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PKD2 encodes a member of the polycystin protein family. Additionally we are shipping PKD2 Proteins (14) and PKD2 Kits (8) and many more products for this protein.
Showing 10 out of 92 products:
Human Polyclonal PKD2 Primary Antibody for EIA, WB - ABIN954155
Duning, Rosenbusch, Schlüter, Tian, Kunzelmann, Meyer, Schulze, Markoff, Pavenstädt, Weide: Polycystin-2 activity is controlled by transcriptional coactivator with PDZ binding motif and PALS1-associated tight junction protein. in The Journal of biological chemistry 2010
Show all 5 references for ABIN954155
Human Polyclonal PKD2 Primary Antibody for ELISA, WB - ABIN4346790
Fencl, Janda, Bláhová, Hríbal, Stekrová, Puchmajerová, Seeman: Genotype-phenotype correlation in children with autosomal dominant polycystic kidney disease. in Pediatric nephrology (Berlin, Germany) 2009
Our studies demonstrate that PKD1 (show PKD1 Antibodies)/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha (show DGKA Antibodies) effect on MVB secretory traffic.
Pkd2(-/-) mice with homozygous PKD2(tg)-transgene alleles (Pkd2(-/-);PKD2(tg/tg)) showed significant further amelioration of the cystic severity compared to that in Pkd2(-/-) mice
Results reveal that whereas protein kinase D1 (show PRKD1 Antibodies) and protein kinase D2 are essential for neuronal polarity, there exists a functional redundancy between the two proteins.
Pkd1 (show PKD1 Antibodies) and Pkd2 have coordinate effects on osteoblast differentiation and opposite effects on adipogenesis, suggesting that Pkd1 (show PKD1 Antibodies) and Pkd2 signaling pathways can have independent effects on mesenchymal lineage commitment in bone
novel protein complex composed of Rabep1 (show RABEP1 Antibodies), GGA1 (show GGA1 Antibodies) and Arl3 is responsible for the sorting and targeting of the polycystin 1 (show PKD1 Antibodies) andpolycystin 2 to the cilium.
PKD2 regulates directly and indirectly about 5% of the cytotoxic T-cell phosphoproteome.
The results of this study demonstrate that PC1 (show PCSK1 Antibodies) trafficking and expression require GPS (show NBEAL2 Antibodies) cleavage and PC2 (show CBX4 Antibodies) interaction, respectively, and provide a framework for functional assays to categorize the effects of missense mutations in polycystins.
PKD2 acted as an amplification checkpoint for antigen-stimulated digital cytokine responses and translated the differential strength of TCR signaling to determine the number of naive CD8 (show CD8A Antibodies)(+) T cells that became effector cells.
In inner medullary collecting duct, flow, via polycystin-2 and P2 receptors, engages Ca(2 (show CA2 Antibodies)+)-dependent signaling pathways that stimulate ET-1 (show EDN1 Antibodies) synthesis.
Pkd2(+/-) cardiomyocytes shift the beta adrenergic receptor pathway and have altered calcium handling, independent of desensitized calcium-contraction coupling.
Novel PKD2 mutations in Chinese autosomal dominant polycystic kidney disease patients
Two neutral missense PKD2 variants indentified in exon1 c.83G>C (p.R28P) and c.568G>A (p.A190T), which the former segregate with the mutation in affected relatives, and two new intronic and 3'UTR (show UTS2R Antibodies) variants, c.1548+63C>T and c.*363delA.
this study presents the cryo-EM structure of PKD2 in lipid bilayers at 3.0 A resolution, which establishes PKD2 as a homotetrameric ion channel and provides insight into potential mechanisms for its activation.
PCs expression and p53 (show TP53 Antibodies) activation as a regulator of cell proliferation were further evaluated in vivo and in 69 advanced human carotid atherosclerotic plaques.
PKD2 and RSK1 (show RPS6KA1 Antibodies) regulate integrin beta4 phosphorylation at threonine 1736 to stabilize keratinocyte cell adhesion and its hemidesmosomes.
The coiled-coil domain in the PC2 (show KRT6B Antibodies) C-terminal forms a stable helix bundle regardless of the presence of Ca(2 (show CA2 Antibodies)+).
Results show that some of the previously reported missense or synonymous mutations in PKD2 gene caused altered pre-mRNA splicing.
PKD2 is a core factor in the formation of this multiprotein complex at the TGN (show TG Antibodies) that controls constitutive secretion of matrix metalloproteinase (show MMP20 Antibodies) cargo.
Human polycystin-2 transgene dose-dependently rescues autosomal-dominant polycystic kidney disease phenotypes in Pkd2 mutant mice
FLNA (show FLNA Antibodies) anchors PC2 (show KRT6B Antibodies) to the actin cytoskeleton through complex PC2 (show KRT6B Antibodies)-FLNA (show FLNA Antibodies)-actin to reduce degradation and increase stability, and possibly regulate PC2 (show KRT6B Antibodies) function in a Ca-dependent manner.
These data reveal that the STAM (show STAM Antibodies)-Hrs complex, which down-regulates ligand-activated growth factor receptors from the cell surface of yeast and mammalian cells, also regulates the localization and signaling of a ciliary PC1 (show PCSK1 Antibodies) receptor-TRPP2 complex.
Results demonstrate that somatodendritic and ciliary targeting of PKD-2 requires the transmembrane region of PKD-2 and that the PKD-2 cytosolic termini regulate subcellular distribution and function.
11 mutants found with defects in the ciliary localization (cil) of C. elegans PKD-2, a transient receptor potential polycystin (TRPP) channel
This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2.
polycystic kidney disease 2 protein homolog
, polycystin 2
, autosomal dominant polycystic kidney disease type II protein
, transient receptor potential cation channel, subfamily P, member 2
, polycystic kidney disease 2 homolog
, polycystic kidney disease 2 membrane protein
, serine/threonine-protein kinase D2