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PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001 [PubMed 11287196]). Additionally we are shipping PCGF1 Antibodies (39) and PCGF1 Kits (4) and many more products for this protein.
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knockdown of PCGF1 results in reduced expression of DPPA4 (show DPPA4 Proteins) and other subunits of the variant PRC1 (show PRC1 Proteins) complex at both mRNA and protein levels. Thus, PCGF1 represents a physical and functional link between Polycomb (show CBX2 Proteins) function and pluripotency
polycomb (show CBX2 Proteins) has a role in stem cell fate and development of cancer (review)
Nspc1 has a positive role in maintaining the pluripotency of P19 (show CDKN2D Proteins) cells by directly regulating Oct4 (show POU5F1 Proteins).
Pcgf1 is an epigenetic regulator of hematopoietic cell differentiation. Simultaneous depletion of Runx1 (show RUNX1 Proteins) and Pcgf1 allows sustained self-renewal while blocking differentiation of lineage marker-negative cells in vitro.
Nspc1 was expressed globally at the early stage.
PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001
polycomb group ring finger 1
, polycomb group RING finger protein 1
, RING finger protein 68
, nervous system Polycomb-1
, nervous system polycomb 1
, RING finger