oligodendrocyte precursor cells acts as a mediator of semaphorin signals
plexin-A4, as a component of the receptor complex for class III semaphorins, negatively regulates T cell-mediated immune responses
plexin-A3 (show PLXNA3 Proteins) and plexin-A4 are expressed in newly-differentiated sympathetic neurons, but not their neural crest precursors. They function cooperatively to regulate the migration of sympathetic neurons and then differentially to guide the sympathetic axons.
These results indicate that the stereotyped pruning of the visual and motor CST (show CORT Proteins) axon collaterals is differentially regulated and that this specificity arises from the differential expression of plexin receptors in the cortex.
Involved in the development of primary sensory neurons especially in branching of the peripheral axons. Interacts with the SLIT2 signaling specifically to promote axonal branching of Rohon-Beard neurons and the trigeminal sensory ganglion neurons.
, plexin A4, A
, plexin A4
, putative plexin 2