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This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. Additionally we are shipping PCBP1 Proteins (9) and PCBP1 Kits (4) and many more products for this protein.
Showing 10 out of 107 products:
Human Polyclonal PCBP1 Primary Antibody for ELISA, WB - ABIN562120
Neff, Lee, Wilusz, Tian, Wilusz: Global analysis reveals multiple pathways for unique regulation of mRNA decay in induced pluripotent stem cells. in Genome research 2012
Show all 3 references for ABIN562120
Human Polyclonal PCBP1 Primary Antibody for IHC, WB - ABIN2778971
Shi, Bencze, Stemmler, Philpott: A cytosolic iron chaperone that delivers iron to ferritin. in Science (New York, N.Y.) 2008
Dog (Canine) Polyclonal PCBP1 Primary Antibody for EIA, WB - ABIN569643
Waggoner, Johannes, Liebhaber: Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest. in The Journal of biological chemistry 2009
Cow (Bovine) Polyclonal PCBP1 Primary Antibody for WB - ABIN2778970
Zhong, Radu, Ju, Brown: Novel progerin-interactive partner proteins hnRNP E1, EGF, Mel 18, and UBC9 interact with lamin A/C. in Biochemical and biophysical research communications 2005
We found a C-rich element (CRE) in mu-opioid receptor (MOR (show OPRM1 Antibodies)) 3'-untranslated region (UTR (show UTS2R Antibodies)) to which poly (rC) binding protein 1 (PCBP1) binds, resulting in MOR (show OPRM1 Antibodies) mRNA stabilization. AUF1 (show HNRNPD Antibodies) phosphorylation also led to an increased interaction with PCBP1.
miR (show MLXIP Antibodies)-7977 in extracellular vesicles may be a critical factor that induces failure of normal hematopoiesis via poly(rC) binding protein 1 suppression in myeloid neoplasms.
Poly C binding protein 1 represses autophagy through downregulation of LC3B (show MAP1LC3B Antibodies) to promote tumor cell apoptosis in starvation
Inhibin betaA is translationally regulated by TGFbeta (show TGFB1 Antibodies) via hnRNP E1.
Suggest that PCBP1 might play an important role in preventing the process of epithelial mesenchymal transformation in NSCLC.
PCBP1 mutations are recurrent in Burkitt lymphomas and might contribute, in cooperation with other mutations, to its pathogenesis.
results showed for the first time that expression of PCBP1 was down-regulated in newly diagnosed acute myeloid leukemia (show BCL11A Antibodies) patients
Findings provide mechanistic evidence for HOTAIR overexpression and PCBP1 downregulation in gastric cancer metastasis and their correlation with poor survival.
Our proteomic profiling and subsequent validation indicate that PCBP1 is central to cancer stem cells enrichment and functionality in prostate cancer.
PCBP1 is a central player in the molecular mechanism causing EMT (show ITK Antibodies) in GBC-SD cells after TGF-beta (show TGFB1 Antibodies) treatment; PCBP1 might serve as a useful biomarker for predicting prognosis of gall bladder cancer metastasis
These data reveal that Pcbp1 and Pcbp2 (show PCBP2 Antibodies) are individually essential for mouse embryonic development and have distinct impacts on embryonic viability and that Pcpb2 has a nonredundant in vivo role in hematopoiesis.
PCBP1 may serve as a novel maternal factor (show ZAR1 Antibodies).
Our analysis of PCBP1 and PCBP2 (show PCBP2 Antibodies) expression demonstrates robust expression of these two proteins within the gastric epithelium with high concordance for both proteins in their cell-type specificities and intracellular distributions.
knockdown of PCBP1 led to a reversal effect on the transcriptional inactivation during oocyte growth, which highlights the important role of PCBP1 in maintaining the gobal transcriptional silencing when the growth phase is completed
TGF-beta (show TGFB1 Antibodies) modulates the expression of Dab2 (show DAB2 Antibodies) and ILEI (show FAM3C Antibodies) mRNA required for epithelial-mesenchymal transdifferentiation by inducing phosphorylation of hnRNP E1, resulting in its release from a structural, 33-nucleotide BAT (show BAAT Antibodies) element in the 3'UTR (show UTS2R Antibodies) of Dab2 (show DAB2 Antibodies) and ILEI (show FAM3C Antibodies).
To define the mechanism of STAT3C suppression of transcript. and/or translational activity of NF-kappaB (show NFKB1 Antibodies) we found that a alphaCP-1 interacted with STAT3C. alphaCP-1 is a K-homol. domain-containing RNA-binding prot (show SLC6A7 Antibodies) with specific for C-rich pyrimidine tracts
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.
poly(rC) binding protein 1
, poly(rC)-binding protein 1-like
, heterogeneous nuclear ribonucleoprotein E1
, heterogenous nuclear ribonucleoprotein E1
, heterogenous nuclear ribonucleoprotein X
, nucleic acid-binding protein SUB2.3
, poly(rC)-binding protein 1
, hnRNP-E1 protein
, hnRNP E1