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Poliovirus Receptor-Related 4 Proteins (PVRL4)

PVRL4 encodes a member of the nectin family. Additionally we are shipping PVRL4 Antibodies (58) and PVRL4 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PVRL4 71740 Q8R007
Rat PVRL4 PVRL4 498281  
PVRL4 81607 Q96NY8
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Top PVRL4 Proteins at antibodies-online.com

Showing 9 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,839.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,852.67
Details
HOST_Human Human His tag   10 μg Log in to see 5 Days
$137.50
Details

PVRL4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Human , , , ,
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More Proteins for Poliovirus Receptor-Related 4 (PVRL4) Interaction Partners

Mouse (Murine) Poliovirus Receptor-Related 4 (PVRL4) interaction partners

  1. Novel type of cell adhesion apparatus is mediated by Nectin-1 (show PVRL1 Proteins) and Nectin-4. It's implicated in prolactin receptor (show PRLR Proteins) signaling for mammary gland development.

  2. Pvrl1 (show PVRL1 Proteins) is a bona fide target gene of the transcription factor p63 (show CKAP4 Proteins), whereas Pvrl4 regulation is linked to epidermal differentiation and is under Irf6 (show IRF6 Proteins)

  3. Mouse PVRL4 functions less efficiently as a receptor for measles virus than the human homologue.

  4. Ectodermal dysplasia-syndactyly syndrome is the second known "nectinopathy" caused by mutations in a nectin (show PVRL1 Proteins) adhesion molecule (show NCAM1 Proteins).

Human Poliovirus Receptor-Related 4 (PVRL4) interaction partners

  1. The data presented in this study suggested that nectin-4 may be a therapeutic target for systemic lupus erythematous through affecting the cell apoptosis

  2. Nectin-4 is critical for gallbladder cancer cell progression via PI3K/AKT pathway activation of Rac1.

  3. Nectin-4 expression, when compared with control group, was higher in endometriotic lesions of patients having ovarian endometriosis and peritoneal endometriosis. This difference was significant in the endometrium of patients having endometriosis.

  4. Transformation of breast cancer cells is dependent on PVRL4.

  5. Nectin-4 is a significant prognostic predictor, and may play a critical role in pancreatic cancer. Nectin-4 may be novel therapeutic target for pancreatic cancer.

  6. In airway epithelial cells, measles virus spread requires the nectin-4/afadin complex and is based on cytoplasm transfer between columnar cells.

  7. The present study described clinical investigation of the EDSS1 identified in a large consanguineous family; DNA sequence analysis revealed a novel homozygous nonsense mutation (181C>T, p.Asp61*) in the PVRL4 gene.

  8. Ovarian tissue expression and serum nectin 4 appear to be potential markers in ovarian cancer.

  9. Authors show that the same key residues in the BC and FG loops of nectin-4 govern binding to the measles virus attachment protein hemagglutinin (show HA Proteins) (H) and cell entry, nectin-4 homodimerization, and heterodimerization with nectin-1 (show PVRL1 Proteins).

  10. data outline a synergistic action of nectin-1 and -4 in the early steps of AJ formation and implicate this interaction in modulating the Rac1 signaling pathway

PVRL4 Protein Profile

Protein Summary

This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.

Gene names and symbols associated with PVRL4

  • poliovirus receptor-related 4 (PVRL4)
  • poliovirus receptor-related 4 (pvrl4)
  • poliovirus receptor-related 4 (LOC100348580)
  • poliovirus receptor-related 4 (Pvrl4)
  • 1200017F15Rik protein
  • EDSS1 protein
  • LNIR protein
  • nectin-4 protein
  • PRR4 protein
  • PVRL4 protein
  • RGD1559826 protein
  • si:ch211-155e24.1 protein

Protein level used designations for PVRL4

poliovirus receptor-related 4 , poliovirus receptor-related protein 4-like , ig superfamily receptor LNIR , nectin 4 , nectin-4 , poliovirus receptor-related protein 4 , Ig superfamily receptor LNIR

GENE ID SPECIES
609931 Canis lupus familiaris
794920 Danio rerio
100032730 Monodelphis domestica
100066309 Equus caballus
100348580 Oryctolagus cuniculus
100435072 Pongo abelii
71740 Mus musculus
498281 Rattus norvegicus
81607 Homo sapiens
507718 Bos taurus
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