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PVRL4 encodes a member of the nectin family. Additionally we are shipping PVRL4 Antibodies (68) and PVRL4 Kits (4) and many more products for this protein.
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Novel type of cell adhesion apparatus is mediated by Nectin-1 (show PVRL1 Proteins) and Nectin-4. It's implicated in prolactin receptor (show PRLR Proteins) signaling for mammary gland development.
Pvrl1 (show PVRL1 Proteins) is a bona fide target gene of the transcription factor p63 (show CKAP4 Proteins), whereas Pvrl4 regulation is linked to epidermal differentiation and is under Irf6 (show IRF6 Proteins)
Mouse PVRL4 functions less efficiently as a receptor for measles virus than the human homologue.
Ectodermal dysplasia-syndactyly syndrome is the second known "nectinopathy" caused by mutations in a nectin (show PVRL1 Proteins) adhesion molecule (show NCAM1 Proteins).
The data presented in this study suggested that nectin-4 may be a therapeutic target for systemic lupus erythematous through affecting the cell apoptosis
Nectin-4 is critical for gallbladder cancer cell progression via PI3K/AKT pathway activation of Rac1.
Nectin-4 expression, when compared with control group, was higher in endometriotic lesions of patients having ovarian endometriosis and peritoneal endometriosis. This difference was significant in the endometrium of patients having endometriosis.
Transformation of breast cancer cells is dependent on PVRL4.
Nectin-4 is a significant prognostic predictor, and may play a critical role in pancreatic cancer. Nectin-4 may be novel therapeutic target for pancreatic cancer.
In airway epithelial cells, measles virus spread requires the nectin-4/afadin complex and is based on cytoplasm transfer between columnar cells.
The present study described clinical investigation of the EDSS1 identified in a large consanguineous family; DNA sequence analysis revealed a novel homozygous nonsense mutation (181C>T, p.Asp61*) in the PVRL4 gene.
Ovarian tissue expression and serum nectin 4 appear to be potential markers in ovarian cancer.
Authors show that the same key residues in the BC and FG loops of nectin-4 govern binding to the measles virus attachment protein hemagglutinin (show HA Proteins) (H) and cell entry, nectin-4 homodimerization, and heterodimerization with nectin-1 (show PVRL1 Proteins).
data outline a synergistic action of nectin-1 and -4 in the early steps of AJ formation and implicate this interaction in modulating the Rac1 signaling pathway
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.
poliovirus receptor-related 4
, poliovirus receptor-related protein 4-like
, ig superfamily receptor LNIR
, nectin 4
, poliovirus receptor-related protein 4
, Ig superfamily receptor LNIR