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PVRL1 encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. Additionally we are shipping Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) Proteins (19) and Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) Kits (11) and many more products for this protein.
Showing 10 out of 64 products:
Human Monoclonal PVRL1 Primary Antibody for FACS - ABIN2662946
Akhtar, Tiwari, Oh, Kovacs, Jani, Kovacs, Valyi-Nagy, Shukla: HVEM and nectin-1 are the major mediators of herpes simplex virus 1 (HSV-1) entry into human conjunctival epithelium. in Investigative ophthalmology & visual science 2008
Show all 6 references for ABIN2662946
Human Monoclonal PVRL1 Primary Antibody for ELISA - ABIN1998923
Haarr, Shukla, Rødahl, Dal Canto, Spear: Transcription from the gene encoding the herpesvirus entry receptor nectin-1 (HveC) in nervous tissue of adult mouse. in Virology 2001
nectin-1 regulates the neuronal activities in the CA3 (show CA3 Antibodies) region of the hippocampus.
Novel type of cell adhesion apparatus is mediated by Nectin-1 and Nectin-4 (show PVRL4 Antibodies). It's implicated in prolactin receptor (show PRLR Antibodies) signaling for mammary gland development.
These results indicate that the nectin-1 spots regulate the branching of mitral cell dendrites in the deep sub-lamina of the EPL and suggest that the nectin-1 spots are required for odor information processing in the olfactory bulb.
Results indicate that the nectin-1 spots constitute a novel adhesion apparatus that tethers mitral cell dendrites in a dendritic meshwork structure of the developing mouse olfactory bulb
results demonstrate a role for both nectin-1 and HVEM (show TNFRSF14 Antibodies) as receptors and suggest a further receptor which appears much less efficient.
Pvrl1 is a bona fide target gene of the transcription factor p63 (show CKAP4 Antibodies), whereas Pvrl4 (show PVRL4 Antibodies) regulation is linked to epidermal differentiation and is under Irf6 (show IRF6 Antibodies)
In summary, herpes simplex virus 1 entry into epidermis was shown to strongly depend on the presence of nectin-1, but the restricted presence of HVEM (show TNFRSF14 Antibodies) can potentially replace nectin-1 as a receptor.
This study demonstrated that nectin1- and nectin3 (show PVRL3 Antibodies)-mediated interactions between Cajal-Retzius cells cells and migrating neurons are critical for radial migration
PRR1 nectin-1 plays a role in the formation of intimal thickening after carotid artery ligation.
Nectin-1-specific entry of herpes simplex virus 1 is sufficient for infection of the cornea and viral spread to the trigeminal ganglia.
mutations in exons 2 and 5 of PVRL1, and T334A, A391T, G1183A in the alpha-spliced transcript, and G1082T in the beta-spliced transcript do not participate in the development of non-syndromic cleft of the lip and/or palate in patients from Guangdong.
data suggests that E-cadherin regulates assembly of nectin junctions through alpha-catenin-induced remodeling of the actin cytoskeleton around the cadherin clusters.
The results showed that the interface between the BV gD and nectin-1 molecule is not geometrically complementary.
These data provided solid structural and functional evidence that herpes simplex virus 1 and herpes simplex virus 2 gD proteins recognize nectin-1 via the same binding mode.
Authors show that the same key residues in the BC and FG loops of nectin-4 (show PVRL4 Antibodies) govern binding to the measles virus attachment protein hemagglutinin (show HA Antibodies) (H) and cell entry, nectin-4 (show PVRL4 Antibodies) homodimerization, and heterodimerization with nectin-1.
Host nectin-1 is required for efficient Chlamydia trachomatis serovar E development.
These results suggest that HVEM (show TNFRSF14 Antibodies) might play more important roles than CD28 (show CD28 Antibodies) in ConA-mediated T cell proliferation
We identified new supportive evidence that the association between PVRL1 gene and nsCL (show NHLH1 Antibodies)/P in Turkish patients.
Glycoprotein D (show DARC Antibodies) (gD) epitope core structure maps to the external surface of herpesvirus (HSV) gD, corresponding to the binding sites of two receptors, herpesvirus entry mediator (HVEM (show TNFRSF14 Antibodies)) and nectin-1, which mediate HSV infection.
The conformation of the N-terminus of herpes simplex virus gD is induced by direct binding to HVEM (show TNFRSF14 Antibodies) and nectin-1.
Contribution of the second and third Ig-like domains of nectin-1 was analysed by generating transgenic mice expressing the entire ectodomain of nectin-1 fused to the porcine Fc portion.
Results demonstrate that a soluble form of the first domain of porcine nectin-1 is able to exert a significant antiviral effect against pseudorabies virus infection.
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.
poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin)
, herpesvirus entry mediator C
, poliovirus receptor related protein
, poliovirus receptor-related protein 1
, nectin 2
, poliovirus receptor-related 1 (herpesvirus entry mediator C)
, Poliovirus receptor-related protein 1
, poliovirus receptor-related 1
, herpes virus entry mediator C
, nectin-1 alpha
, nectin-1 delta
, poliovirus receptor-related 1 (herpesvirus entry mediator C
, ectodermal dysplasia 4 (Margarita Island type)
, herpesvirus Ig-like receptor
, nectin 1
, poliovirus receptor-like 1