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Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Additionally we are shipping POLR1B Proteins (3) and many more products for this protein.
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Increased transcription and protein expression of polymerase I regulon is consistent with the increase in ribosomal RNA following skeletal muscle hypertrophy.
PTEN (show PTEN Antibodies) represses RNA Pol I transcription through a novel mechanism that involves disruption of the SL1 (show MMP3 Antibodies) complex
CK2 has the potential to regulate Pol I transcription at multiple levels, in preinitiation complex (PIC) formation, activation, and reinitiation of transcription.
Human Maf1 protein negatively regulates transcription by all three nuclear Pols. Changes in Maf1 expression affect Pol I-dependent transcription in human glioblastoma lines.
The average FIX expression level of the rDNA recombinants was additionally enhanced to that from a strong Pol II promoter as a result of elimination of position effects.
Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides, depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in yeast. POLR1B is homologous to Rpa2 (Seither and Grummt, 1996
DNA-directed RNA polymerase I subunit RPA2
, polymerase (RNA) I polypeptide B, 128kDa
, RNA polymerase I polypeptide B
, RNA polymerase I subunit 2
, DNA-directed RNA polymerase I subunit RPA2-like
, DNA-directed RNA polymerase I 135 kDa polypeptide
, DNA-directed RNA polymerase I 135kDa polypeptide
, RNA polymerase 1-2, 128 kDa subunit
, RNA polymerase 1-2
, RNA polymerase I (127 kDa subunit)