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Polycomb Group Ring Finger 2 (PCGF2) ELISA Kits

The protein encoded by PCGF2 contains a RING finger motif and is similar to the polycomb group (PcG) gene products. Additionally we are shipping Polycomb Group Ring Finger 2 Antibodies (63) and Polycomb Group Ring Finger 2 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human PCGF2 PCGF2 7703 P35227
Anti-Mouse PCGF2 PCGF2 22658 P23798
Anti-Rat PCGF2 PCGF2 287662  
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More ELISA Kits for Polycomb Group Ring Finger 2 Interaction Partners

Human Polycomb Group Ring Finger 2 (PCGF2) interaction partners

  1. Suggest a novel role of PCGF2 in arsenic trioxide-mediated degradation of PML (show PML ELISA Kits)-RARA (show RARA ELISA Kits) that PCGF2 might act as a negative regulator of UBE2I (show UBE2I ELISA Kits) via direct interaction.

  2. Mel-18 underexpression in luminal breast cancer cells caused ER-alpha (show ESR1 ELISA Kits) downregulation.Its overexpression restored it in triple-negative breast cancer cells. MEL-18 suppressed SUMOylation of the ESR1 (show ESR1 ELISA Kits) transactivators p53 (show TP53 ELISA Kits) and SP1 (show PSG1 ELISA Kits).

  3. It was therefore concluded that the lower Mel-18 expression might contribute to colorectal cancer development/progression.

  4. Mel-18 functions as a tumor suppressor by its novel negative control of the epithelial-mesenchymal transition in breast cancer.

  5. Findings suggest that Mel-18 is a novel negative regulator of breast cancer stem cell (CSC) that inhibits the stem cell population and in vitro and in vivo self-renewal through the inactivation of Wnt (show WNT2 ELISA Kits)-mediated Notch (show NOTCH1 ELISA Kits) signaling.

  6. PCGF2, a PRC1 (show PRC1 ELISA Kits) gene, played a negative role in the granulocytic differentiation of human APL (show FASL ELISA Kits) cells.

  7. these findings provide that Mel-18 is a novel regulator of tumor angiogenesis through regulating HIF-1alpha (show HIF1A ELISA Kits) and its target VEGF (show VEGFA ELISA Kits) expressions mediated by the PTEN/PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) pathway, suggesting a new tumor-suppressive role of Mel-18 in human breast cancer.

  8. Loss of Mel-18 is associated with prostate cancer.

  9. Our analysis showed correlation between BMI1 (show BMI1 ELISA Kits) and PCGF2 gene's expression and survival in children with medulloblastoma.

  10. Bmi-1 (show BMI1 ELISA Kits)/Mel-18 ratio can be potentially used as a tool for stratifying women at risk of developing breast malignancy.

Mouse (Murine) Polycomb Group Ring Finger 2 (PCGF2) interaction partners

  1. Data indicate that Bmi1 (show BMI1 ELISA Kits) and Mel18 have opposing functions and are present in distinct complexes.

  2. Mel-18 controls the enrichment of tumor-initiating cells in side population fraction in mouse mammary gland cancer.

  3. Data show that Mel-18 and Ezh2 (show EZH2 ELISA Kits) positively regulate the expression of Il17a (show IL17A ELISA Kits) and Il17f (show IL17F ELISA Kits).

  4. Chemokine (show CCL1 ELISA Kits)-mediated thymopoiesis is regulated by a mammalian Polycomb (show CBX2 ELISA Kits) group gene, mel-18

  5. the stoichiometry and/or equilibrium of subunits of the class II Polycomb complex containing Mel-18 might be regulated by changes in phosphorylation status via the PKC signaling pathway

  6. Results provide genetic evidence that Cited2 controls the expression of INK4a/ARF and fibroblast proliferation, at least in part via the polycomb-group genes Bmi1 and Mel18.

  7. Loss or knockdown of mel-18 leads to the expression of Hoxb4 (show HOXB4 ELISA Kits), an increase in the proportion of hematopoietic stem cells in G0 phase, and the subsequent promotion of HSC (show FUT1 ELISA Kits) self-renewal.

  8. Mel-18 contributes to the maintenance of the active state of the Hes-1 gene as a cellular memory system, thereby supporting the expansion of early T lymphocyte progenitors.

  9. Sf3b1 (show SF3B1 ELISA Kits)-Zfp144 protein interaction is essential for true Polycomb (show CBX2 ELISA Kits) group proteins mediated repression of Hox (show MSH2 ELISA Kits) genes.

  10. observed that expression of the PcG genes-bmi1 (show BMI1 ELISA Kits) and mel-18-is correlated with self-renewal and differentiation of HSCs. Thus, it was suggested that the balance between Bmi1 (show BMI1 ELISA Kits) and Mel-18 regulates self-renewal of HSCs

Polycomb Group Ring Finger 2 (PCGF2) Antigen Profile

Antigen Summary

The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.

Gene names and symbols associated with PCGF2

  • polycomb group ring finger 2 (PCGF2) antibody
  • polycomb group ring finger 2 (Pcgf2) antibody
  • mel-18 antibody
  • Mel18 antibody
  • PCGF2 antibody
  • Rnf110 antibody
  • Zfp144 antibody
  • ZNF144 antibody

Protein level used designations for PCGF2

polycomb group RING finger protein 2 , zinc finger protein 144 (Mel-18) (human homolog) , polycomb group ring finger 2 , ring finger protein 110 , DNA-binding protein Mel-18 , zinc finger protein 144 , melanoma nuclear protein 18 , zfp-144

505147 Bos taurus
454614 Pan troglodytes
694187 Macaca mulatta
100017034 Monodelphis domestica
100055282 Equus caballus
7703 Homo sapiens
22658 Mus musculus
287662 Rattus norvegicus
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