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Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. Additionally we are shipping Plexin B2 Proteins (6) and Plexin B2 Kits (1) and many more products for this protein.
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Mouse (Murine) Monoclonal Plexin B2 Primary Antibody for FACS - ABIN2662832
Roney, OConnor, Wen, Holl, Guthrie, Davis, Jones, Jha, Sharek, Garcia-Mata, Bear, Ting: Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation. in PLoS ONE 2011
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Results show that decreased expression of Sema4D (show SEMA4D Antibodies), plexin-B1 (show PLXNB1 Antibodies) and -B2 was associated with local recurrence and poor prognosis of breast neoplasm.
Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF (show ARHGEF11 Antibodies) and leukemia-associated RhoGEF (LARG (show ARHGEF12 Antibodies)), use their PDZ (show INADL Antibodies) domains to bind class B plexins and play critical roles in signaling.
Plexin-B2 promotes glioma invasion and vascularization
Blocking of CD100 (show SEMA4D Antibodies), plexin B1 (show PLXNB1 Antibodies) and/or B2 in adhesion experiments have shown that both CD100 (show SEMA4D Antibodies) and plexins act as adhesion molecules involved in monocyte-endothelial cell binding.
In endometrial luminal epithelium, cadherin 6 (show CDH6 Antibodies), desmoglein 2 (show DSG2 Antibodies) and plexin b2 were surprisingly found in the apical as well as the lateral membrane domain; their knock-down compromised epithelial integrity.
High PLEXIN B2 expression is associated with high-grade gliomas.
Plexin B2 associates directly with two members of a recently identified family of Dbl (show MCF2 Antibodies) homology/pleckstrin (show PLEK Antibodies) homology containing guanine nucleotide exchange factors for Rho, PDZ-RhoGEF (show ARHGEF11 Antibodies), and Leukemia-associated Rho GEF (show SLC2A4RG Antibodies) (LARG (show ARHGEF12 Antibodies)).
During kidney morphogenesis and repair, renal tubular epithelial cells lacking the transmembrane receptor Plexin-B2 or its semaphorin ligands fail to correctly orient the mitotic spindle
Data show that the Plexin B2 receptor interacts physically and functionally with Rnd3 (show RND3 Antibodies) and stimulates RhoA (show RHOA Antibodies) activity in migrating cortical neurons.
In contrast to the GAP domain mutants, Plexin-B2 transgenic mice defective in Rho guanine nucleotide exchange factor (show ARHGEF28 Antibodies) binding are viable and fertile but exhibit abnormal development of the liver vasculature
these results show that Plexin-B2 plays a role in postnatal neurogenesis and in the migration of subventricular zone-derived neuroblasts
Data an association between Plexin-B2 and Plexin-D1 (show PLXND1 Antibodies) with the negative regulation of IL-12 (show IL12A Antibodies)/IL-23p40 in DCs.
In vitro blocking of plexin B2 or CD100 (show SEMA4D Antibodies) inhibited gamma-delta T cell activation.
Data show that Plexin-B2 functions in macrophages as a negative regulator of the GTPases Rac (show AKT1 Antibodies) and Cdc42 (show CDC42 Antibodies) and as a negative regulator of basal cell motility and wound healing.
deletion of Plexin B2 (Plxnb2), a semaphorin receptor that is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney, results in renal hypoplasia and occasional double ureters
We have identified here Sema4C (show SEMA4C Antibodies) and Sema4G (show SEMA4G Antibodies) as candidate ligands for Plexin-B2
Plexin-B2 and Sema4C (show SEMA4C Antibodies) are potential regulators of the vascular and endocrine system.
Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002)
, differentially expressed in brain tumors