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anti-Polymerase (DNA Directed), gamma (POLG) Antibodies

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. Additionally we are shipping POLG Proteins (6) and POLG Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
POLG 5428 P54098
POLG 18975  
POLG 85472 Q9QYV8
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Top anti-POLG Antibodies at antibodies-online.com

Showing 10 out of 53 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, FACS, IF, IHC (p), WB Flow cytometric analysis of CEM cells using POLG Antibody (C-term) Cat.-No AP53379PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Confocal immunofluorescent analysis of POLG Antibody (C-term) Cat.-No AP53379PU-N with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue). 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Immunofluorescence analysis of methanol-fixed HeLa, using DNA polymerase gamma antibody at 1:200 dilution. Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 6 to 8 Days
$500.50
Details
Mouse Rabbit Un-conjugated FACS, IF, IHC (p), WB POLG Antibody (C-term)  western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the POLG antibody detected the POLG protein (arrow). POLG Antibody (C-term)  flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-DNA Polymerase gamma Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining. Formalin-fixed and paraffin embedded human laryngeal tissue labeled with Anti-DNA Polymerase gamma Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL Log in to see 14 to 21 Days
$269.50
Details
Human Rabbit Un-conjugated ICC, IF, IP, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: MCF-7 5% SDS PAGE antibody diluted at 1:1000 IHC-P Image Immunohistochemical analysis of paraffin-embedded human skeletal muscle, using DNA polymerase gamma, antibody(10 μg/ml). 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 8 to 10 Days
$451.00
Details
Mouse Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Mouse Un-conjugated ELISA, WB   50 μg Log in to see 8 to 10 Days
$610.50
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

POLG Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-POLG Antibodies

  1. Human Polyclonal POLG Primary Antibody for EIA, FACS - ABIN954236 : Tong, Sullivan, Lawless, Vanderhoof, Zachman, Nelson: Five mutations of mitochondrial DNA polymerase-gamma (POLG) are not a prevalent etiology for spontaneous 46,XX primary ovarian insufficiency. in Fertility and sterility 2010 (PubMed)
    Show all 3 references for ABIN954236

  2. Human Polyclonal POLG Primary Antibody for WB - ABIN2783430 : Mancini, Roncaglia, Brussino, Stevanin, Lo Buono, Krmac, Maltecca, Gazzano, Bartoletti Stella, Calvaruso, Iommarini, Cagnoli, Forlani, Le Ber, Durr, Brice, Ghigo, Casari, Porcelli, Funaro, Gasparre et al.: Genome-wide expression profiling and functional characterization of SCA28 lymphoblastoid cell lines reveal impairment in cell growth and activation of apoptotic pathways. ... in BMC medical genomics 2013 (PubMed)

More Antibodies against POLG Interaction Partners

Fruit Fly (Drosophila melanogaster) Polymerase (DNA Directed), gamma (POLG) interaction partners

  1. The stimulatory effect of mtSSB (show SSBP1 Antibodies) on Pol gamma on these ssDNA templates is not species-specific.

  2. Muscle-specific (show EIF3K Antibodies) overexpression of the catalytic subunit of DNA polymerase gamma induces pupal lethality in Drosophila melanogaster.

  3. mtSSB (show SSBP1 Antibodies) uses distinct structural elements to interact functionally with its mtDNA replisome partners and to promote proper mtDNA replication in animal cells

  4. DNA-binding mutants of mitochondrial single-stranded DNA-binding protein (show RPA1 Antibodies) are defective in stimulation of DNA synthesis by pol gamma

Human Polymerase (DNA Directed), gamma (POLG) interaction partners

  1. CAG repeat (show CELF3 Antibodies) polymorphism in the mitochondrial DNA polymerase gamma gene (POLG) does not appear to be associated with colorectal cancer

  2. altered genetic and epigenetic regulation of POLG1 in human cancers and suggest a role for POLG1 germline variants in promoting tumorigenic properties.

  3. Herein we report a patient with a POLG gene W748S homozygous mutation and characteristic lesions in the thalamus, cerebellum and inferior olivary nucleus seen on magnetic resonance imaging.

  4. POLG's 3'-5' exonuclease (show EXOSC10 Antibodies) proofreading activity is required for the creation of ligatable ends during mtDNA replication.

  5. The stimulatory effect of mtSSB (show SSBP1 Antibodies) on Pol gamma on these ssDNA templates is not species-specific.

  6. Computational analysis of the PolG protein suggests that the p.K601E mutation is likely the most significant contributing factor to a pathogenic phenotype in an adult mitochondrial ataxia (show USP14 Antibodies).

  7. Data suggest that methylation of mitochondrial DNA in exon 2 of POLGA is instrumental in regulation of DNA replication in pluripotent stem cells, in embryonic development, and in tumorigenesis. [REVIEW]

  8. Family case study and literature review of the complexity of genotype-phenotype correlations of POLG1 gene

  9. Multiple deletions of mitochondrial DNA were detected along with a novel mutation in POLG1 in patients with Parkinsonism, cognitive deficit and behavioral disturbance.

  10. The results of this study provided evidence for a significantly lower of mtDNA copy number in PD patients and POLG1 variation for reducing mtDNA copy number in Parkinson dseases.

Mouse (Murine) Polymerase (DNA Directed), gamma (POLG) interaction partners

  1. Taken together, our findings may provide clues to further investigate the molecular mechanism underlying premature aging phenotype in Polg mutant mice.

  2. POLG's 3'-5' exonuclease (show EXOSC10 Antibodies) proofreading activity is required for the creation of ligatable ends during mtDNA replication.

  3. PolG mice display an enhanced reliance on glycolysis as compared to their wild-type counterparts.

  4. mitochondrial respiratory chain proteins are specifically decreased in abundance in the brains of the polg mutator mice, including several nuclear encoded mitochondrial components.

  5. in a mouse odel of diabetic retinopathy, POLG1 continued to be down-regulated, the D-loop region damaged, and the CpG islands at the regulatory region of POLG hyper-methylated even after three months of glycemic control

  6. This method gives us insights into the pausing of two pol-gamma variants: the A467T substitution that causes PEO (show C10ORF2 Antibodies) and Alpers syndrome, and the exonuclease (show EXO1 Antibodies) deficient pol-gamma (exo (show XRN1 Antibodies)(-)) in premature aging mouse models.

  7. reduced diabetic symptoms of aging Polg (D257A mutation in mitochondrial DNA polymerase gamma) Akita males results from appetite suppression triggered by decreased testosterone associated with damage to the Leydig cells of the testis

  8. Control region multimers demonstrate that polymerase-gamma 3'-5' exonuclease (show EXOSC10 Antibodies) activity is required for preserving mtDNA integrity.

  9. causative link between mtDNA mutations and ageing phenotypes, seen in Polg mutant knock-in mice

  10. Dnaja3 (show DNAJA3 Antibodies) is crucial for mitochondrial biogenesis through its chaperone activity on Polga and has a role in preventing dilated cardiomyopathy

POLG Antigen Profile

Protein Summary

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with POLG

  • tamas (tam) antibody
  • polymerase (DNA directed), gamma (POLG) antibody
  • DNA polymerase gamma 35kD (DNApol-gamma35) antibody
  • polymerase (DNA directed), gamma (polg) antibody
  • polymerase (DNA directed), gamma (Polg) antibody
  • 34Dc antibody
  • AA409516 antibody
  • AAC47658 antibody
  • anon-34Dc antibody
  • BG:DS00941.6 antibody
  • BG:DS00941.9 antibody
  • br5 antibody
  • br16 antibody
  • cDNA 2 antibody
  • CG8969 antibody
  • CG8987 antibody
  • CG33084 antibody
  • CG33650 antibody
  • D-pol gamma-alpha antibody
  • D-pol gamma-beta antibody
  • Dmel\\CG8987 antibody
  • Dmel\\CG33650 antibody
  • DNA pol-gam.35 antibody
  • DNApol-gamma antibody
  • DNApol-gamma.35 antibody
  • DNApol-gamma125 antibody
  • l(2)34Dc antibody
  • l(2)34De antibody
  • l(2)br5 antibody
  • l(2)br14 antibody
  • l(2)br16 antibody
  • l(2)brS antibody
  • MDP1 antibody
  • MIRAS antibody
  • mtDNA pol antibody
  • MTDPS4A antibody
  • MTDPS4B antibody
  • mtPolA antibody
  • MtPolB antibody
  • PEO antibody
  • PolG antibody
  • POLG1 antibody
  • PolgA antibody
  • polgamma antibody
  • pol gamma antibody
  • pol gamma-alpha antibody
  • polgamma-alpha antibody
  • polgamma-beta antibody
  • pol gamma-beta antibody
  • pol gamma35 antibody
  • SANDO antibody
  • SCAE antibody
  • Tam antibody

Protein level used designations for POLG

CG8987-PA , DNA polymerase gamma , DNA polymerase gamma 125kD , alpha subunit , catalytic subunit of the mitochondrial DNA polymerase , catalytic(alpha)subunit , lethal 14 in the black-reduced region , lethal 5 in the black-reduced region , lethal(2)34Dc , mitochondrial gamma polymerase , mtDNA polymerase alpha , tam-PA , polymerase (DNA directed), gamma , CG33650-PA , DNA polymerase -gamma , DNApol-gamma35-PA , accessory subunit of mitochondrial DNA polymerase , accessory(beta)subunit , beta subunit , lethal 16 in the black-reduced region , lethal(2)34De , mitochondrial DNA polymerase accessory subunit , DNA polymerase subunit gamma-1-like , DNA polymerase subunit gamma-1 , PolG-alpha , mitochondrial DNA polymerase catalytic subunit , DNA polymerase gamma subunit 1 (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha) , Pol gamma , mitochondrial DNA polymerase gamma , mitochondrial DNA polymerase-gamma , mitochondrial polymerase gamma , polG-alpha , polymerase, gamma , DNA-directed DNA polymerase gamma

GENE ID SPECIES
34792 Drosophila melanogaster
467754 Pan troglodytes
488732 Canis lupus familiaris
699750 Macaca mulatta
3772064 Drosophila melanogaster
100038061 Xenopus (Silurana) tropicalis
100053827 Equus caballus
100408039 Callithrix jacchus
5428 Homo sapiens
18975 Mus musculus
85472 Rattus norvegicus
404292 Gallus gallus
397851 Xenopus laevis
Selected quality suppliers for anti-POLG (POLG) Antibodies
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