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Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) Proteins (PVRL1)

PVRL1 encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. Additionally we are shipping Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) Antibodies (73) and Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PVRL1 58235 Q9JKF6
PVRL1 192183  
PVRL1 5818 Q15223
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Top Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$275.00
Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Rat His tag 100 μg Log in to see 16 Days
$382.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_HEK-293 Human His tag 50 μg Log in to see 2 to 3 Days
$630.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK-293 Human His tag   0.1 mg Log in to see 2 to 3 Days
$515.63
Details

PVRL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Rat (Rattus)
,
Human , , , , , , ,
, , ,

Top referenced Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) Proteins

  1. Human PVRL1 Protein expressed in Human Cells - ABIN2004429 : Lopez, Cocchi, Avitabile, Leclerc, Adelaide, Campadelli-Fiume, Dubreuil: Novel, soluble isoform of the herpes simplex virus (HSV) receptor nectin1 (or PRR1-HIgR-HveC) modulates positively and negatively susceptibility to HSV infection. in Journal of virology 2001 (PubMed)
    Show all 7 references for ABIN2004429

  2. Rat (Rattus) PVRL1 Protein expressed in Human Cells - ABIN2009371 : Reymond, Fabre, Lecocq, Adelaïde, Dubreuil, Lopez: Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction. in The Journal of biological chemistry 2001 (PubMed)
    Show all 5 references for ABIN2009371

  3. Human PVRL1 Protein expressed in HEK-293 Cells - ABIN2181679 : Lopez, Eberlé, Mattei, Gabert, Birg, Bardin, Maroc, Dubreuil: Complementary DNA characterization and chromosomal localization of a human gene related to the poliovirus receptor-encoding gene. in Gene 1995 (PubMed)
    Show all 2 references for ABIN2181679

More Proteins for Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1) Interaction Partners

Mouse (Murine) Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1) interaction partners

  1. nectin-1 regulates the neuronal activities in the CA3 (show CA3 Proteins) region of the hippocampus.

  2. Novel type of cell adhesion apparatus is mediated by Nectin-1 and Nectin-4 (show PVRL4 Proteins). It's implicated in prolactin receptor (show PRLR Proteins) signaling for mammary gland development.

  3. These results indicate that the nectin-1 spots regulate the branching of mitral cell dendrites in the deep sub-lamina of the EPL and suggest that the nectin-1 spots are required for odor information processing in the olfactory bulb.

  4. Results indicate that the nectin-1 spots constitute a novel adhesion apparatus that tethers mitral cell dendrites in a dendritic meshwork structure of the developing mouse olfactory bulb

  5. results demonstrate a role for both nectin-1 and HVEM (show TNFRSF14 Proteins) as receptors and suggest a further receptor which appears much less efficient.

  6. Pvrl1 is a bona fide target gene of the transcription factor p63 (show CKAP4 Proteins), whereas Pvrl4 (show PVRL4 Proteins) regulation is linked to epidermal differentiation and is under Irf6 (show IRF6 Proteins)

  7. In summary, herpes simplex virus 1 entry into epidermis was shown to strongly depend on the presence of nectin-1, but the restricted presence of HVEM (show TNFRSF14 Proteins) can potentially replace nectin-1 as a receptor.

  8. This study demonstrated that nectin1- and nectin3 (show PVRL3 Proteins)-mediated interactions between Cajal-Retzius cells cells and migrating neurons are critical for radial migration

  9. PRR1 nectin-1 plays a role in the formation of intimal thickening after carotid artery ligation.

  10. Nectin-1-specific entry of herpes simplex virus 1 is sufficient for infection of the cornea and viral spread to the trigeminal ganglia.

Human Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1) interaction partners

  1. mutations in exons 2 and 5 of PVRL1, and T334A, A391T, G1183A in the alpha-spliced transcript, and G1082T in the beta-spliced transcript do not participate in the development of non-syndromic cleft of the lip and/or palate in patients from Guangdong.

  2. data suggests that E-cadherin regulates assembly of nectin junctions through alpha-catenin-induced remodeling of the actin cytoskeleton around the cadherin clusters.

  3. The results showed that the interface between the BV gD and nectin-1 molecule is not geometrically complementary.

  4. These data provided solid structural and functional evidence that herpes simplex virus 1 and herpes simplex virus 2 gD proteins recognize nectin-1 via the same binding mode.

  5. Authors show that the same key residues in the BC and FG loops of nectin-4 (show PVRL4 Proteins) govern binding to the measles virus attachment protein hemagglutinin (show HA Proteins) (H) and cell entry, nectin-4 (show PVRL4 Proteins) homodimerization, and heterodimerization with nectin-1.

  6. Host nectin-1 is required for efficient Chlamydia trachomatis serovar E development.

  7. These results suggest that HVEM (show TNFRSF14 Proteins) might play more important roles than CD28 (show CD28 Proteins) in ConA-mediated T cell proliferation

  8. We identified new supportive evidence that the association between PVRL1 gene and nsCL (show NHLH1 Proteins)/P in Turkish patients.

  9. Glycoprotein D (show DARC Proteins) (gD) epitope core structure maps to the external surface of herpesvirus (HSV) gD, corresponding to the binding sites of two receptors, herpesvirus entry mediator (HVEM (show TNFRSF14 Proteins)) and nectin-1, which mediate HSV infection.

  10. The conformation of the N-terminus of herpes simplex virus gD is induced by direct binding to HVEM (show TNFRSF14 Proteins) and nectin-1.

Pig (Porcine) Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1) interaction partners

  1. Contribution of the second and third Ig-like domains of nectin-1 was analysed by generating transgenic mice expressing the entire ectodomain of nectin-1 fused to the porcine Fc portion.

  2. Results demonstrate that a soluble form of the first domain of porcine nectin-1 is able to exert a significant antiviral effect against pseudorabies virus infection.

Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1) Protein Profile

Protein Summary

This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.

Gene names and symbols associated with PVRL1

  • poliovirus receptor-related 1 (herpesvirus entry mediator C) (PVRL1)
  • poliovirus receptor-related 1 (herpesvirus entry mediator C) (Pvrl1)
  • poliovirus receptor-related protein 1-like (LOC100857875)
  • poliovirus receptor-related 2 (herpesvirus entry mediator B) (pvrl2)
  • poliovirus receptor-related protein 1 (pvrl1)
  • Poliovirus receptor-related protein 1 (pvrl1)
  • poliovirus receptor-related 1 (herpesvirus entry mediator C) (pvrl1)
  • poliovirus receptor-related 1 (LOC100341399)
  • poliovirus receptor-related 1 (Pvrl1)
  • AI835281 protein
  • AW549174 protein
  • CD111 protein
  • cd112 protein
  • CLPED1 protein
  • ED4 protein
  • HIgR protein
  • hveb protein
  • HveC protein
  • nectin-1 protein
  • nectin-2 protein
  • OFC7 protein
  • PRR protein
  • PRR1 protein
  • prr2 protein
  • PVRL1 protein
  • PVRR protein
  • PVRR1 protein
  • pvrr2 protein
  • SK-12 protein

Protein level used designations for PVRL1

poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin) , herpesvirus entry mediator C , nectin , poliovirus receptor related protein , poliovirus receptor-related protein 1 , nectin 2 , poliovirus receptor-related 1 (herpesvirus entry mediator C) , Poliovirus receptor-related protein 1 , poliovirus receptor-related 1 , herpes virus entry mediator C , nectin-1 alpha , nectin-1 delta , nectin) , poliovirus receptor-related 1 (herpesvirus entry mediator C , ectodermal dysplasia 4 (Margarita Island type) , herpesvirus Ig-like receptor , nectin 1 , poliovirus receptor-like 1 , nectin-1

GENE ID SPECIES
489363 Canis lupus familiaris
533492 Bos taurus
100724766 Cavia porcellus
100857875 Gallus gallus
448156 Xenopus (Silurana) tropicalis
710072 Macaca mulatta
100074768 Ornithorhynchus anatinus
100145553 Xenopus (Silurana) tropicalis
100286721 Salmo salar
100564991 Anolis carolinensis
100341399 Oryctolagus cuniculus
58235 Mus musculus
192183 Rattus norvegicus
5818 Homo sapiens
397247 Sus scrofa
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