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PKD1L1 encodes a member of the polycystin protein family containing 11 transmembrane domains, a receptor for egg jelly (REJ) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. Additionally we are shipping PKD1L1 Antibodies (10) and PKD1L1 Proteins (9) and many more products for this protein.
The authors report that the human PKD2 (show PKD2 ELISA Kits)-L1 selectivity filter is partially selective to calcium ions (Ca(2 (show CA2 ELISA Kits)+)) moving into the cell, but blocked by high internal Ca(2 (show CA2 ELISA Kits)+)concentrations, a unique feature of this transient receptor potential (TRP) channel family member.
identification of bi-allelic PKD1L1 mutations recapitulates previous findings regarding phenotypic consequences of loss of function of the orthologous genes in mice and medaka fish and further expands our understanding of genetic contributions to laterality defects in humans
This paper demonstrates that PKD1L1 can mediate the sensation of fluid flow to elicit Ca2 (show CA2 ELISA Kits)+ signals and implicates a Polycystin domain of PKD1L1 in the response to flow and left-right patterning.
Pkd1l1 is the elusive Pkd2 (show PKD2 ELISA Kits) binding partner required for Left-Right patterning.
Situs inversus and increased embryonic lethality is observed in Pkd1l1-/- mice
This gene encodes a member of the polycystin protein family containing 11 transmembrane domains, a receptor for egg jelly (REJ) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. The encoded protein may play a role in the male reproductive system. Alternative splice variants have been described but their biological nature has not been determined.
polycystic kidney disease 1 like 1
, polycystic kidney disease protein 1-like 1-like
, PC1-like 1 protein
, polycystic kidney disease protein 1-like 1