anti-Polymerase (DNA Directed), gamma (POLG) Antibodies

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. Additionally we are shipping POLG Proteins (32) and POLG Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
POLG 5428 P54098
POLG 18975  
POLG 85472 Q9QYV8
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Top anti-POLG Antibodies at antibodies-online.com

Showing 10 out of 56 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB Western Blot: DNA Polymerase gamma Antibody [NBP1-52300] - Analysis of anti-POLG antibody with (30 ug of whole cell lysate). A: 293T. 5% SDS PAGE. POLG antibody diluted at 1:5000. Immunocytochemistry/Immunofluorescence: DNA Polymerase gamma Antibody [NBP1-52300] - Analysis of anti-POLG antibody with methanol-fixed HeLa cell at 1:200 dilution. 0.05 mL Log in to see 10 to 13 Days
$447.56
Details
Human Rabbit Un-conjugated EIA, FACS, IF, IHC (p), WB   0.4 mL Log in to see 12 to 15 Days
$375.38
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-DNA Polymerase gamma Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining. Formalin-fixed and paraffin embedded human laryngeal tissue labeled with Anti-DNA Polymerase gamma Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL Log in to see 14 to 21 Days
$295.90
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Immunofluorescence analysis of methanol-fixed HeLa, using DNA polymerase gamma antibody at 1:200 dilution. Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 6 to 8 Days
$500.50
Details
Mouse Rabbit Un-conjugated FACS, IF, IHC (p), WB POLG Antibody (C-term)  western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the POLG antibody detected the POLG protein (arrow). POLG Antibody (C-term)  flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: DNA Polymerase gamma Antibody [NBP1-33633] - Paraffin-embedded Skeletal Muscle, using antibody 10 ug/ml. Western Blot: DNA Polymerase gamma Antibody [NBP1-33633] - Sample (30 ug of whole cell lysate) A: MCF-7 5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Log in to see 7 to 9 Days
$447.56
Details
Human Rabbit Un-conjugated ICC, IF, IP, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: MCF-7 5% SDS PAGE antibody diluted at 1:1000 IHC-P Image Immunohistochemical analysis of paraffin-embedded human skeletal muscle, using DNA polymerase gamma, antibody(10 μg/ml). 100 μL Log in to see 1 to 2 Days
$358.60
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details

POLG Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-POLG Antibodies

  1. Human Polyclonal POLG Primary Antibody for ICC, IF - ABIN4305533 : Wu, Li, Zhang, Wu, Huang, Chen: Mitochondrial DNA base excision repair and mitochondrial DNA mutation in human hepatic HuH-7 cells exposed to stavudine. in Mutation research 2009 (PubMed)
    Show all 3 references for 4305533

  2. Cow (Bovine) Polyclonal POLG Primary Antibody for WB - ABIN2783430 : Mancini, Roncaglia, Brussino, Stevanin, Lo Buono, Krmac, Maltecca, Gazzano, Bartoletti Stella, Calvaruso, Iommarini, Cagnoli, Forlani, Le Ber, Durr, Brice, Ghigo, Casari, Porcelli, Funaro, Gasparre et al.: Genome-wide expression profiling and functional characterization of SCA28 lymphoblastoid cell lines reveal impairment in cell growth and activation of apoptotic pathways. ... in BMC medical genomics 2013 (PubMed)

  3. Human Polyclonal POLG Primary Antibody for IF (p), IHC (p) - ABIN1714946 : Chen, Zhao, Cai, Sun, Hu, Huang, Kong, Kong: The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways. in Redox biology 2017 (PubMed)

More Antibodies against POLG Interaction Partners

Fruit Fly (Drosophila melanogaster) Polymerase (DNA Directed), gamma (POLG) interaction partners

  1. The stimulatory effect of mtSSB (show SSBP1 Antibodies) on Pol gamma on these ssDNA templates is not species-specific.

  2. Muscle-specific (show EIF3K Antibodies) overexpression of the catalytic subunit of DNA polymerase gamma induces pupal lethality in Drosophila melanogaster.

  3. mtSSB (show SSBP1 Antibodies) uses distinct structural elements to interact functionally with its mtDNA replisome partners and to promote proper mtDNA replication in animal cells

  4. DNA-binding mutants of mitochondrial single-stranded DNA-binding protein (show RPA1 Antibodies) are defective in stimulation of DNA synthesis by pol gamma

Human Polymerase (DNA Directed), gamma (POLG) interaction partners

  1. The rs758130 in POLG gene was significantly associated with the prognosis of patients in a dose-dependent manner. Moreover, GG genotype in rs1061316 showed significantly high mtDNA content, an indicator of better prognosis.

  2. Pol G composes the mtDNA replication machinery, this replication machinery and failure to repair these mtDNA errors results in mtDNA mutations and as a result mitochondrial dysfunction - a major driving force behind aging and age-related diseases.

  3. POLG mutations are associated with progressive external ophthalmoplegia.

  4. tudies on the impact of mitochondrial DNA variants present conflicting data but highlight POLG as a particularly interesting candidate gene for both male and female infertility.

  5. This review presented that the patient with epilepsy due to homozygous pathogenic variants located in the linker region of POLG were associated with later age of onset and longer survival compared to compound heterozygous variants.

  6. MGME1 processes flaps into ligatable nicks in concert with DNA polymerase gamma during mtDNA replication.

  7. Study further demonstrated the broad POLG-related spectrum and led to the identification of Sensory Ataxic Neuropathy with Ophthalmoparesis but without dysarthria (SANO), a new yet common phenotype of this spectrum characterized by the lack of cerebellar signs and by a less severe prognosis than in Sensory Ataxic Neuropathy, Dysarthria and Ophthalmoparesis (SANDO) and Spino (show PPP1R9B PLURAL_@14456@) Cerebellar Ataxia (show USP14 PLURAL_@14456@) with Epilepsy (SCAE)

  8. molecular dynamics simulations of the human Pol gamma replicative complex

  9. Overall, POLG interactome mapping identifies novel proteins which support mitochondrial biogenesis and a potential novel mitochondrial isoform of Ruvbl2 (show RUVBL2 Antibodies).

  10. lymphocytes with POLG mutations are more sensitive than control cells to oxidative stress-induced (show SQSTM1 Antibodies) apoptosis.

Mouse (Murine) Polymerase (DNA Directed), gamma (POLG) interaction partners

  1. Cardiac mitochondrial polymerase gamma dysfunction alters nuclear DNA methylation (show HELLS Antibodies).

  2. Taken together, our findings may provide clues to further investigate the molecular mechanism underlying premature aging phenotype in Polg mutant mice.

  3. POLG's 3'-5' exonuclease (show EXOSC10 Antibodies) proofreading activity is required for the creation of ligatable ends during mtDNA replication.

  4. PolG mice display an enhanced reliance on glycolysis as compared to their wild-type counterparts.

  5. mitochondrial respiratory chain proteins are specifically decreased in abundance in the brains of the polg mutator mice, including several nuclear encoded mitochondrial components.

  6. in a mouse odel of diabetic retinopathy, POLG1 continued to be down-regulated, the D-loop region damaged, and the CpG islands at the regulatory region of POLG hyper-methylated even after three months of glycemic control

  7. This method gives us insights into the pausing of two pol-gamma variants: the A467T substitution that causes PEO (show C10ORF2 Antibodies) and Alpers syndrome, and the exonuclease (show EXO1 Antibodies) deficient pol-gamma (exo (show XRN1 Antibodies)(-)) in premature aging mouse models.

  8. reduced diabetic symptoms of aging Polg (D257A mutation in mitochondrial DNA polymerase gamma) Akita males results from appetite suppression triggered by decreased testosterone associated with damage to the Leydig cells of the testis

  9. Control region multimers demonstrate that polymerase-gamma 3'-5' exonuclease (show EXOSC10 Antibodies) activity is required for preserving mtDNA integrity.

  10. causative link between mtDNA mutations and ageing phenotypes, seen in Polg mutant knock-in mice

POLG Antigen Profile

Protein Summary

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with POLG

  • tamas (tam) antibody
  • polymerase (DNA directed), gamma (POLG) antibody
  • DNA polymerase gamma 35kD (DNApol-gamma35) antibody
  • polymerase (DNA directed), gamma (polg) antibody
  • polymerase (DNA directed), gamma (Polg) antibody
  • 34Dc antibody
  • AA409516 antibody
  • AAC47658 antibody
  • anon-34Dc antibody
  • BG:DS00941.6 antibody
  • BG:DS00941.9 antibody
  • br5 antibody
  • br16 antibody
  • cDNA 2 antibody
  • CG8969 antibody
  • CG8987 antibody
  • CG33084 antibody
  • CG33650 antibody
  • D-pol gamma-alpha antibody
  • D-pol gamma-beta antibody
  • Dmel\\CG8987 antibody
  • Dmel\\CG33650 antibody
  • DNA pol-gam.35 antibody
  • DNApol-gamma antibody
  • DNApol-gamma.35 antibody
  • DNApol-gamma125 antibody
  • l(2)34Dc antibody
  • l(2)34De antibody
  • l(2)br5 antibody
  • l(2)br14 antibody
  • l(2)br16 antibody
  • l(2)brS antibody
  • MDP1 antibody
  • MIRAS antibody
  • mtDNA pol antibody
  • MTDPS4A antibody
  • MTDPS4B antibody
  • mtPolA antibody
  • MtPolB antibody
  • PEO antibody
  • PolG antibody
  • POLG1 antibody
  • PolgA antibody
  • polgamma antibody
  • pol gamma antibody
  • pol gamma-alpha antibody
  • polgamma-alpha antibody
  • polgamma-beta antibody
  • pol gamma-beta antibody
  • pol gamma35 antibody
  • SANDO antibody
  • SCAE antibody
  • Tam antibody

Protein level used designations for POLG

CG8987-PA , DNA polymerase gamma , DNA polymerase gamma 125kD , alpha subunit , catalytic subunit of the mitochondrial DNA polymerase , catalytic(alpha)subunit , lethal 14 in the black-reduced region , lethal 5 in the black-reduced region , lethal(2)34Dc , mitochondrial gamma polymerase , mtDNA polymerase alpha , tam-PA , polymerase (DNA directed), gamma , CG33650-PA , DNA polymerase -gamma , DNApol-gamma35-PA , accessory subunit of mitochondrial DNA polymerase , accessory(beta)subunit , beta subunit , lethal 16 in the black-reduced region , lethal(2)34De , mitochondrial DNA polymerase accessory subunit , DNA polymerase subunit gamma-1-like , DNA polymerase subunit gamma-1 , PolG-alpha , mitochondrial DNA polymerase catalytic subunit , DNA polymerase gamma subunit 1 (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha) , Pol gamma , mitochondrial DNA polymerase gamma , mitochondrial DNA polymerase-gamma , mitochondrial polymerase gamma , polG-alpha , polymerase, gamma , DNA-directed DNA polymerase gamma

GENE ID SPECIES
34792 Drosophila melanogaster
467754 Pan troglodytes
488732 Canis lupus familiaris
699750 Macaca mulatta
3772064 Drosophila melanogaster
100038061 Xenopus (Silurana) tropicalis
100053827 Equus caballus
100408039 Callithrix jacchus
5428 Homo sapiens
18975 Mus musculus
85472 Rattus norvegicus
404292 Gallus gallus
397851 Xenopus laevis
Selected quality suppliers for anti-POLG (POLG) Antibodies
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