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Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. Additionally we are shipping Poly(A) Binding Protein, Cytoplasmic 4 (Inducible Form) Antibodies (52) and and many more products for this protein.
selective depletion of PABPC4 in an erythroblast cell line inhibits terminal erythroid maturation with corresponding alterations in the erythroid gene expression
The PABPC4 rs4660293 SNP is associated with serum lipid levels.
although function of PABPN1 (show PABPN1 ELISA Kits) may be compensated by nuclear translocation of PABP4 and perhaps by increase the cytoplasmic abundance of PABP5 (show PABPC5 ELISA Kits), these were not sufficient to prevent apoptosis of cells. PABPN1 (show PABPN1 ELISA Kits) may have an anti apoptotic role in mammalian cells
PABPC4 is highly expressed in human colorectal cancer.
Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export
RNA binding masks nuclear import signals within the cytoplasmic poly(A) binding protein RNA recognition motifs, thereby ensuring ef fi cient cytoplasmic retention of this protein in normal cells
Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
polyadenylate-binding protein 4
, poly(A) binding protein, cytoplasmic 4 (inducible form)
, activated-platelet protein 1
, inducible poly(A)-binding protein
, poly(A)-binding protein 4
, poly A binding protein, cytoplasmic 4