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PHC1 is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. Additionally we are shipping PHC1 Antibodies (62) and and many more products for this protein.
These findings reveal several cellular defects in cells carrying the PHC1 mutation and highlight the role of chromatin remodeling in the pathogenesis of PM.
PcG complex 1, involving Rae28 and Cdt1 (show CDT1 ELISA Kits), supports the activity of hematopoietic stem cells by enhancing cycling capability and hematopoietic activity through direct regulation of Geminin (show GMNN ELISA Kits)
rae28 has a crucial role in sustaining the activity of hematopoietic stem cells to maintain hematopoiesis
Gene rae28 is involved in cardiac morphogenesis (show XIRP1 ELISA Kits) through a non cardiomyocyte pathway. However, cardiomyocyte-specific overexpression of rae28 caused dilated cardiomyopathy.
The Polycomb (show CBX2 ELISA Kits)-group gene Rae28 sustains Nkx2.5/Csx (show NKX2-5 ELISA Kits) expression and is essential for cardiac morphogenesis (show XIRP1 ELISA Kits).
in vivo results clearly indicate that Polycomb (show CBX2 ELISA Kits)-group gene rae28 is indispensable for the long-term repopulating ability of HSCs
polymeric Scm (show DAB1 ELISA Kits) complexes could extend beyond the local domains of polymeric Ph complexes on chromatin, possibly playing a role in long range repression
functional overlap between Phc2 and Phc1 along with a strict dose-dependent requirement during anterior-posterior (A-P) patterning
This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein.
, polyhomeotic-like protein 1
, early development regulator 1 (homolog of polyhomeotic 1)
, early development regulatory protein 1
, early development regulator1 (homolog of polyhomeotic 1)