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anti-Poly A Specific Ribonuclease (PARN) Antibodies

The protein encoded by PARN is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. Additionally we are shipping PARN Proteins (17) and PARN Kits (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PARN 5073 O95453
PARN 360464  
PARN 74108 Q8VDG3
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Top anti-PARN Antibodies at antibodies-online.com

Showing 10 out of 64 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PARN Antibody Titration: 1.25ug/mlELISA Titer: 1:312500Positive Control: SP2/0 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, WB 100 μL Log in to see 14 Days
$175.80
Details
Mouse Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details
Human Rabbit Un-conjugated IP, WB Western Blot: PARN Antibody [NBP2-19696] - Sample (30 ug of whole cell lysate) A: NIH-3T3 B: BCL-1 7. 5% SDS PAGE gel, diluted at 1:2000. 0.1 mL Log in to see 6 to 9 Days
$447.56
Details
Human Mouse Un-conjugated IHC, WB Immunohistochemistry: PARN Antibody (4D12) [NBP2-46321] - Analysis of Adenocarcinoma of Human breast tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Immunohistochemistry: PARN Antibody (4D12) [NBP2-46321] - Analysis of Carcinoma of Human liver tissue.(Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) 0.1 mL Log in to see 6 to 9 Days
$447.56
Details
Human Rabbit Un-conjugated WB Western Blot: PARN Antibody [NBP1-80250] - Lanes: Lane 1 : 7ug HEK293 cytoplasmic lysate 2: 7ug HEK293 nuclei lysate Primary, Antibody Dilution: 1 : 500 Secondary Antibody: Anti-rabbit-HRP Secondary, Antibody Dilution: 1 : 500 Gene name: PARN. Western Blot: PARN Antibody [NBP1-80250] - SP2/0 cell lysate, concentration 1.25ug/ml. 100 μL Log in to see 6 to 9 Days
$408.19
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of PARN staining in U2OS cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody i Immunohistochemical analysis of PARN staining in human esophageal cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated IF, IHC, WB Western blot analysis of extracts of various cell lines, using PARN antibody. Immunohistochemistry of paraffin-embedded human esophageal cancer using PARN antibody at dilution of 1:100 (x40 lens). 100 μL Log in to see 14 Days
$323.13
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: PARN Antibody [NBP1-84302] - Staining of human stomach shows strong nuclear and cytoplasmic positivity in glandular cells. Western Blot: PARN Antibody [NBP1-84302] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells).Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells) 0.1 mL Log in to see 8 to 11 Days
$439.69
Details

PARN Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
,
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, ,
Rat (Rattus)


Mouse (Murine)


Top referenced anti-PARN Antibodies

  1. Cow (Bovine) Polyclonal PARN Primary Antibody for WB - ABIN2780071 : Katayama, Tomaru, Kasukawa, Waki, Nakanishi, Nakamura, Nishida, Yap, Suzuki, Kawai, Suzuki, Carninci, Hayashizaki, Wells, Frith, Ravasi, Pang, Hallinan, Mattick, Hume, Lipovich, Batalov et al.: Antisense transcription in the mammalian transcriptome.... in Science (New York, N.Y.) 2005 (PubMed)

More Antibodies against PARN Interaction Partners

Human Poly A Specific Ribonuclease (PARN) interaction partners

  1. we found a polyadenylation-dependent 3' end maturation pathway for the human telomerase RNA that relies on the nuclear poly(A)-binding protein PABPN1 (show PABPN1 Antibodies) and the poly(A)-specific RNase PARN.

  2. PARN increased telomerase RNA component levels by deadenylating telomerase RNA component, thereby limiting its degradation by EXOSC10 (show EXOSC10 Antibodies).

  3. Large monoallelic mutations of PARN can cause developmental/mental illness. Biallelic PARN mutations cause severe bone marrow failure and central hypomyelination.

  4. results highlight the clinical significance of PARN and NOC (show CCRN4L Antibodies) on the survival in SCC (show CYP11A1 Antibodies) diagnosed patients.

  5. Mutations in the PARN gene cause dyskeratosis congenital.

  6. The results indicate that the cellular level of miR (show MLXIP Antibodies)-122 is determined by the balance between the opposing effects of GLD-2 (show PAPD4 Antibodies) and PARN/CUGBP1 (show CELF1 Antibodies) on the metabolism of its 3'-terminus.

  7. 3 families with dyskeratosis congenita had key domain mutations in PARN shortening telomeres, reducing deadenylation, and downregulating TERC, DKC1 (show DKC1 Antibodies), RTEL1 (show RTEL1 Antibodies), and TERF1 (show TERF1 Antibodies).

  8. PARN and RTEL1 (show RTEL1 Antibodies) mutation carriers had shortened leukocyte telomere lengths.

  9. poly(A)-specific ribonuclease (PARN) was upregulated in gastric tumor tissues and gastric cancer cell lines MKN28 and AGS (show JAG1 Antibodies).

  10. poly(A) polymerase (show PAPOLA Antibodies) Gld2 (show PAPD4 Antibodies), deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd (show NGDN Antibodies)) are components of a dendritic CPEB (show CPEB1 Antibodies)-associated polyadenylation apparatus

Mouse (Murine) Poly A Specific Ribonuclease (PARN) interaction partners

  1. these data indicate that PARN modulates decay of a defined set of mRNAs in mammalian cells and implicate this deadenylase in coordinating control of genes required for cell movement.

  2. poly(A) polymerase (show PAPOLA Antibodies) Gld2 (show PAPD4 Antibodies), deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd (show NGDN Antibodies)) are components of a dendritic CPEB (show CPEB1 Antibodies)-associated polyadenylation apparatus

  3. Solution structures of the cap-binding domain of mouse PARN with and without the m(7)GpppG cap analog reveal a novel cap-binding mode.

  4. A modeled PARN, which shows that the RRM domain from one subunit and the R3H domain from the other subunit enclose the active site.

PARN Antigen Profile

Protein Summary

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PARN

  • poly(A)-specific ribonuclease (parn) antibody
  • poly(A)-specific ribonuclease (PARN) antibody
  • poly(A)-specific ribonuclease (Parn) antibody
  • poly(A)-specific ribonuclease (deadenylation nuclease) (parn) antibody
  • poly(A)-specific ribonuclease (deadenylation nuclease) (Parn) antibody
  • 1200003I18Rik antibody
  • DAN antibody
  • parn-A antibody
  • RGD1565449 antibody
  • xparn antibody
  • zgc:56067 antibody

Protein level used designations for PARN

deadenylating nuclease , deadenylation nuclease , poly(A)-specific ribonuclease (deadenylation nuclease) , poly(A)-specific ribonuclease PARN , polyadenylate-specific ribonuclease

GENE ID SPECIES
394409 Xenopus laevis
5073 Homo sapiens
479839 Canis lupus familiaris
524155 Bos taurus
360464 Rattus norvegicus
100172259 Pongo abelii
791461 Danio rerio
74108 Mus musculus
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