Polymerase (RNA) III (DNA Directed) Polypeptide A, 155kDa (POLR3A) ELISA Kits

The protein encoded by POLR3A is the catalytic component of RNA polymerase III, which synthesizes small RNAs. Additionally we are shipping Polymerase (RNA) III (DNA Directed) Polypeptide A, 155kDa Antibodies (33) and Polymerase (RNA) III (DNA Directed) Polypeptide A, 155kDa Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse POLR3A POLR3A 218832  
Anti-Rat POLR3A POLR3A 361102  
Anti-Human POLR3A POLR3A 11128 O14802
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More ELISA Kits for Polymerase (RNA) III (DNA Directed) Polypeptide A, 155kDa Interaction Partners

Human Polymerase (RNA) III (DNA Directed) Polypeptide A, 155kDa (POLR3A) interaction partners

  1. Findings suggest that AP-1 factors are regulators of RNA polymerase III (Pol III)-driven 5S rRNA and U6 snRNA expression with a potential role in cell proliferation.

  2. For some of its complex functions, variation in RNAP III activity levels lead to nonuniform changes in tRNA pools that can shift the translation profiles of key codon-biased mRNAs with resultant phenotypes or disease states. (Review)

  3. Mutations in POLR3A are a frequent cause of sporadic and recessive spastic ataxia.

  4. RNA polymerase III (RNAPIII) is specialized for transcription of short, abundant nonprotein-coding RNA transcripts.

  5. Our transcriptome-wide investigations revealed an overall decrease in the levels of Pol III-transcribed tRNAs and an imbalance in the levels of regulatory ncRNAs such as small nuclear and nucleolar RNAs (snRNAs and snoRNAs).

  6. Multicenter retrospective study to collect neuroradiologic, clinical, and molecular data of patients with mutations in POLR3A and POLR3B (show POLR3B ELISA Kits) without the classic MRI (show C7ORF49 ELISA Kits) phenotype: diffuse hypomyelination is not an obligatory feature of POLR3-related disorders; two distinct patterns, selective involvement of the corticospinal tracts and cerebellar atrophy, are added to the MRI (show C7ORF49 ELISA Kits) presentation of POLR3-related disorders

  7. Mutations in POLR3A or POLR3B (show POLR3B ELISA Kits) are rare in patients with unclassified hypomyelination.

  8. Mutations in POLR3A are associated with a more severe clinical course of 4H leukodystrophy.

  9. MRI (show C7ORF49 ELISA Kits) in patients with POLR3B (show POLR3B ELISA Kits) mutations revealed smaller cerebellar structures, especially vermis, than those in POLR3A mutations. MRI (show C7ORF49 ELISA Kits) also showed milder hypomyelination in patients with POLR3B (show POLR3B ELISA Kits) mutations than those with POLR3A mutations

  10. Investigated POLR3A and POLR3B (show POLR3B ELISA Kits) mutations in patients with genetically unexplained hypomyelinating leukodystrophies with features of Pol III-related leukodystrophies. Recessive mutations in POLR3A or POLR3B (show POLR3B ELISA Kits) were uncovered in all 14 patients.

Polymerase (RNA) III (DNA Directed) Polypeptide A, 155kDa (POLR3A) Antigen Profile

Antigen Summary

The protein encoded by this gene is the catalytic component of RNA polymerase III, which synthesizes small RNAs. The encoded protein also acts as a sensor to detect foreign DNA and trigger an innate immune response.

Gene names and symbols associated with POLR3A

  • polymerase (RNA) III (DNA directed) polypeptide A (Polr3a) antibody
  • polymerase (RNA) III (DNA directed) polypeptide A, 155kDa (POLR3A) antibody
  • 9330175N20Rik antibody
  • ADDH antibody
  • BC053071 antibody
  • HLD7 antibody
  • hRPC155 antibody
  • RGD1305574 antibody
  • RPC1 antibody
  • RPC155 antibody

Protein level used designations for POLR3A

DNA-directed RNA polymerase III subunit RPC1 , polymerase (RNA) III (DNA directed) polypeptide A, 155kDa , DNA-directed RNA polymerase III largest subunit , DNA-directed RNA polymerase III subunit A , RNA polymerase III 155 kDa subunit , RNA polymerase III subunit C1 , RNA polymerase III subunit C160 , RNA polymerase III subunit RPC155-D

GENE ID SPECIES
218832 Mus musculus
361102 Rattus norvegicus
11128 Homo sapiens
479256 Canis lupus familiaris
540308 Bos taurus
423727 Gallus gallus
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