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Poly(ADP-ribosyl)ation is an immediate DNA damage-dependent posttranslational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Additionally we are shipping PARP14 Antibodies (10) and many more products for this protein.
The PARP14-JNK1-PKM2 regulatory axis is an important determinant for the Warburg effect in tumour cells and provides a mechanistic link between apoptosis and metabolism.
PARP14 interacts with the DNA replication machinery component PCNA (show PCNA ELISA Kits) and promotes replication of DNA lesions and common fragile sites.
The present study further suggests that the combined targeted inhibition of STAT1 (show STAT1 ELISA Kits), ARTD8, ARTD9 and/or DTX3L (show DTX3L ELISA Kits) could increase the efficacy of chemotherapy or radiation treatment in prostate and other high-risk tumor types with an increased STAT1 (show STAT1 ELISA Kits) signaling.
PARP14 has a significant role in the development of allergic inflammation, and targeting PARP14, or even PARP (show COL11A2 ELISA Kits) activity in general, might be an effective therapy for allergic diseases including eosinophilic esophagitis.
Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2 (show MAPK9 ELISA Kits)-dependent pro-survival signal in multiple myeloma.
loss of PARP14 protein is a feature of gastric and colorectal cancers with high microsatellite instability and these alterations might contribute to development of cancers with high microsatellite instability by deregulating PARP (show COL11A2 ELISA Kits)-mediated signaling
BAL macro domains repress transcription when tethered to a promoter; BAL2 and BAL3, but not BAL1, exhibit PARP (show COL11A2 ELISA Kits) activity
PARP enzymatic activity is associated with CoaSt6, and this function of CoaSt6 can append ADP-ribose to itself and p100
these studies demonstrate that PARP-14 regulates multiple cytokine responses during inflammatory immunity.
study provides a novel mechanism for the posttranscriptional regulation of TF expression, indicating that this is selectively regulated by PARP-14.
PARP-14 is an important factor for T helper cell differentiation and it binds to specific DNA sequences to mediate its function.
findings show that PARP14 influences the class distribution, affinity repertoire, and recall capacity of Ab responses in mice
PARP-14-deficient animals show reduced lung pathology.
Data suggest that the PARP14-dependent capacity to increase cellular metabolic rates may be an important determinant of lymphoma pathobiology.
in the presence of IL-4 (show IL4 ELISA Kits) the catalytic activity of PARP-14 facilitates Stat6 (show STAT6 ELISA Kits) binding to the promoter, and release of HDACs so as to activate transcription.
Stat6 (show STAT6 ELISA Kits) binds to collaborator of Stat6 (CoaSt6), a protein that lacks conventional coactivator motifs but contains three iterations of a domain found in the variant histone macroH2A (show H2AFY ELISA Kits).
Data show that Parp-14 is more weakly expressed, mainly in the thymus during development and in adulthood.
Poly(ADP-ribosyl)ation is an immediate DNA damage-dependent posttranslational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP14 belongs to the superfamily of enzymes that perform this modification (Ame et al., 2004
ADP-ribosyltransferase diphtheria toxin-like 8
, B-aggressive lymphoma 2
, b aggressive lymphoma protein 2
, collaborator of STAT6
, poly [ADP-ribose] polymerase 14