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Polyglutamine Binding Protein 1 (PQBP1) ELISA Kits

PQBP1 encodes a nuclear polyglutamine-binding protein that is involved with transcription activation. Additionally we are shipping PQBP1 Antibodies (39) and PQBP1 Proteins (15) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human PQBP1 PQBP1 10084 O60828
PQBP1 54633 Q91VJ5
PQBP1 302557 Q6PCT5
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More ELISA Kits for PQBP1 Interaction Partners

Human Polyglutamine Binding Protein 1 (PQBP1) interaction partners

  1. Study found that PQBP1 directly binds to reverse-transcribed HIV-1 DNA and interacts with cGAS to initiate an IRF3 (show IRF3 ELISA Kits)-dependent innate response.

  2. Mutations in the PQBP1 gene prevent its interaction with the spliceosomal protein (show SF3B4 ELISA Kits) U5-15 kD.

  3. These data demonstrate a role for PQBP1 in the modulation of stress granules.

  4. Data show that the PQBP1 mutation was found in 3 brothers with a phenotype comprising MR, short stature, lean body and microcephaly.

  5. Evidence for a functional involvement of the four mutations affecting ATRX (show ATRX ELISA Kits) (p.1761M4T), PQBP1 (p.155R4X), and SLC6A8 (show SLC6A8 ELISA Kits) (p.390P4L and p.477S4L), in the etiology of intellectual disability.

  6. Whole gene duplication of the PQBP1 gene in syndrome resembling Renpenning.

  7. mutations in PQBP1 caused variable loss of cell adhesion from impaired vesicle trafficking disrupts the neuroepithelial lining or neuronal migration and underlies periventricular heterotopia formation

  8. frameshift mutations in the PQBP-1 gene lead to expression of mutants lacking the ability to interact with U5-15kD

  9. Y65C missense mutation in the WW domain (show DRP2 ELISA Kits) of the Golabi-Ito-Hall syndrome protein PQBP1 affects its binding activity and deregulates pre-mRNA splicing

  10. An evaluation of X-linked mental retardation (XLMR (show DLG3 ELISA Kits)) pathology of PQBP1 mutations demonstrated nonsense-mediated mRNA decay and enhance exclusion of the mutant exon.

Mouse (Murine) Polyglutamine Binding Protein 1 (PQBP1) interaction partners

  1. This study demonstrated that in utero gene therapy for Pqbp1-cKO mice by intraperitoneal injection of the PQBP1-AAV vector at E10 successfully rescued microcephaly with preserved cortical structures and improved behavioral abnormalities in Pqbp1-cKO mice.

  2. These findings define PQBP1 and Dynamin 2 (show DNM2 ELISA Kits) as components of a signaling pathway that orchestrates neuronal ciliary morphogenesis in the brain.

  3. The results indicated that Sox2 (show SOX2 ELISA Kits) regulated the transcription of PQBP1 in neural stem progenitor cells.

  4. PQBP1 can affect the alternative splicing of multiple mRNAs and indicate specific affected targets whose splice site determination may contribute to the disease phenotype in PQBP1-linked neurological disorders

  5. PQBP1 dysfunction in regulating gene expression underlies the abnormal behavior and cognition of PQBP1-Knock-down mice.

  6. PQBP-1 might be involved in neuronal proliferation and/or maturation

PQBP1 Antigen Profile

Antigen Summary

This gene encodes a nuclear polyglutamine-binding protein that is involved with transcription activation. The encoded protein contains a WW domain. Mutations in this gene have been found in patients with Renpenning syndrome 1 and other syndromes with X-linked mental retardation. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Gene names and symbols associated with PQBP1

  • polyglutamine binding protein 1 (PQBP1) antibody
  • polyglutamine binding protein 1 (LOC100345368) antibody
  • polyglutamine binding protein 1 (Pqbp1) antibody
  • MRX55 antibody
  • MRXS3 antibody
  • MRXS8 antibody
  • npw38 antibody
  • PQBP-1 antibody
  • PQBP1 antibody
  • RENS1 antibody
  • Sfc2 antibody
  • SHS antibody

Protein level used designations for PQBP1

polyglutamine binding protein 1 , 38 kDa nuclear protein containing a WW domain , nuclear protein containing WW domain 38 kD , polyglutamine tract-binding protein 1 , polyglutamine-binding protein 1 , PQBP-1 , scurfy candidate 2

739437 Pan troglodytes
100345368 Oryctolagus cuniculus
10084 Homo sapiens
480909 Canis lupus familiaris
534894 Bos taurus
54633 Mus musculus
302557 Rattus norvegicus
100620849 Sus scrofa
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